File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart

TitleLysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart
Authors
Issue Date1988
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 1988, v. 93 n. 2, p. 412-416 How to Cite?
Abstract1. The tissue level of lysophosphatidylcholine (LPC) was determined in rat hearts perfused with a solution containing 5 μM LPC. The relationship between LPC accumulation and the severity of arrhythmias produced was examined. 2. The accumulation of LPC was dependent on the perfusion time and this accumulation was associated with the occurrence of severe arrhythmias. A positive correlation between the tissue LPC content and the arrhythmia score was found (P < 0.01). 3. No consistent alteration in total phospholipid, phosphatidylcholine or cholesterol content was found. This suggests that LPC-induced arrhythmias are not associated with alterations of major lipid components in the heart. 4. When severe arrhythmias occurred in the presence of LPC in the rat perfused heart, less than 2% of total tissue phospholipid was in the form of LPC. 5. The positive correlation between LPC accumulation and the occurrence of arrhythmias suggests a cause and effect relationship of LPC with cardiac arrhythmias in the rat perfused heart. However, in the ischaemic heart, other biochemical factors can contribute, to different degrees, to ischaemia-induced cardiac arrhythmias.
Persistent Identifierhttp://hdl.handle.net/10722/170889
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:18Z-
dc.date.available2012-10-30T06:11:18Z-
dc.date.issued1988en_US
dc.identifier.citationBritish Journal Of Pharmacology, 1988, v. 93 n. 2, p. 412-416en_US
dc.identifier.issn0007-1188en_US
dc.identifier.urihttp://hdl.handle.net/10722/170889-
dc.description.abstract1. The tissue level of lysophosphatidylcholine (LPC) was determined in rat hearts perfused with a solution containing 5 μM LPC. The relationship between LPC accumulation and the severity of arrhythmias produced was examined. 2. The accumulation of LPC was dependent on the perfusion time and this accumulation was associated with the occurrence of severe arrhythmias. A positive correlation between the tissue LPC content and the arrhythmia score was found (P < 0.01). 3. No consistent alteration in total phospholipid, phosphatidylcholine or cholesterol content was found. This suggests that LPC-induced arrhythmias are not associated with alterations of major lipid components in the heart. 4. When severe arrhythmias occurred in the presence of LPC in the rat perfused heart, less than 2% of total tissue phospholipid was in the form of LPC. 5. The positive correlation between LPC accumulation and the occurrence of arrhythmias suggests a cause and effect relationship of LPC with cardiac arrhythmias in the rat perfused heart. However, in the ischaemic heart, other biochemical factors can contribute, to different degrees, to ischaemia-induced cardiac arrhythmias.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Chemically Induced - Metabolismen_US
dc.subject.meshBody Water - Metabolismen_US
dc.subject.meshCholesterol - Metabolismen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshLipid Metabolismen_US
dc.subject.meshLysophosphatidylcholines - Metabolism - Pharmacologyen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshPhosphatidylcholines - Metabolismen_US
dc.subject.meshPhospholipids - Metabolismen_US
dc.subject.meshRatsen_US
dc.titleLysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1476-5381.1988.tb11448.x-
dc.identifier.pmid3359113-
dc.identifier.scopuseid_2-s2.0-0023850028en_US
dc.identifier.volume93en_US
dc.identifier.issue2en_US
dc.identifier.spage412en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:A1988M073500022-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats