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Article: Aging and vascular responsiveness

TitleAging and vascular responsiveness
Authors
Issue Date1988
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1988, v. 12 SUPPL. 8, p. S11-S18 How to Cite?
AbstractWith aging, the blood vessel wall becomes hyperreactive - presumably because of an augmented vasoconstrictor and a reduced vasodilator responsiveness. Autonomic nerves, vascular smooth muscle, and endothelial cells may contribute to these changes. It seems unlikely that augmented vasoconstriction following α-adrenergic activation plays a major role in the increased peripheral resistance seen in the elderly human. There are no major age-related changes in the responsiveness of vascular smooth muscle to angiotensin II, histamine, or potassium chloride. By contrast, the vasoconstrictor effects of 5-hydroxytryptamine (serotonin) are augmented, and the tachyphylaxis to the monoamine is reduced with aging. There are no indications of a major abnormality in either response to vasodilator nerves or endothelium-dependent vasodilators. However, the α-adrenergic responsiveness of most arteries is reduced, whereas that of the veins is not affected by age. When it is exposed to agents acting directly, arterial smooth muscle's ability to relax is not altered with senescence. Thus, the augmented responsiveness to the vasoconstrictor effects of serotonin and the reduced response to the β-adrenergic dilator effects of catecholamines appear to be the hallmark of aging in the precapillary vessels.
Persistent Identifierhttp://hdl.handle.net/10722/170915
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:25Z-
dc.date.available2012-10-30T06:11:25Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1988, v. 12 SUPPL. 8, p. S11-S18en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170915-
dc.description.abstractWith aging, the blood vessel wall becomes hyperreactive - presumably because of an augmented vasoconstrictor and a reduced vasodilator responsiveness. Autonomic nerves, vascular smooth muscle, and endothelial cells may contribute to these changes. It seems unlikely that augmented vasoconstriction following α-adrenergic activation plays a major role in the increased peripheral resistance seen in the elderly human. There are no major age-related changes in the responsiveness of vascular smooth muscle to angiotensin II, histamine, or potassium chloride. By contrast, the vasoconstrictor effects of 5-hydroxytryptamine (serotonin) are augmented, and the tachyphylaxis to the monoamine is reduced with aging. There are no indications of a major abnormality in either response to vasodilator nerves or endothelium-dependent vasodilators. However, the α-adrenergic responsiveness of most arteries is reduced, whereas that of the veins is not affected by age. When it is exposed to agents acting directly, arterial smooth muscle's ability to relax is not altered with senescence. Thus, the augmented responsiveness to the vasoconstrictor effects of serotonin and the reduced response to the β-adrenergic dilator effects of catecholamines appear to be the hallmark of aging in the precapillary vessels.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiovascular Physiological Phenomenaen_US
dc.subject.meshHumansen_US
dc.titleAging and vascular responsivenessen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198812081-00004-
dc.identifier.pmid2469892-
dc.identifier.scopuseid_2-s2.0-0024271322en_US
dc.identifier.volume12en_US
dc.identifier.issueSUPPL. 8en_US
dc.identifier.spageS11en_US
dc.identifier.epageS18en_US
dc.identifier.isiWOS:A1988T261600003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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