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Article: Heterogeneity of endothelium-dependent and independent responses among large and small porcine pulmonary arteries

TitleHeterogeneity of endothelium-dependent and independent responses among large and small porcine pulmonary arteries
Authors
Issue Date1989
Citation
Pulmonary Pharmacology, 1989, v. 2 n. 4, p. 201-208 How to Cite?
AbstractTo determine whether heterogeneity of endothelium-dependent or independent responsiveness exists between large and small pulmonary arteries, isolated rings (3-4 mm long) from large (5-7 mm in diameter) and small (2-3 mm in diameter) intralobar pulmonary arteries were prepared from normal swine and studied in vitro. Rings, with and without endothelium, were suspended in modified Krebs-Ringer bicarbonate solution, bubbled with 95% O2-5% CO2, maintained at 37°C and studied in parallel. Contractions to phenylephrine, norepinephrine and histamine were significantly potentiated in small rings, with or without endothelium, compared to large pulmonary artery rings with or without endothelium. The α-adrenergic agonist, UK 14304, however, caused comparable contractions in rings without endothelium taken from large and small vessels. Contractions to potassium chloride in rings without endothelium were also comparable. Relaxant responses were assessed in rings incubated with indomethacin and contracted with phenylephrine or prostaglanding F(2α). Acetylcholine, bradykinin, the calcium ionophore A23187 and UK 14304 elicited endothelium-dependent relaxations in rings from both large and small vessels. Relaxations induced by acetylcholine and bradykinin but not those by A23187 were significantly shifted downward in small versus large pulmonary-artery rings. Isoproterenol also caused endothelium-augmented relaxations but in rings from small vessels only. Sodium nitroprusside and nitric oxide caused similar relaxations in rings from both orders. These results demonstrate that a heterogeneity in endothelium-dependent and independent responsiveness exists between large and small pulmonary arteries.
Persistent Identifierhttp://hdl.handle.net/10722/170964
ISSN

 

DC FieldValueLanguage
dc.contributor.authorZellers, TMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:37Z-
dc.date.available2012-10-30T06:11:37Z-
dc.date.issued1989en_US
dc.identifier.citationPulmonary Pharmacology, 1989, v. 2 n. 4, p. 201-208en_US
dc.identifier.issn0952-0600en_US
dc.identifier.urihttp://hdl.handle.net/10722/170964-
dc.description.abstractTo determine whether heterogeneity of endothelium-dependent or independent responsiveness exists between large and small pulmonary arteries, isolated rings (3-4 mm long) from large (5-7 mm in diameter) and small (2-3 mm in diameter) intralobar pulmonary arteries were prepared from normal swine and studied in vitro. Rings, with and without endothelium, were suspended in modified Krebs-Ringer bicarbonate solution, bubbled with 95% O2-5% CO2, maintained at 37°C and studied in parallel. Contractions to phenylephrine, norepinephrine and histamine were significantly potentiated in small rings, with or without endothelium, compared to large pulmonary artery rings with or without endothelium. The α-adrenergic agonist, UK 14304, however, caused comparable contractions in rings without endothelium taken from large and small vessels. Contractions to potassium chloride in rings without endothelium were also comparable. Relaxant responses were assessed in rings incubated with indomethacin and contracted with phenylephrine or prostaglanding F(2α). Acetylcholine, bradykinin, the calcium ionophore A23187 and UK 14304 elicited endothelium-dependent relaxations in rings from both large and small vessels. Relaxations induced by acetylcholine and bradykinin but not those by A23187 were significantly shifted downward in small versus large pulmonary-artery rings. Isoproterenol also caused endothelium-augmented relaxations but in rings from small vessels only. Sodium nitroprusside and nitric oxide caused similar relaxations in rings from both orders. These results demonstrate that a heterogeneity in endothelium-dependent and independent responsiveness exists between large and small pulmonary arteries.en_US
dc.languageengen_US
dc.relation.ispartofPulmonary Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshPulmonary Artery - Drug Effects - Physiologyen_US
dc.subject.meshSwine - Physiologyen_US
dc.titleHeterogeneity of endothelium-dependent and independent responses among large and small porcine pulmonary arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0952-0600(89)90021-5en_US
dc.identifier.pmid2520500-
dc.identifier.scopuseid_2-s2.0-0024848970en_US
dc.identifier.volume2en_US
dc.identifier.issue4en_US
dc.identifier.spage201en_US
dc.identifier.epage208en_US
dc.identifier.scopusauthoridZellers, TM=6701423788en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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