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- Publisher Website: 10.1172/JCI113212
- Scopus: eid_2-s2.0-0023608139
- PMID: 2890656
- WOS: WOS:A1987K669200018
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Article: Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog
Title | Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog |
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Authors | |
Issue Date | 1987 |
Publisher | American Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org |
Citation | Journal Of Clinical Investigation, 1987, v. 80 n. 5, p. 1350-1357 How to Cite? |
Abstract | Endothelium-dependent responses differ in arteries and veins of the dog. Experiments were performed to determine whether chronic grafting of veins into the arterial circulation would alter the endothelium-dependent responses of the veins. Segments of femoral veins were grafted to the femoral artery of the dog. 6 wk after surgery the venous grafts were removed from the dog, cut into rings, and suspended in organ chambers for isometric tension recording. In some rings the endothelial cells were removed. Acetylcholine and α2-adrenergic agonists did not cause endothelium-dependent relaxations in venous grafts. The calcium ionophore (A23187) initiated such relaxations which were not mediated by prostanoids. Endothelium-dependent relaxations were also observed in venous grafts to ADP, thrombin, and arachidonic acid. In segments of graft where myo-intimal hyperplasia was prominent, relaxations to ADP, thrombin, and A23187 were blunted and in some segments contractions were observed. These results demonstrate the ability of the endothelium of venous grafts to initiate changes in tone of the smooth muscle. |
Persistent Identifier | http://hdl.handle.net/10722/170862 |
ISSN | 2023 Impact Factor: 13.3 2023 SCImago Journal Rankings: 4.833 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Miller, VM | en_US |
dc.contributor.author | Reigel, MM | en_US |
dc.contributor.author | Hollier, LH | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:10Z | - |
dc.date.available | 2012-10-30T06:11:10Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Journal Of Clinical Investigation, 1987, v. 80 n. 5, p. 1350-1357 | en_US |
dc.identifier.issn | 0021-9738 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170862 | - |
dc.description.abstract | Endothelium-dependent responses differ in arteries and veins of the dog. Experiments were performed to determine whether chronic grafting of veins into the arterial circulation would alter the endothelium-dependent responses of the veins. Segments of femoral veins were grafted to the femoral artery of the dog. 6 wk after surgery the venous grafts were removed from the dog, cut into rings, and suspended in organ chambers for isometric tension recording. In some rings the endothelial cells were removed. Acetylcholine and α2-adrenergic agonists did not cause endothelium-dependent relaxations in venous grafts. The calcium ionophore (A23187) initiated such relaxations which were not mediated by prostanoids. Endothelium-dependent relaxations were also observed in venous grafts to ADP, thrombin, and arachidonic acid. In segments of graft where myo-intimal hyperplasia was prominent, relaxations to ADP, thrombin, and A23187 were blunted and in some segments contractions were observed. These results demonstrate the ability of the endothelium of venous grafts to initiate changes in tone of the smooth muscle. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org | en_US |
dc.relation.ispartof | Journal of Clinical Investigation | en_US |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Adrenergic Alpha-Agonists - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arachidonic Acid | en_US |
dc.subject.mesh | Arachidonic Acids - Pharmacology | en_US |
dc.subject.mesh | Arteries | en_US |
dc.subject.mesh | Calcimycin - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Femoral Vein - Physiology - Transplantation | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiology | en_US |
dc.subject.mesh | Quinoxalines - Pharmacology | en_US |
dc.subject.mesh | Thrombin - Pharmacology | en_US |
dc.title | Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1172/JCI113212 | - |
dc.identifier.pmid | 2890656 | - |
dc.identifier.scopus | eid_2-s2.0-0023608139 | en_US |
dc.identifier.volume | 80 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 1350 | en_US |
dc.identifier.epage | 1357 | en_US |
dc.identifier.isi | WOS:A1987K669200018 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Miller, VM=7201476816 | en_US |
dc.identifier.scopusauthorid | Reigel, MM=6506723082 | en_US |
dc.identifier.scopusauthorid | Hollier, LH=35420266500 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0021-9738 | - |