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Article: Airway epithelium modulates the responsiveness of porcine bronchial smooth muscle

TitleAirway epithelium modulates the responsiveness of porcine bronchial smooth muscle
Authors
Issue Date1988
Citation
Journal Of Applied Physiology, 1988, v. 65 n. 2, p. 721-727 How to Cite?
AbstractThe effect of epithelium removal on the responses of porcine airways to exogenously applied agonists and nerve stimulation was examined. Paired rings of third- (segmental), fourth- and fifth-order (subsegmental) bronchi, with and without epithelium, were placed in organ chambers in physiological salt solution (95% O2-5% CO2, 37°C). Removal of the epithelium caused a leftward shift in the concentration-effect curve for acetylcholine (3rd and 4th order). A similar shift occurred for histamine (3rd and 5th order). The relaxation to isoproterenol was reduced by epithelium removal in a similar fashion in the three orders. Removal of the epithelium reduced the maximal response to KCl (3rd and 4th order) and acetylcholine (5th order). The peak response to nerve stimulation showed a significant rightward shift in the absence of epithelium. In fifth-order bronchi, tissues with epithelium showed a significantly greater degree of fade of the response to sustained electrical stimulation. Thus both epithelium-derived relaxing and contracting factors may be released in porcine airways.
Persistent Identifierhttp://hdl.handle.net/10722/170880
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStuartSmith, Ken_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:15Z-
dc.date.available2012-10-30T06:11:15Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Applied Physiology, 1988, v. 65 n. 2, p. 721-727en_US
dc.identifier.issn0161-7567en_US
dc.identifier.urihttp://hdl.handle.net/10722/170880-
dc.description.abstractThe effect of epithelium removal on the responses of porcine airways to exogenously applied agonists and nerve stimulation was examined. Paired rings of third- (segmental), fourth- and fifth-order (subsegmental) bronchi, with and without epithelium, were placed in organ chambers in physiological salt solution (95% O2-5% CO2, 37°C). Removal of the epithelium caused a leftward shift in the concentration-effect curve for acetylcholine (3rd and 4th order). A similar shift occurred for histamine (3rd and 5th order). The relaxation to isoproterenol was reduced by epithelium removal in a similar fashion in the three orders. Removal of the epithelium reduced the maximal response to KCl (3rd and 4th order) and acetylcholine (5th order). The peak response to nerve stimulation showed a significant rightward shift in the absence of epithelium. In fifth-order bronchi, tissues with epithelium showed a significantly greater degree of fade of the response to sustained electrical stimulation. Thus both epithelium-derived relaxing and contracting factors may be released in porcine airways.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchi - Drug Effects - Innervation - Physiologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshEpithelium - Physiologyen_US
dc.subject.meshHistamine - Pharmacologyen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth - Innervation - Physiologyen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshPropranolol - Pharmacologyen_US
dc.subject.meshSwine - Physiologyen_US
dc.titleAirway epithelium modulates the responsiveness of porcine bronchial smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3170426-
dc.identifier.scopuseid_2-s2.0-0023767051en_US
dc.identifier.volume65en_US
dc.identifier.issue2en_US
dc.identifier.spage721en_US
dc.identifier.epage727en_US
dc.identifier.isiWOS:A1988P709300030-
dc.identifier.scopusauthoridStuartSmith, K=6701396133en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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