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Article: Endothelium-dependent hyperpolarization of canine coronary smooth muscle

TitleEndothelium-dependent hyperpolarization of canine coronary smooth muscle
Authors
Issue Date1988
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 1988, v. 93 n. 3, p. 515-524 How to Cite?
Abstract1. Experiments were designed to determine whether endothelium-dependent relaxing factor(s) released by acetylcholine from the canine femoral artery influences the membrane potential of coronary arterial smooth muscle. 2. The membrane potential was recorded in small canine coronary arteries (internal diameter ≤ 500 μm; without endothelium) by means of intracellular microelectrodes. The organ bath also contained a strip of left descending coronary artery without endothelium in which isometric force was measured to bioassay relaxing factor(s) as well as segments of femoral artery with endothelium, which served as the source of endothelium-derived relaxing factor(s). 3. Acetylcholine induced endothelium-dependent, transient hyperpolarizations and relaxations that were not affected by indomethacin. 4. Inhibition of the sodium-potassium pump by ouabain or potassium-free solution did not inhibit the relaxation to acetylcholine but prevented the corresponding hyperpolarization. 5. Activation of the sodium-potassium pump of the smooth muscle cells by readmission of potassium ions after incubation in potassium-free solution caused relaxation and marked hyperpolarization. 6. These results suggest that endothelium-derived relaxing factor(s) induces hyperpolarization of vascular smooth muscle of the canine coronary artery, possibly by activation of sodium-potassium pumping, but that this effect on the cell membrane may only partially explain endothelium-dependent relaxations evoked by acetylcholine.
Persistent Identifierhttp://hdl.handle.net/10722/170891
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFeletou, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:18Z-
dc.date.available2012-10-30T06:11:18Z-
dc.date.issued1988en_US
dc.identifier.citationBritish Journal Of Pharmacology, 1988, v. 93 n. 3, p. 515-524en_US
dc.identifier.issn0007-1188en_US
dc.identifier.urihttp://hdl.handle.net/10722/170891-
dc.description.abstract1. Experiments were designed to determine whether endothelium-dependent relaxing factor(s) released by acetylcholine from the canine femoral artery influences the membrane potential of coronary arterial smooth muscle. 2. The membrane potential was recorded in small canine coronary arteries (internal diameter ≤ 500 μm; without endothelium) by means of intracellular microelectrodes. The organ bath also contained a strip of left descending coronary artery without endothelium in which isometric force was measured to bioassay relaxing factor(s) as well as segments of femoral artery with endothelium, which served as the source of endothelium-derived relaxing factor(s). 3. Acetylcholine induced endothelium-dependent, transient hyperpolarizations and relaxations that were not affected by indomethacin. 4. Inhibition of the sodium-potassium pump by ouabain or potassium-free solution did not inhibit the relaxation to acetylcholine but prevented the corresponding hyperpolarization. 5. Activation of the sodium-potassium pump of the smooth muscle cells by readmission of potassium ions after incubation in potassium-free solution caused relaxation and marked hyperpolarization. 6. These results suggest that endothelium-derived relaxing factor(s) induces hyperpolarization of vascular smooth muscle of the canine coronary artery, possibly by activation of sodium-potassium pumping, but that this effect on the cell membrane may only partially explain endothelium-dependent relaxations evoked by acetylcholine.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Agents - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshIon Channels - Drug Effectsen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNitric Oxideen_US
dc.subject.meshPotassium - Metabolismen_US
dc.subject.meshSodium - Metabolismen_US
dc.subject.meshTetraethylammoniumen_US
dc.subject.meshTetraethylammonium Compounds - Pharmacologyen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleEndothelium-dependent hyperpolarization of canine coronary smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1476-5381.1988.tb10306.x-
dc.identifier.pmid2453240en_US
dc.identifier.scopuseid_2-s2.0-0023867044en_US
dc.identifier.volume93en_US
dc.identifier.issue3en_US
dc.identifier.spage515en_US
dc.identifier.epage524en_US
dc.identifier.isiWOS:A1988M347400007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridFeletou, M=7006461826en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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