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Article: Lysophosphatidylcholine metabolism and cardiac arrhythmias

TitleLysophosphatidylcholine metabolism and cardiac arrhythmias
Authors
Issue Date1988
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
Citation
Canadian Journal Of Physiology And Pharmacology, 1988, v. 66 n. 3, p. 185-189 How to Cite?
AbstractThe ability of exogenous lysophosphatidylcholine (LPC) to produce electrophysiological abnormalities in cardiac tissues and cardiac arrhythmias in isolated hearts has been well documented. In this study, the arrhythmogenic nature of LPC in the rat, rabbit, and guinea pig hearts was studied. The rat heart was found to be the most susceptible to LPC-induced arrhythmias, while the guinea pig heart was the least susceptible. Perfusion with labelled LPC revealed that the severity of arrhythmias correlates well with the amount of labelled LPC found in the microsomal membrane. The biochemical basis for the differences in the accumulation of LPC in the microsomal membrane of different animal species was investigated. Our results strongly indicate that the LPC level in the microsomal membrane may be regulated by the activity of microsomal lysophospholipase.
Persistent Identifierhttp://hdl.handle.net/10722/170894
ISSN
2015 Impact Factor: 1.704
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGiffin, Men_US
dc.contributor.authorArthur, Gen_US
dc.contributor.authorChoy, PCen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:19Z-
dc.date.available2012-10-30T06:11:19Z-
dc.date.issued1988en_US
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 1988, v. 66 n. 3, p. 185-189en_US
dc.identifier.issn0008-4212en_US
dc.identifier.urihttp://hdl.handle.net/10722/170894-
dc.description.abstractThe ability of exogenous lysophosphatidylcholine (LPC) to produce electrophysiological abnormalities in cardiac tissues and cardiac arrhythmias in isolated hearts has been well documented. In this study, the arrhythmogenic nature of LPC in the rat, rabbit, and guinea pig hearts was studied. The rat heart was found to be the most susceptible to LPC-induced arrhythmias, while the guinea pig heart was the least susceptible. Perfusion with labelled LPC revealed that the severity of arrhythmias correlates well with the amount of labelled LPC found in the microsomal membrane. The biochemical basis for the differences in the accumulation of LPC in the microsomal membrane of different animal species was investigated. Our results strongly indicate that the LPC level in the microsomal membrane may be regulated by the activity of microsomal lysophospholipase.en_US
dc.languageengen_US
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjppen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Chemically Induced - Metabolismen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshLysophosphatidylcholines - Adverse Effects - Metabolismen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.titleLysophosphatidylcholine metabolism and cardiac arrhythmiasen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1139/y88-032-
dc.identifier.pmid3383014-
dc.identifier.scopuseid_2-s2.0-0023893751en_US
dc.identifier.volume66en_US
dc.identifier.issue3en_US
dc.identifier.spage185en_US
dc.identifier.epage189en_US
dc.identifier.isiWOS:A1988M772800002-
dc.publisher.placeCanadaen_US
dc.identifier.scopusauthoridGiffin, M=6601942086en_US
dc.identifier.scopusauthoridArthur, G=7102560612en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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