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Article: High potassium diet augments endothelium-dependent relaxations in the Dahl rat

TitleHigh potassium diet augments endothelium-dependent relaxations in the Dahl rat
Authors
Issue Date1988
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 1988, v. 12 n. 6, p. 562-567 How to Cite?
AbstractEndothelium-dependent relaxations are reduced in hypertensive rats. High dietary potassium supplementation reduce the incidence of strokes in Dahl rats indepedently of blood pressure, thereby suggesting a direct protective effect of the diet. Endothelium-dependent relaxations and aortic vascular architecture were studied in Dahl salt-sensitive rats fed 8% NaCl, 0.1% NaCl, or 8% NaCl plus 3.6% potassium citrate for 8 weeks. Rats fed 8% NaCl or 8% NaCl plus 3.6% potassium citrate became hypertensive, while those fed 0.1% NaCl did not. Aortic rings with and without endothelium were suspended in organ chambers filled with physiological salt solution (37°C) and aerated with 95% O2, 5% CO2. In rings contracted with norepinephrine, acetylcholine and adenosine 5'-diphosphate caused endothelium-dependent relaxations that were significantly reduced in rats fed 8% NaCl as compared with those fed 0.1% NaCl. Potassium supplementation (8% NaCl/3.6% potassium citrate) significantly enhanced relaxations to acetylcholine in salt-sensitive rats, while those to adenosine 5'-diphosphate and thrombin were either minimally affected or unchanged. Relaxations to sodium nitroprusside were similar in rats with or without potassium supplementation. Hypertension significantly increased aortic medial and intimal thickness. Dietary potassium had no significant effect on the vascular architecture. These results suggest that high potassium diet enhances endothelium-dependent relaxations in Dahl rats at least in part independently of change in blood pressure. Thus, potassium may be important for its protective effect against stroke and renal damage in this animal model of hypertension.
Persistent Identifierhttp://hdl.handle.net/10722/170913
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRaij, Len_US
dc.contributor.authorLuscher, TFen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:24Z-
dc.date.available2012-10-30T06:11:24Z-
dc.date.issued1988en_US
dc.identifier.citationHypertension, 1988, v. 12 n. 6, p. 562-567en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170913-
dc.description.abstractEndothelium-dependent relaxations are reduced in hypertensive rats. High dietary potassium supplementation reduce the incidence of strokes in Dahl rats indepedently of blood pressure, thereby suggesting a direct protective effect of the diet. Endothelium-dependent relaxations and aortic vascular architecture were studied in Dahl salt-sensitive rats fed 8% NaCl, 0.1% NaCl, or 8% NaCl plus 3.6% potassium citrate for 8 weeks. Rats fed 8% NaCl or 8% NaCl plus 3.6% potassium citrate became hypertensive, while those fed 0.1% NaCl did not. Aortic rings with and without endothelium were suspended in organ chambers filled with physiological salt solution (37°C) and aerated with 95% O2, 5% CO2. In rings contracted with norepinephrine, acetylcholine and adenosine 5'-diphosphate caused endothelium-dependent relaxations that were significantly reduced in rats fed 8% NaCl as compared with those fed 0.1% NaCl. Potassium supplementation (8% NaCl/3.6% potassium citrate) significantly enhanced relaxations to acetylcholine in salt-sensitive rats, while those to adenosine 5'-diphosphate and thrombin were either minimally affected or unchanged. Relaxations to sodium nitroprusside were similar in rats with or without potassium supplementation. Hypertension significantly increased aortic medial and intimal thickness. Dietary potassium had no significant effect on the vascular architecture. These results suggest that high potassium diet enhances endothelium-dependent relaxations in Dahl rats at least in part independently of change in blood pressure. Thus, potassium may be important for its protective effect against stroke and renal damage in this animal model of hypertension.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Biosynthesisen_US
dc.subject.meshBlood Vessels - Pathologyen_US
dc.subject.meshDieten_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNitric Oxideen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium - Administration & Dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleHigh potassium diet augments endothelium-dependent relaxations in the Dahl raten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.HYP.12.6.562-
dc.identifier.pmid3264544-
dc.identifier.scopuseid_2-s2.0-0024262670en_US
dc.identifier.volume12en_US
dc.identifier.issue6en_US
dc.identifier.spage562en_US
dc.identifier.epage567en_US
dc.identifier.isiWOS:A1988R661200005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRaij, L=7006228846en_US
dc.identifier.scopusauthoridLuscher, TF=18935805600en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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