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Article: Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries

TitleHypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries
Authors
Issue Date1989
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jvs
Citation
Journal Of Vascular Surgery, 1989, v. 10 n. 3, p. 318-325 How to Cite?
AbstractThe purpose of the present study was to examine in peripheral arteries whether the endothelium plays a protective role against aggregating platelets and whether the responses to platelets are altered by hypercholesterolemia. Male Yorkshire pigs were fed either a normal diet or a 2% high-cholesterol diet for 10 weeks. Endothelium-dependent responses were examined in vitro. In isolated iliac arteries from control animals, aggregating platelets caused contractions that were significantly inhibited by the endothelium. In rings with endothelium from pigs fed a cholesterol diet, the contractions were augmented and no difference was noted betwemen rings with and rings without endothelium. In rings taken from control pigs contracted with prostaglandin F(2α), aggregating platelets caused endothelium-dependent relaxations, which were attenuated by blockade of adenosine diphosphate or serotonin. Adenosine diphosphate and serotonin also caused endothelium-dependent relaxations. In arteries from cholesterol-fed animals, the inhibitory effects of the endothelium to aggregating platelets, adenosine diphosphate, and serotonin were impaired. These experiments indicate that in porcine iliac arteries the endothelium exerts inhibitory effects on the responses to aggregating platelets, which are mediated by adenosine diphosphate and serotonin released from platelets. Hypercholesterolemia impairs the endothelium-dependent relaxations to aggregating platelets caused by reduced relaxations to adenosine diphosphate and serotonin and unmasks the contractions evoked by aggregating platelets. This may increase the level of vascular tone, decrease blood flow and increase platelet aggregation, and eventually facilitate the occurrence of peripheral arterial occlusive disease.
Persistent Identifierhttp://hdl.handle.net/10722/170939
ISSN
2015 Impact Factor: 3.454
2015 SCImago Journal Rankings: 2.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKomori, Ken_US
dc.contributor.authorShimokawa, Hen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:31Z-
dc.date.available2012-10-30T06:11:31Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Vascular Surgery, 1989, v. 10 n. 3, p. 318-325en_US
dc.identifier.issn0741-5214en_US
dc.identifier.urihttp://hdl.handle.net/10722/170939-
dc.description.abstractThe purpose of the present study was to examine in peripheral arteries whether the endothelium plays a protective role against aggregating platelets and whether the responses to platelets are altered by hypercholesterolemia. Male Yorkshire pigs were fed either a normal diet or a 2% high-cholesterol diet for 10 weeks. Endothelium-dependent responses were examined in vitro. In isolated iliac arteries from control animals, aggregating platelets caused contractions that were significantly inhibited by the endothelium. In rings with endothelium from pigs fed a cholesterol diet, the contractions were augmented and no difference was noted betwemen rings with and rings without endothelium. In rings taken from control pigs contracted with prostaglandin F(2α), aggregating platelets caused endothelium-dependent relaxations, which were attenuated by blockade of adenosine diphosphate or serotonin. Adenosine diphosphate and serotonin also caused endothelium-dependent relaxations. In arteries from cholesterol-fed animals, the inhibitory effects of the endothelium to aggregating platelets, adenosine diphosphate, and serotonin were impaired. These experiments indicate that in porcine iliac arteries the endothelium exerts inhibitory effects on the responses to aggregating platelets, which are mediated by adenosine diphosphate and serotonin released from platelets. Hypercholesterolemia impairs the endothelium-dependent relaxations to aggregating platelets caused by reduced relaxations to adenosine diphosphate and serotonin and unmasks the contractions evoked by aggregating platelets. This may increase the level of vascular tone, decrease blood flow and increase platelet aggregation, and eventually facilitate the occurrence of peripheral arterial occlusive disease.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jvsen_US
dc.relation.ispartofJournal of Vascular Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshHypercholesterolemia - Physiopathologyen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle Relaxationen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiopathologyen_US
dc.subject.meshSwineen_US
dc.titleHypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1067/mva.1989.14005-
dc.identifier.pmid2778896-
dc.identifier.scopuseid_2-s2.0-0024445129en_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spage318en_US
dc.identifier.epage325en_US
dc.identifier.isiWOS:A1989AQ37900015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKomori, K=8977740100en_US
dc.identifier.scopusauthoridShimokawa, H=16684837100en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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