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Article: Tetrodotoxin-insensitive relaxation of coronary arterial smooth muscle to electrical stimulation: Possible involvement of a dopaminergic mechanism

TitleTetrodotoxin-insensitive relaxation of coronary arterial smooth muscle to electrical stimulation: Possible involvement of a dopaminergic mechanism
Authors
Issue Date1989
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
Blood Vessels, 1989, v. 26 n. 4, p. 213-227 How to Cite?
AbstractExperiments were designed to determine the mechanism by which electrical stimulation causes tetrodotoxin-insensitive relaxation in isolated arteries. Rings of left anterior descending coronary arteries of dogs, pigs and calves were suspended in organ chambers between platinum electrodes. Experiments were performed after treatment with phenoxybenzamine and in the presence of propranolol. Calcium-free solution and calcium antagonists reduced the relaxation. Chemical denervation with 6-hydroxydopamine reduced the relaxation induced by electrical stimulation; in the presence of pargyline, the inhibitor of monoamine oxidase, it was virtually abolished. The nonselective dopaminergic antagonist droperidol and the selective DA1-dopaminergic antagonist SKF R83566 caused a concentration-dependent inhibition of the relaxation; the DA2-dopaminergic antagonist domperidone was ineffective. High concentrations of dopamine induced relaxation of the coronary smooth muscle; the relaxation was inhibited by SKF R83566 but not by droperidol. These results suggest that electrical stimulation causes relaxation by liberating an endogenous vasodilator substance, which acts on DA1-dopaminergic receptors of the coronary smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170963
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFeletou, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:37Z-
dc.date.available2012-10-30T06:11:37Z-
dc.date.issued1989en_US
dc.identifier.citationBlood Vessels, 1989, v. 26 n. 4, p. 213-227en_US
dc.identifier.issn0303-6847en_US
dc.identifier.urihttp://hdl.handle.net/10722/170963-
dc.description.abstractExperiments were designed to determine the mechanism by which electrical stimulation causes tetrodotoxin-insensitive relaxation in isolated arteries. Rings of left anterior descending coronary arteries of dogs, pigs and calves were suspended in organ chambers between platinum electrodes. Experiments were performed after treatment with phenoxybenzamine and in the presence of propranolol. Calcium-free solution and calcium antagonists reduced the relaxation. Chemical denervation with 6-hydroxydopamine reduced the relaxation induced by electrical stimulation; in the presence of pargyline, the inhibitor of monoamine oxidase, it was virtually abolished. The nonselective dopaminergic antagonist droperidol and the selective DA1-dopaminergic antagonist SKF R83566 caused a concentration-dependent inhibition of the relaxation; the DA2-dopaminergic antagonist domperidone was ineffective. High concentrations of dopamine induced relaxation of the coronary smooth muscle; the relaxation was inhibited by SKF R83566 but not by droperidol. These results suggest that electrical stimulation causes relaxation by liberating an endogenous vasodilator substance, which acts on DA1-dopaminergic receptors of the coronary smooth muscle.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVRen_US
dc.relation.ispartofBlood Vesselsen_US
dc.subject.mesh2,3,4,5-Tetrahydro-7,8-Dihydroxy-1-Phenyl-1H-3-Benzazepine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCattleen_US
dc.subject.meshCoronary Vessels - Drug Effects - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshDopamine - Pharmacologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHydroxydopamines - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidopamineen_US
dc.subject.meshReceptors, Dopamine - Physiologyen_US
dc.subject.meshScorpion Venoms - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshTetraethylammonium Compounds - Pharmacologyen_US
dc.subject.meshTetrodotoxin - Pharmacologyen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleTetrodotoxin-insensitive relaxation of coronary arterial smooth muscle to electrical stimulation: Possible involvement of a dopaminergic mechanismen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2515896-
dc.identifier.scopuseid_2-s2.0-0024845613en_US
dc.identifier.volume26en_US
dc.identifier.issue4en_US
dc.identifier.spage213en_US
dc.identifier.epage227en_US
dc.identifier.isiWOS:A1989CP62500003-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridFeletou, M=7006461826en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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