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Article: Effects of the free radical generating system FeCl 3/ADP on reperfusion arrhythmias of rat hearts and electrical activity of canine Purkinje fibres

TitleEffects of the free radical generating system FeCl 3/ADP on reperfusion arrhythmias of rat hearts and electrical activity of canine Purkinje fibres
Authors
Issue Date1990
PublisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.org
Citation
Cardiovascular Research, 1990, v. 24 n. 8, p. 669-675 How to Cite?
AbstractThe aim was to evaluate the arrhythmogenic effect of a free radical generating system, FeCl 3/ADP, using two different approaches. Ventricular arrhythmias were studied in isolated rat hearts subjected to regional ischaemia and reperfusion without or with simultaneous treatment with nicergoline (0.4 mg·litre -1). In the second part of this study the electrophysiological effects of FeCl 3/ADP (0.1/1.0 μM) were investigated in normal Purkinje fibres and in Purkinje fibres from dog surviving infarction, by using conventional micro-electrode method. Hearts were obtained from male Sprague-Dawley rats, weight 250-300 g. Purkinje fibres were dissected from hearts of mongrel dogs of either sex (10-15 kg) with or without prior myocardial infarction. FeCl 3/ADP (0.1/1.0 μM and 1.0/1.0 μ M respectively) weakly changed the incidence of reperfusion induced arrhythmias. In nicergoline pretreated hearts, in which the incidence of reperfusion arrhythmias was reduced, FeCl 3/ADP (0.1/1.0 μM) did not change the incidence and the duration of reperfusion arrhythmias. In normal Purkinje fibres, FeCl 3/ADP(0.1/1.0μM) induced a decrease in action potential duration without any pronounced effect on V(max), diastolic potential, and activation potential. In Purkinje fibres from post infarct myocardium, FeCl 3/ADP decreased action potential duration, diastolic potential, and activation potential. Free radical generation did not antagonise the antiarrhythmic activity of α adrenergic blockade. Free radical generation induced slow and minor changes in electrophysiological activity of Purkinje fibres both from normal and ischaemic hearts. Our data suggest that free radical generation may not be the only mechanism involved in the genesis of reperfusion arrhythmias.
Persistent Identifierhttp://hdl.handle.net/10722/170966
ISSN
2015 Impact Factor: 5.465
2015 SCImago Journal Rankings: 2.897
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBril, Aen_US
dc.contributor.authorRochette, Len_US
dc.contributor.authorVerry, Aen_US
dc.contributor.authorMaupoil, Ven_US
dc.contributor.authorMan, RYKen_US
dc.contributor.authorOpie, LHen_US
dc.date.accessioned2012-10-30T06:11:38Z-
dc.date.available2012-10-30T06:11:38Z-
dc.date.issued1990en_US
dc.identifier.citationCardiovascular Research, 1990, v. 24 n. 8, p. 669-675en_US
dc.identifier.issn0008-6363en_US
dc.identifier.urihttp://hdl.handle.net/10722/170966-
dc.description.abstractThe aim was to evaluate the arrhythmogenic effect of a free radical generating system, FeCl 3/ADP, using two different approaches. Ventricular arrhythmias were studied in isolated rat hearts subjected to regional ischaemia and reperfusion without or with simultaneous treatment with nicergoline (0.4 mg·litre -1). In the second part of this study the electrophysiological effects of FeCl 3/ADP (0.1/1.0 μM) were investigated in normal Purkinje fibres and in Purkinje fibres from dog surviving infarction, by using conventional micro-electrode method. Hearts were obtained from male Sprague-Dawley rats, weight 250-300 g. Purkinje fibres were dissected from hearts of mongrel dogs of either sex (10-15 kg) with or without prior myocardial infarction. FeCl 3/ADP (0.1/1.0 μM and 1.0/1.0 μ M respectively) weakly changed the incidence of reperfusion induced arrhythmias. In nicergoline pretreated hearts, in which the incidence of reperfusion arrhythmias was reduced, FeCl 3/ADP (0.1/1.0 μM) did not change the incidence and the duration of reperfusion arrhythmias. In normal Purkinje fibres, FeCl 3/ADP(0.1/1.0μM) induced a decrease in action potential duration without any pronounced effect on V(max), diastolic potential, and activation potential. In Purkinje fibres from post infarct myocardium, FeCl 3/ADP decreased action potential duration, diastolic potential, and activation potential. Free radical generation did not antagonise the antiarrhythmic activity of α adrenergic blockade. Free radical generation induced slow and minor changes in electrophysiological activity of Purkinje fibres both from normal and ischaemic hearts. Our data suggest that free radical generation may not be the only mechanism involved in the genesis of reperfusion arrhythmias.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://cardiovascres.oxfordjournals.orgen_US
dc.relation.ispartofCardiovascular Researchen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAdenosine Diphosphate - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Etiologyen_US
dc.subject.meshChloridesen_US
dc.subject.meshFerric Compounds - Pharmacologyen_US
dc.subject.meshFree Radicalsen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction - Physiopathologyen_US
dc.subject.meshMyocardial Reperfusion Injury - Etiologyen_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.subject.meshPurkinje Fibers - Physiopathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleEffects of the free radical generating system FeCl 3/ADP on reperfusion arrhythmias of rat hearts and electrical activity of canine Purkinje fibresen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/cvr/24.8.669-
dc.identifier.pmid2224935-
dc.identifier.scopuseid_2-s2.0-0024992227en_US
dc.identifier.volume24en_US
dc.identifier.issue8en_US
dc.identifier.spage669en_US
dc.identifier.epage675en_US
dc.identifier.isiWOS:A1990DU07200011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBril, A=7006161753en_US
dc.identifier.scopusauthoridRochette, L=7005691376en_US
dc.identifier.scopusauthoridVerry, A=8965803000en_US
dc.identifier.scopusauthoridMaupoil, V=7004568342en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridOpie, LH=36051372200en_US

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