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Article: Cooling and alpha adrenergic responses in the saphenous vein of the rabbit

TitleCooling and alpha adrenergic responses in the saphenous vein of the rabbit
Authors
Issue Date1989
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1989, v. 249 n. 1, p. 56-60 How to Cite?
AbstractExperiments were designed to determine the effects of cooling on alpha-1 and alpha-2 adrenergic responses in a cutaneous vein of the rabbit. Rings of saphenous vein were suspended in physiological salt solution for the recording of isometric force. Cooling (from 37-24°C) caused no significant increase in force in quiescent rings. Similarly, the same degree of cooling had no significant effect on the response to exogenous norepinephrine (10-9-10-5 M), whether under control conditions or in the presence of either the alpha-1 adrenergic antagonist prazosin (3 x 10-7 M) or the alpha-2 adrenergic antagonist rauwolscine (10-7 M). Contractions evoked by the alpha-1 adrenergic agonist phenylephrine were reduced, but those induced by the alpha-2 adrenergic agonist UK 14,304 (10-9-10-5 M) were unaffected by the same degree of cooling. Cooling augmented the response elicited by electrical field stimulation of the sympathetic nerves, although only under conditions of alpha-1 or combined alpha-1 and alpha-2 adrenergic blockade. Data obtained with the sympathomimetic tyramine suggest that both alpha-1 and alpha-2 adrenoceptors are innervated in this blood vessel. Together, the present data suggest that the effects of acute cooling on the saphenous vein of the rabbit, unlike that of the dog, are not mediated by changes in the affinity of postjunctional alpha-2 adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/170952
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHarker, CTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:35Z-
dc.date.available2012-10-30T06:11:35Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1989, v. 249 n. 1, p. 56-60en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170952-
dc.description.abstractExperiments were designed to determine the effects of cooling on alpha-1 and alpha-2 adrenergic responses in a cutaneous vein of the rabbit. Rings of saphenous vein were suspended in physiological salt solution for the recording of isometric force. Cooling (from 37-24°C) caused no significant increase in force in quiescent rings. Similarly, the same degree of cooling had no significant effect on the response to exogenous norepinephrine (10-9-10-5 M), whether under control conditions or in the presence of either the alpha-1 adrenergic antagonist prazosin (3 x 10-7 M) or the alpha-2 adrenergic antagonist rauwolscine (10-7 M). Contractions evoked by the alpha-1 adrenergic agonist phenylephrine were reduced, but those induced by the alpha-2 adrenergic agonist UK 14,304 (10-9-10-5 M) were unaffected by the same degree of cooling. Cooling augmented the response elicited by electrical field stimulation of the sympathetic nerves, although only under conditions of alpha-1 or combined alpha-1 and alpha-2 adrenergic blockade. Data obtained with the sympathomimetic tyramine suggest that both alpha-1 and alpha-2 adrenoceptors are innervated in this blood vessel. Together, the present data suggest that the effects of acute cooling on the saphenous vein of the rabbit, unlike that of the dog, are not mediated by changes in the affinity of postjunctional alpha-2 adrenoceptors.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshTyramine - Pharmacologyen_US
dc.subject.meshVasoconstrictionen_US
dc.titleCooling and alpha adrenergic responses in the saphenous vein of the rabbiten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2540321en_US
dc.identifier.scopuseid_2-s2.0-0024537572en_US
dc.identifier.volume249en_US
dc.identifier.issue1en_US
dc.identifier.spage56en_US
dc.identifier.epage60en_US
dc.identifier.isiWOS:A1989U279300010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHarker, CT=7003742599en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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