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- Publisher Website: 10.1007/BF01952190
- Scopus: eid_2-s2.0-0023836716
- PMID: 3278917
- WOS: WOS:A1988M412300007
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Article: Platelets, endothelium and blood vessel wall
Title | Platelets, endothelium and blood vessel wall |
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Authors | |
Keywords | ADP ATP cod liver oil EDRF endothelium-dependent relaxations PAF regenerated endothelium serotonin thromboxane A2 vasopressin |
Issue Date | 1988 |
Publisher | Birkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm |
Citation | Experientia, 1988, v. 44 n. 2, p. 105-109 How to Cite? |
Abstract | Aggregating platelets cause contraction of vascular smooth muscle, because they release serotonin and thromboxane A2. If the platelets aggregate in a blood vessel with intact intima, the platelet-products cause endothelium-dependent relaxation of the underlying smooth muscle. Hence, the presence of an intact intima considerably reduces the vasospastic response to platelet-aggregation. The major platelet products which trigger endothelium-dependent relaxations are the adenine nucleotides and serotonin. The ability of the endothelium to prevent platelet-induced vasospasm is augmented after chronic intake of cod liver oil, but is reduced after previous intimal injury. |
Persistent Identifier | http://hdl.handle.net/10722/170886 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:16Z | - |
dc.date.available | 2012-10-30T06:11:16Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Experientia, 1988, v. 44 n. 2, p. 105-109 | en_US |
dc.identifier.issn | 0014-4754 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170886 | - |
dc.description.abstract | Aggregating platelets cause contraction of vascular smooth muscle, because they release serotonin and thromboxane A2. If the platelets aggregate in a blood vessel with intact intima, the platelet-products cause endothelium-dependent relaxation of the underlying smooth muscle. Hence, the presence of an intact intima considerably reduces the vasospastic response to platelet-aggregation. The major platelet products which trigger endothelium-dependent relaxations are the adenine nucleotides and serotonin. The ability of the endothelium to prevent platelet-induced vasospasm is augmented after chronic intake of cod liver oil, but is reduced after previous intimal injury. | en_US |
dc.language | eng | en_US |
dc.publisher | Birkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm | en_US |
dc.relation.ispartof | Experientia | en_US |
dc.subject | ADP | - |
dc.subject | ATP | - |
dc.subject | cod liver oil | - |
dc.subject | EDRF | - |
dc.subject | endothelium-dependent relaxations | - |
dc.subject | PAF | - |
dc.subject | regenerated endothelium | - |
dc.subject | serotonin | - |
dc.subject | thromboxane A2 | - |
dc.subject | vasopressin | - |
dc.subject.mesh | Adenine Nucleotides - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Physiology | en_US |
dc.subject.mesh | Blood Vessels - Physiology | en_US |
dc.subject.mesh | Coronary Vasospasm - Etiology | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Platelet Activating Factor - Physiology | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Thromboxanes - Physiology | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.title | Platelets, endothelium and blood vessel wall | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/BF01952190 | - |
dc.identifier.pmid | 3278917 | - |
dc.identifier.scopus | eid_2-s2.0-0023836716 | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 105 | en_US |
dc.identifier.epage | 109 | en_US |
dc.identifier.isi | WOS:A1988M412300007 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0014-4754 | - |