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- Scopus: eid_2-s2.0-0023911314
- PMID: 2961880
- WOS: WOS:A1988L779600001
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Article: Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery
Title | Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery |
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Authors | |
Issue Date | 1988 |
Publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org |
Citation | Journal Of Pharmacology And Experimental Therapeutics, 1988, v. 244 n. 1, p. 1-10 How to Cite? |
Abstract | To characterize the responses of the canine coronary artery to serotonin, rings with and without endothelium were suspended in organ chambers for isometric tension recording. Serotonin evoked an endothelium-dependent relaxation of prostaglandin F(2α)-contracted rings which was inhibited by antagonists with affinity for 5-hydroxytryptamine (5-HT)1 and 5-HT2 receptors, methiothepin and metergoline, but was not mimicked or antagonized by the 5-HT(1A)-selective ligand, 8-hydroxy-2-di-n-propylamino tetralin. This relaxation is not mediated by 5-HT(1B) receptors as it was not antagonized by cyanopindolol; similarly, lack of inhibition by ketanserin and MDL 72222 rule out contributions of 5-HT2 receptors or 5-HT3 receptors. Rings without endothelium contracted to serotonin; this contraction was not blocked by cyanopindolol and was only weakly inhibited by ketanserin, but was antagonized in an apparently competitive fashion by methiothepin and was mimicked by 8-hydroxy-2-di-n-propylamino tetralin (although at higher concentrations than would be expected for its action at a 5-HT(1A) receptor). At high concentrations, serotonin evoked a relaxation of endothelium-denuded rings, which was blocked by very low concentrations of methiothepin but was unaffected by ketanserin or cyanopindolol. Thus, there appear to be three different serotonergic receptors in the coronary artery. Although available agents do not allow their precise classification as yet, none of them is of the 5-HT2 type. |
Persistent Identifier | http://hdl.handle.net/10722/170899 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.829 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Houston, DS | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:20Z | - |
dc.date.available | 2012-10-30T06:11:20Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Journal Of Pharmacology And Experimental Therapeutics, 1988, v. 244 n. 1, p. 1-10 | en_US |
dc.identifier.issn | 0022-3565 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170899 | - |
dc.description.abstract | To characterize the responses of the canine coronary artery to serotonin, rings with and without endothelium were suspended in organ chambers for isometric tension recording. Serotonin evoked an endothelium-dependent relaxation of prostaglandin F(2α)-contracted rings which was inhibited by antagonists with affinity for 5-hydroxytryptamine (5-HT)1 and 5-HT2 receptors, methiothepin and metergoline, but was not mimicked or antagonized by the 5-HT(1A)-selective ligand, 8-hydroxy-2-di-n-propylamino tetralin. This relaxation is not mediated by 5-HT(1B) receptors as it was not antagonized by cyanopindolol; similarly, lack of inhibition by ketanserin and MDL 72222 rule out contributions of 5-HT2 receptors or 5-HT3 receptors. Rings without endothelium contracted to serotonin; this contraction was not blocked by cyanopindolol and was only weakly inhibited by ketanserin, but was antagonized in an apparently competitive fashion by methiothepin and was mimicked by 8-hydroxy-2-di-n-propylamino tetralin (although at higher concentrations than would be expected for its action at a 5-HT(1A) receptor). At high concentrations, serotonin evoked a relaxation of endothelium-denuded rings, which was blocked by very low concentrations of methiothepin but was unaffected by ketanserin or cyanopindolol. Thus, there appear to be three different serotonergic receptors in the coronary artery. Although available agents do not allow their precise classification as yet, none of them is of the 5-HT2 type. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org | en_US |
dc.relation.ispartof | Journal of Pharmacology and Experimental Therapeutics | en_US |
dc.subject.mesh | 8-Hydroxy-2-(Di-N-Propylamino)Tetralin | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coronary Vessels | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Endothelium, Vascular - Analysis | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Ketanserin - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Metergoline - Pharmacology | en_US |
dc.subject.mesh | Methiothepin - Pharmacology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Analysis | en_US |
dc.subject.mesh | Pindolol - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Receptors, Serotonin - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Tetrahydronaphthalenes - Pharmacology | en_US |
dc.subject.mesh | Vasodilation - Drug Effects | en_US |
dc.title | Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 2961880 | - |
dc.identifier.scopus | eid_2-s2.0-0023911314 | en_US |
dc.identifier.volume | 244 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 10 | en_US |
dc.identifier.isi | WOS:A1988L779600001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Houston, DS=35966326400 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0022-3565 | - |