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- Publisher Website: 10.1111/j.1476-5381.1988.tb11448.x
- Scopus: eid_2-s2.0-0023850028
- PMID: 3359113
- WOS: WOS:A1988M073500022
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Article: Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart
Title | Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart |
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Authors | |
Issue Date | 1988 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 |
Citation | British Journal Of Pharmacology, 1988, v. 93 n. 2, p. 412-416 How to Cite? |
Abstract | 1. The tissue level of lysophosphatidylcholine (LPC) was determined in rat hearts perfused with a solution containing 5 μM LPC. The relationship between LPC accumulation and the severity of arrhythmias produced was examined. 2. The accumulation of LPC was dependent on the perfusion time and this accumulation was associated with the occurrence of severe arrhythmias. A positive correlation between the tissue LPC content and the arrhythmia score was found (P < 0.01). 3. No consistent alteration in total phospholipid, phosphatidylcholine or cholesterol content was found. This suggests that LPC-induced arrhythmias are not associated with alterations of major lipid components in the heart. 4. When severe arrhythmias occurred in the presence of LPC in the rat perfused heart, less than 2% of total tissue phospholipid was in the form of LPC. 5. The positive correlation between LPC accumulation and the occurrence of arrhythmias suggests a cause and effect relationship of LPC with cardiac arrhythmias in the rat perfused heart. However, in the ischaemic heart, other biochemical factors can contribute, to different degrees, to ischaemia-induced cardiac arrhythmias. |
Persistent Identifier | http://hdl.handle.net/10722/170889 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 2.119 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:11:18Z | - |
dc.date.available | 2012-10-30T06:11:18Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | British Journal Of Pharmacology, 1988, v. 93 n. 2, p. 412-416 | en_US |
dc.identifier.issn | 0007-1188 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170889 | - |
dc.description.abstract | 1. The tissue level of lysophosphatidylcholine (LPC) was determined in rat hearts perfused with a solution containing 5 μM LPC. The relationship between LPC accumulation and the severity of arrhythmias produced was examined. 2. The accumulation of LPC was dependent on the perfusion time and this accumulation was associated with the occurrence of severe arrhythmias. A positive correlation between the tissue LPC content and the arrhythmia score was found (P < 0.01). 3. No consistent alteration in total phospholipid, phosphatidylcholine or cholesterol content was found. This suggests that LPC-induced arrhythmias are not associated with alterations of major lipid components in the heart. 4. When severe arrhythmias occurred in the presence of LPC in the rat perfused heart, less than 2% of total tissue phospholipid was in the form of LPC. 5. The positive correlation between LPC accumulation and the occurrence of arrhythmias suggests a cause and effect relationship of LPC with cardiac arrhythmias in the rat perfused heart. However, in the ischaemic heart, other biochemical factors can contribute, to different degrees, to ischaemia-induced cardiac arrhythmias. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 | en_US |
dc.relation.ispartof | British Journal of Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arrhythmias, Cardiac - Chemically Induced - Metabolism | en_US |
dc.subject.mesh | Body Water - Metabolism | en_US |
dc.subject.mesh | Cholesterol - Metabolism | en_US |
dc.subject.mesh | Heart - Drug Effects | en_US |
dc.subject.mesh | Lipid Metabolism | en_US |
dc.subject.mesh | Lysophosphatidylcholines - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Myocardium - Metabolism | en_US |
dc.subject.mesh | Phosphatidylcholines - Metabolism | en_US |
dc.subject.mesh | Phospholipids - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.title | Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1476-5381.1988.tb11448.x | - |
dc.identifier.pmid | 3359113 | - |
dc.identifier.scopus | eid_2-s2.0-0023850028 | en_US |
dc.identifier.volume | 93 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 412 | en_US |
dc.identifier.epage | 416 | en_US |
dc.identifier.isi | WOS:A1988M073500022 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0007-1188 | - |