File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Alpha2-adrenoceptors and endothelium-derived relaxing factor

TitleAlpha2-adrenoceptors and endothelium-derived relaxing factor
Authors
Issue Date1989
PublisherExcerpta Medica, Inc. The Journal's web site is located at http://www.elsevier.com/locate/amj
Citation
American Journal Of Medicine, 1989, v. 87 n. 3 C, p. 1S-5S How to Cite?
AbstractThe endothelium can release potent vasodilator substances, in particular prostacyclin and endothelium-derived relaxing factor. The triggers for the release of endothelium-derived relaxing factor include increases in levels of shear stress, neurotransmitters, autacoids, platelet products, and hormones. The endothelium-dependent response to catecholamines involves stimulation of alpha2-adrenoceptors on the endothelial cells. Indeed, in a number of blood vessels, selective alpha2-adrenergic agonists cause endothelium-dependent relaxations. These are seen most typically in blood vessels with long-term exposure to high flows and high partial pressures of oxygen. In addition to the release of endothelium-derived relaxing factor, alpha2-adrenergic agonists can stimulate postjunctional (postsynaptic) alpha2-adrenoceptors on vascular smooth muscles. These receptors, which are more abundant in hypertensive blood vessels, activate the contractile process. However, the alpha2-adrenergic vasoconstrictors act as partial agonists (with a limited receptor reserve) and hence their vasoconstrictor response is very sensitive to functional antagonists such as endothelium-derived relaxing factor. Thus, the presence of endothelial cells can blunt the vasoconstrictor response to these substances not only because of an augmented release of endothelium-derived relaxing factor but also because the vasoconstriction that they induce is particularly susceptible to the inhibitory effect of the factor.
Persistent Identifierhttp://hdl.handle.net/10722/170938
ISSN
2015 Impact Factor: 5.61
2015 SCImago Journal Rankings: 2.023
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorMiller, VMen_US
dc.date.accessioned2012-10-30T06:11:30Z-
dc.date.available2012-10-30T06:11:30Z-
dc.date.issued1989en_US
dc.identifier.citationAmerican Journal Of Medicine, 1989, v. 87 n. 3 C, p. 1S-5Sen_US
dc.identifier.issn0002-9343en_US
dc.identifier.urihttp://hdl.handle.net/10722/170938-
dc.description.abstractThe endothelium can release potent vasodilator substances, in particular prostacyclin and endothelium-derived relaxing factor. The triggers for the release of endothelium-derived relaxing factor include increases in levels of shear stress, neurotransmitters, autacoids, platelet products, and hormones. The endothelium-dependent response to catecholamines involves stimulation of alpha2-adrenoceptors on the endothelial cells. Indeed, in a number of blood vessels, selective alpha2-adrenergic agonists cause endothelium-dependent relaxations. These are seen most typically in blood vessels with long-term exposure to high flows and high partial pressures of oxygen. In addition to the release of endothelium-derived relaxing factor, alpha2-adrenergic agonists can stimulate postjunctional (postsynaptic) alpha2-adrenoceptors on vascular smooth muscles. These receptors, which are more abundant in hypertensive blood vessels, activate the contractile process. However, the alpha2-adrenergic vasoconstrictors act as partial agonists (with a limited receptor reserve) and hence their vasoconstrictor response is very sensitive to functional antagonists such as endothelium-derived relaxing factor. Thus, the presence of endothelial cells can blunt the vasoconstrictor response to these substances not only because of an augmented release of endothelium-derived relaxing factor but also because the vasoconstriction that they induce is particularly susceptible to the inhibitory effect of the factor.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjen_US
dc.relation.ispartofAmerican Journal of Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Metabolism - Physiologyen_US
dc.subject.meshCatecholamines - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Metabolism - Physiologyen_US
dc.subject.meshNitric Oxideen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshVasodilationen_US
dc.titleAlpha2-adrenoceptors and endothelium-derived relaxing factoren_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0002-9343(89)90496-8-
dc.identifier.pmid2551167-
dc.identifier.scopuseid_2-s2.0-0024443813en_US
dc.identifier.volume87en_US
dc.identifier.issue3 Cen_US
dc.identifier.spage1Sen_US
dc.identifier.epage5Sen_US
dc.identifier.isiWOS:A1989AT66300001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridMiller, VM=7201476816en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats