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Article: Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery

TitleComparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery
Authors
Issue Date1988
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1988, v. 244 n. 1, p. 1-10 How to Cite?
AbstractTo characterize the responses of the canine coronary artery to serotonin, rings with and without endothelium were suspended in organ chambers for isometric tension recording. Serotonin evoked an endothelium-dependent relaxation of prostaglandin F(2α)-contracted rings which was inhibited by antagonists with affinity for 5-hydroxytryptamine (5-HT)1 and 5-HT2 receptors, methiothepin and metergoline, but was not mimicked or antagonized by the 5-HT(1A)-selective ligand, 8-hydroxy-2-di-n-propylamino tetralin. This relaxation is not mediated by 5-HT(1B) receptors as it was not antagonized by cyanopindolol; similarly, lack of inhibition by ketanserin and MDL 72222 rule out contributions of 5-HT2 receptors or 5-HT3 receptors. Rings without endothelium contracted to serotonin; this contraction was not blocked by cyanopindolol and was only weakly inhibited by ketanserin, but was antagonized in an apparently competitive fashion by methiothepin and was mimicked by 8-hydroxy-2-di-n-propylamino tetralin (although at higher concentrations than would be expected for its action at a 5-HT(1A) receptor). At high concentrations, serotonin evoked a relaxation of endothelium-denuded rings, which was blocked by very low concentrations of methiothepin but was unaffected by ketanserin or cyanopindolol. Thus, there appear to be three different serotonergic receptors in the coronary artery. Although available agents do not allow their precise classification as yet, none of them is of the 5-HT2 type.
Persistent Identifierhttp://hdl.handle.net/10722/170899
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHouston, DSen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:20Z-
dc.date.available2012-10-30T06:11:20Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1988, v. 244 n. 1, p. 1-10en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170899-
dc.description.abstractTo characterize the responses of the canine coronary artery to serotonin, rings with and without endothelium were suspended in organ chambers for isometric tension recording. Serotonin evoked an endothelium-dependent relaxation of prostaglandin F(2α)-contracted rings which was inhibited by antagonists with affinity for 5-hydroxytryptamine (5-HT)1 and 5-HT2 receptors, methiothepin and metergoline, but was not mimicked or antagonized by the 5-HT(1A)-selective ligand, 8-hydroxy-2-di-n-propylamino tetralin. This relaxation is not mediated by 5-HT(1B) receptors as it was not antagonized by cyanopindolol; similarly, lack of inhibition by ketanserin and MDL 72222 rule out contributions of 5-HT2 receptors or 5-HT3 receptors. Rings without endothelium contracted to serotonin; this contraction was not blocked by cyanopindolol and was only weakly inhibited by ketanserin, but was antagonized in an apparently competitive fashion by methiothepin and was mimicked by 8-hydroxy-2-di-n-propylamino tetralin (although at higher concentrations than would be expected for its action at a 5-HT(1A) receptor). At high concentrations, serotonin evoked a relaxation of endothelium-denuded rings, which was blocked by very low concentrations of methiothepin but was unaffected by ketanserin or cyanopindolol. Thus, there appear to be three different serotonergic receptors in the coronary artery. Although available agents do not allow their precise classification as yet, none of them is of the 5-HT2 type.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.mesh8-Hydroxy-2-(Di-N-Propylamino)Tetralinen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Vesselsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEndothelium, Vascular - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshKetanserin - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMetergoline - Pharmacologyen_US
dc.subject.meshMethiothepin - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Analysisen_US
dc.subject.meshPindolol - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshReceptors, Serotonin - Drug Effects - Metabolismen_US
dc.subject.meshTetrahydronaphthalenes - Pharmacologyen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleComparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary arteryen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2961880-
dc.identifier.scopuseid_2-s2.0-0023911314en_US
dc.identifier.volume244en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
dc.identifier.isiWOS:A1988L779600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHouston, DS=35966326400en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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