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- Publisher Website: 10.1111/j.1476-5381.1988.tb11756.x
- Scopus: eid_2-s2.0-0024209706
- PMID: 3064855
- WOS: WOS:A1988R301500026
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Article: Prostacyclin releases endothelium-derived relaxing factor and potentiates its action in coronary arteries of the pig
Title | Prostacyclin releases endothelium-derived relaxing factor and potentiates its action in coronary arteries of the pig |
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Authors | |
Issue Date | 1988 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 |
Citation | British Journal Of Pharmacology, 1988, v. 95 n. 4, p. 1197-1203 How to Cite? |
Abstract | The possible interactions between prostacyclin and endothelium-derived relaxing factor were examined, in isolated coronary arteries of the pig treated with indomethacin (10-5 M). In organ chamber experiments, prostacyclin caused relaxations, which were potentiated in the presence of the endothelium; the potentiation was abolished by oxyhaemoglobin. In bioassay experiments, prostacyclin caused minimal relaxations of bioassay rings without endothelium; these relaxations were potentiated when the bioassay ring was exposed to basally-released endothelium-derived relaxing factor (interaction between prostacyclin and basal endothelium-derived relaxing factor) and further augmented when the endothelial cells were exposed to the prostanoid (stimulated release of endothelium-derived relaxing factor). The endothelium-dependent, but not the direct effects of prostacyclin were augmented by superoxide dismutase plus catalase and abolished by oxyhaemoglobin. Forskolin, a direct activator of adenylate cyclase, caused relaxations of rings without endothelium, which were augmented by the presence of the endothelium. The relaxations induced by prostacyclin or forskolin also had an endothelium-dependent component in basilar and femoral arteries and in jugular veins of the pig. The endothelium-dependent actions of prostacyclin probably reflect activation of adenylate cyclase. |
Persistent Identifier | http://hdl.handle.net/10722/170907 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 2.119 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shimokawa, H | en_US |
dc.contributor.author | Flavahan, NA | en_US |
dc.contributor.author | Lorenz, RR | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:23Z | - |
dc.date.available | 2012-10-30T06:11:23Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | British Journal Of Pharmacology, 1988, v. 95 n. 4, p. 1197-1203 | en_US |
dc.identifier.issn | 0007-1188 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170907 | - |
dc.description.abstract | The possible interactions between prostacyclin and endothelium-derived relaxing factor were examined, in isolated coronary arteries of the pig treated with indomethacin (10-5 M). In organ chamber experiments, prostacyclin caused relaxations, which were potentiated in the presence of the endothelium; the potentiation was abolished by oxyhaemoglobin. In bioassay experiments, prostacyclin caused minimal relaxations of bioassay rings without endothelium; these relaxations were potentiated when the bioassay ring was exposed to basally-released endothelium-derived relaxing factor (interaction between prostacyclin and basal endothelium-derived relaxing factor) and further augmented when the endothelial cells were exposed to the prostanoid (stimulated release of endothelium-derived relaxing factor). The endothelium-dependent, but not the direct effects of prostacyclin were augmented by superoxide dismutase plus catalase and abolished by oxyhaemoglobin. Forskolin, a direct activator of adenylate cyclase, caused relaxations of rings without endothelium, which were augmented by the presence of the endothelium. The relaxations induced by prostacyclin or forskolin also had an endothelium-dependent component in basilar and femoral arteries and in jugular veins of the pig. The endothelium-dependent actions of prostacyclin probably reflect activation of adenylate cyclase. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 | en_US |
dc.relation.ispartof | British Journal of Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Factors - Secretion | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects - Physiology | en_US |
dc.subject.mesh | Endothelium, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Epoprostenol - Pharmacology | en_US |
dc.subject.mesh | Forskolin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Nitric Oxide | en_US |
dc.subject.mesh | Swine | en_US |
dc.title | Prostacyclin releases endothelium-derived relaxing factor and potentiates its action in coronary arteries of the pig | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1476-5381.1988.tb11756.x | - |
dc.identifier.pmid | 3064855 | - |
dc.identifier.scopus | eid_2-s2.0-0024209706 | en_US |
dc.identifier.volume | 95 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 1197 | en_US |
dc.identifier.epage | 1203 | en_US |
dc.identifier.isi | WOS:A1988R301500026 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Shimokawa, H=16684837100 | en_US |
dc.identifier.scopusauthorid | Flavahan, NA=7006398882 | en_US |
dc.identifier.scopusauthorid | Lorenz, RR=7402095192 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0007-1188 | - |