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Article: Platelets, endothelium and blood vessel wall

TitlePlatelets, endothelium and blood vessel wall
Authors
Issue Date1988
PublisherBirkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm
Citation
Experientia, 1988, v. 44 n. 2, p. 105-109 How to Cite?
AbstractAggregating platelets cause contraction of vascular smooth muscle, because they release serotonin and thromboxane A2. If the platelets aggregate in a blood vessel with intact intima, the platelet-products cause endothelium-dependent relaxation of the underlying smooth muscle. Hence, the presence of an intact intima considerably reduces the vasospastic response to platelet-aggregation. The major platelet products which trigger endothelium-dependent relaxations are the adenine nucleotides and serotonin. The ability of the endothelium to prevent platelet-induced vasospasm is augmented after chronic intake of cod liver oil, but is reduced after previous intimal injury.
Persistent Identifierhttp://hdl.handle.net/10722/170886
ISSN
1998 Impact Factor: 2.072
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:16Z-
dc.date.available2012-10-30T06:11:16Z-
dc.date.issued1988en_US
dc.identifier.citationExperientia, 1988, v. 44 n. 2, p. 105-109en_US
dc.identifier.issn0014-4754en_US
dc.identifier.urihttp://hdl.handle.net/10722/170886-
dc.description.abstractAggregating platelets cause contraction of vascular smooth muscle, because they release serotonin and thromboxane A2. If the platelets aggregate in a blood vessel with intact intima, the platelet-products cause endothelium-dependent relaxation of the underlying smooth muscle. Hence, the presence of an intact intima considerably reduces the vasospastic response to platelet-aggregation. The major platelet products which trigger endothelium-dependent relaxations are the adenine nucleotides and serotonin. The ability of the endothelium to prevent platelet-induced vasospasm is augmented after chronic intake of cod liver oil, but is reduced after previous intimal injury.en_US
dc.languageengen_US
dc.publisherBirkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htmen_US
dc.relation.ispartofExperientiaen_US
dc.subject.meshAdenine Nucleotides - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Platelets - Physiologyen_US
dc.subject.meshBlood Vessels - Physiologyen_US
dc.subject.meshCoronary Vasospasm - Etiologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshPlatelet Activating Factor - Physiologyen_US
dc.subject.meshPlatelet Aggregationen_US
dc.subject.meshThromboxanes - Physiologyen_US
dc.subject.meshVasoconstrictionen_US
dc.titlePlatelets, endothelium and blood vessel wallen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01952190-
dc.identifier.pmid3278917-
dc.identifier.scopuseid_2-s2.0-0023836716en_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.spage105en_US
dc.identifier.epage109en_US
dc.identifier.isiWOS:A1988M412300007-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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