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Article: Does acidosis contribute to stress-induced ulceration in rat stomachs?

TitleDoes acidosis contribute to stress-induced ulceration in rat stomachs?
Authors
Koo, MWLCho, CHOgle, CW
KeywordsAcidosis
Cold-restraint stress
Gastric ulcers
HCl
NaHCO3
Issue Date1989
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 1989, v. 33 n. 3, p. 563-566 How to Cite?
DOI: http://dx.doi.org/10.1016/0091-3057(89)90388-2
AbstractThe present study examines the involvement of acidosis in stress ulceration in rat stomachs. Cold restraint stress for 2 hr did not affect the blood lactate level; however, it produced respiratory acidosis, as reflected by the depressed respiratory rate which was associated with increased CO2 tension and a lowered blood pH. Severe hemorrhagic ulceration was found in the glandular mucosa. The effects of stress on blood pH and the stomach were reversed by IV infusion of NaHCO3. Infusion of HCl IV decreased the blood pH and HCO3 - level and produced gastric ulceration. It is concluded that respiratory acidosis could be involved in stress ulceration. The metabolic acidosis evoked by HCl also induced gastric damage, but the effect was much less.
Persistent Identifierhttp://hdl.handle.net/10722/170934
ISSN
0091-3057
2021 Impact Factor: 3.697
2020 SCImago Journal Rankings: 1.184
ISI Accession Number ID
WOS:A1989AQ70000013

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorOgle, CWen_US
dc.date.accessioned2012-10-30T06:11:29Z-
dc.date.available2012-10-30T06:11:29Z-
dc.date.issued1989en_US
dc.identifier.citationPharmacology Biochemistry And Behavior, 1989, v. 33 n. 3, p. 563-566en_US
dc.identifier.issn0091-3057en_US
dc.identifier.urihttp://hdl.handle.net/10722/170934-
dc.description.abstractThe present study examines the involvement of acidosis in stress ulceration in rat stomachs. Cold restraint stress for 2 hr did not affect the blood lactate level; however, it produced respiratory acidosis, as reflected by the depressed respiratory rate which was associated with increased CO2 tension and a lowered blood pH. Severe hemorrhagic ulceration was found in the glandular mucosa. The effects of stress on blood pH and the stomach were reversed by IV infusion of NaHCO3. Infusion of HCl IV decreased the blood pH and HCO3 - level and produced gastric ulceration. It is concluded that respiratory acidosis could be involved in stress ulceration. The metabolic acidosis evoked by HCl also induced gastric damage, but the effect was much less.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.subjectAcidosis-
dc.subjectCold-restraint stress-
dc.subjectGastric ulcers-
dc.subjectHCl-
dc.subjectNaHCO3-
dc.subject.meshAcidosis, Respiratory - Complications - Physiopathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBicarbonates - Blood - Pharmacologyen_US
dc.subject.meshCarbon Dioxide - Blooden_US
dc.subject.meshCold Temperature - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHydrochloric Acid - Adverse Effects - Pharmacologyen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshLactates - Blooden_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshRestraint, Physicalen_US
dc.subject.meshSodium - Pharmacologyen_US
dc.subject.meshSodium Bicarbonateen_US
dc.subject.meshStomach Ulcer - Etiologyen_US
dc.subject.meshStress, Physiological - Blood - Complications - Physiopathologyen_US
dc.titleDoes acidosis contribute to stress-induced ulceration in rat stomachs?en_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0091-3057(89)90388-2-
dc.identifier.pmid2555822-
dc.identifier.scopuseid_2-s2.0-0024420264en_US
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.spage563en_US
dc.identifier.epage566en_US
dc.identifier.isiWOS:A1989AQ70000013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US
dc.identifier.issnl0091-3057-

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