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Article: Cooling the central ear artery of the rabbit: Myogenic and adrenergic responses

TitleCooling the central ear artery of the rabbit: Myogenic and adrenergic responses
Authors
Issue Date1988
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1988, v. 245 n. 1, p. 89-93 How to Cite?
AbstractExperiments were designed to determine the effects of acute cooling (from 37-24°C) on responses to alpha-1 and alpha-2 adrenergic activation in the central ear artery of the rabbit. Rings were suspended in physiological salt solution for recording of isometric force. Cooling quiescent vessels resulted in an increase in force. This myogenic response was sensitive to depletion of either intra- or extracellular calcium, as well as treatment with the calcium antagonists verapamil and diltiazem. Cooling did not significantly alter contractile responses to norepinephrine in ear arteries under control conditions or under alpha-2 adrenergic blockade (rauwolscine). Cooling arteries under alpha-1 adrenergic blockade (prazosin) caused augmentations which were not significantly different in magnitude from the myogenic responses to cooling exhibited by the same rings when unstimulated. The alpha-1 adrenergic agonist phenylephrine caused concentration-dependent contractions which were not altered by cooling. The alpha-2 adrenergic agonist UK 14,304 evoked only weak contractions; cooling rings exposed to UK 14,304 caused further increases in tension but no more so than when quiescent. A similar pattern was seen to hold for contractions elicited by electrical stimulation. Thus, in the central ear artery of the rabbit cooling appears to have very little effect on adrenergically induced contractions but does cause the development of myogenic tone.
Persistent Identifierhttp://hdl.handle.net/10722/170897
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHarker, CTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:20Z-
dc.date.available2012-10-30T06:11:20Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1988, v. 245 n. 1, p. 89-93en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170897-
dc.description.abstractExperiments were designed to determine the effects of acute cooling (from 37-24°C) on responses to alpha-1 and alpha-2 adrenergic activation in the central ear artery of the rabbit. Rings were suspended in physiological salt solution for recording of isometric force. Cooling quiescent vessels resulted in an increase in force. This myogenic response was sensitive to depletion of either intra- or extracellular calcium, as well as treatment with the calcium antagonists verapamil and diltiazem. Cooling did not significantly alter contractile responses to norepinephrine in ear arteries under control conditions or under alpha-2 adrenergic blockade (rauwolscine). Cooling arteries under alpha-1 adrenergic blockade (prazosin) caused augmentations which were not significantly different in magnitude from the myogenic responses to cooling exhibited by the same rings when unstimulated. The alpha-1 adrenergic agonist phenylephrine caused concentration-dependent contractions which were not altered by cooling. The alpha-2 adrenergic agonist UK 14,304 evoked only weak contractions; cooling rings exposed to UK 14,304 caused further increases in tension but no more so than when quiescent. A similar pattern was seen to hold for contractions elicited by electrical stimulation. Thus, in the central ear artery of the rabbit cooling appears to have very little effect on adrenergically induced contractions but does cause the development of myogenic tone.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAdenosine Triphosphate - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Physiologyen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshEar - Blood Supplyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshTetrodotoxin - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titleCooling the central ear artery of the rabbit: Myogenic and adrenergic responsesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2834548-
dc.identifier.scopuseid_2-s2.0-0023910287en_US
dc.identifier.volume245en_US
dc.identifier.issue1en_US
dc.identifier.spage89en_US
dc.identifier.epage93en_US
dc.identifier.isiWOS:A1988N091600014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHarker, CT=7003742599en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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