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Article: The association of lysophosphatidylcholine with isolated cardiac myocytes

TitleThe association of lysophosphatidylcholine with isolated cardiac myocytes
Authors
Issue Date1990
PublisherA O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htm
Citation
Lipids, 1990, v. 25 n. 8, p. 450-454 How to Cite?
AbstractThe ability of exogenous lysophosphatidylcholine to produce electrophysiological derangements and cardiac arrhythmias in the heart has been documented. The action action of lysophosphatidylcholine is thought to be mediated via its association with the membrane. The present study examined the nature of the association of lysophosphatidylcholine with isolated rat myocyte mebrane. The association was studied by incubating myocytes in a lysophosphatidylcholine-containing medium. The association of lysophosphatidylcholine with the myocyte sarcolemma was not affected by palmitic acid and glycerophosphocholine but was reduced by platelet-activating factor (PAF). The addition of albumin (5 mg/mL) at the end of the incubation period effectively removed the lysophosphatidylcholine from the myocytes. Our results suggest that most of the lysophosphatidylcholine in isolated myocytes was associated preferentially with the outer leaflet of the myocyte sarcolemma. This type of association might be responsible for the lysophosphatidylcholine-induced electrophysiological alterations in the heart.
Persistent Identifierhttp://hdl.handle.net/10722/170967
ISSN
2015 Impact Factor: 1.892
2015 SCImago Journal Rankings: 0.795
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_US
dc.contributor.authorKinnaird, AAAen_US
dc.contributor.authorBihler, Ien_US
dc.contributor.authorChoy, PCen_US
dc.date.accessioned2012-10-30T06:11:38Z-
dc.date.available2012-10-30T06:11:38Z-
dc.date.issued1990en_US
dc.identifier.citationLipids, 1990, v. 25 n. 8, p. 450-454en_US
dc.identifier.issn0024-4201en_US
dc.identifier.urihttp://hdl.handle.net/10722/170967-
dc.description.abstractThe ability of exogenous lysophosphatidylcholine to produce electrophysiological derangements and cardiac arrhythmias in the heart has been documented. The action action of lysophosphatidylcholine is thought to be mediated via its association with the membrane. The present study examined the nature of the association of lysophosphatidylcholine with isolated rat myocyte mebrane. The association was studied by incubating myocytes in a lysophosphatidylcholine-containing medium. The association of lysophosphatidylcholine with the myocyte sarcolemma was not affected by palmitic acid and glycerophosphocholine but was reduced by platelet-activating factor (PAF). The addition of albumin (5 mg/mL) at the end of the incubation period effectively removed the lysophosphatidylcholine from the myocytes. Our results suggest that most of the lysophosphatidylcholine in isolated myocytes was associated preferentially with the outer leaflet of the myocyte sarcolemma. This type of association might be responsible for the lysophosphatidylcholine-induced electrophysiological alterations in the heart.en_US
dc.languageengen_US
dc.publisherA O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htmen_US
dc.relation.ispartofLipidsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Pharmacologyen_US
dc.subject.meshGlycerylphosphorylcholine - Pharmacologyen_US
dc.subject.meshLidocaine - Pharmacologyen_US
dc.subject.meshLysophosphatidylcholines - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshPalmitic Aciden_US
dc.subject.meshPalmitic Acids - Pharmacologyen_US
dc.subject.meshPlatelet Activating Factor - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSarcolemma - Drug Effects - Metabolismen_US
dc.subject.meshTemperatureen_US
dc.titleThe association of lysophosphatidylcholine with isolated cardiac myocytesen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02538087en_US
dc.identifier.pmid2215087-
dc.identifier.scopuseid_2-s2.0-0024992363en_US
dc.identifier.volume25en_US
dc.identifier.issue8en_US
dc.identifier.spage450en_US
dc.identifier.epage454en_US
dc.identifier.isiWOS:A1990DU81500005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridKinnaird, AAA=6603472891en_US
dc.identifier.scopusauthoridBihler, I=7004038092en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US

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