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Article: Endothelium and control of vascular function. State of the art lecture

TitleEndothelium and control of vascular function. State of the art lecture
Authors
Issue Date1989
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 1989, v. 13 n. 6 II, p. 658-667 How to Cite?
AbstractThe response of isolated blood vessels to a variety of vasoactive agonists is modulated by the presence of endothelial cells. Indeed, these cells can release both dilator and constrictor substances. The major endothelium-derived relaxing factor may be nitric oxide, which activates soluble guanylate cyclase in the smooth muscle, although the endothelial cells also secrete an unidentified hyperpolarizing factor. Among the natural stimuli for the release of endothelium-derived relaxing factors are circulating hormones, platelet products, thrombin, shear stress, and certain autacoids. Endothelium-derived relaxing factors may contribute to the regulation of the release of atrial natriuretic factor and renin. The endothelial cells can also release constricting factors; among the likely candidates are superoxide anions or the peptide endothelin. In hypertensive blood vessels, the ability to release endothelium-derived relaxing factors but not endothelium-derived contracting factors is blunted.
Persistent Identifierhttp://hdl.handle.net/10722/170919
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:25Z-
dc.date.available2012-10-30T06:11:25Z-
dc.date.issued1989en_US
dc.identifier.citationHypertension, 1989, v. 13 n. 6 II, p. 658-667en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170919-
dc.description.abstractThe response of isolated blood vessels to a variety of vasoactive agonists is modulated by the presence of endothelial cells. Indeed, these cells can release both dilator and constrictor substances. The major endothelium-derived relaxing factor may be nitric oxide, which activates soluble guanylate cyclase in the smooth muscle, although the endothelial cells also secrete an unidentified hyperpolarizing factor. Among the natural stimuli for the release of endothelium-derived relaxing factors are circulating hormones, platelet products, thrombin, shear stress, and certain autacoids. Endothelium-derived relaxing factors may contribute to the regulation of the release of atrial natriuretic factor and renin. The endothelial cells can also release constricting factors; among the likely candidates are superoxide anions or the peptide endothelin. In hypertensive blood vessels, the ability to release endothelium-derived relaxing factors but not endothelium-derived contracting factors is blunted.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Physiologyen_US
dc.subject.meshBlood Vessels - Drug Effects - Physiologyen_US
dc.subject.meshEndothelinsen_US
dc.subject.meshEndothelium, Vascular - Cytology - Metabolism - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Cytology - Physiologyen_US
dc.subject.meshNitric Oxideen_US
dc.subject.meshPeptides - Metabolism - Physiologyen_US
dc.subject.meshVasodilationen_US
dc.titleEndothelium and control of vascular function. State of the art lectureen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.HYP.13.6.658-
dc.identifier.pmid2661425-
dc.identifier.scopuseid_2-s2.0-0024360030en_US
dc.identifier.volume13en_US
dc.identifier.issue6 IIen_US
dc.identifier.spage658en_US
dc.identifier.epage667en_US
dc.identifier.isiWOS:A1989AA58200002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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