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Article: Heterogeneity in the effects of epithelium removal in the canine bronchial tree

TitleHeterogeneity in the effects of epithelium removal in the canine bronchial tree
Authors
Issue Date1987
Citation
Journal Of Applied Physiology, 1987, v. 63 n. 6, p. 2510-2515 How to Cite?
AbstractThe effect of removing the airway epithelium on the responses of canine airways of decreasing diameter to contractile and relaxing agonists was explored. Three orders of canine bronchus were studied: second order (lobar bronchus), third order (segmental bronchus), and fourth order (subsegmental bronchus). Paired rings of tissue, with and without epithelium, were placed in organ chambers in physiological salt solution gassed with 95% O2-5% CO2 and maintained at 37°C. For second- and third-order bronchi, epithelium removal caused significant leftward shifts of the concentration-effect curves for 5-hydroxytryptamine, histamine, and acetylcholine. In fourth-order bronchi, there was no significant shift for any of the contractile agonists. Isoproterenol (during contractions evoked by acetylcholine) induced concentration-dependent relaxations that were significantly greater in bronchi with than in those without epithelium. This effect was most prominent in fourth-order bronchi. These results suggest that 1) the canine airway epithelium releases a relaxing factor, 2) in larger airways the major effect is reduction of contractile responses, and 3) in smaller airways the major effect is enhancement of relaxing responses.
Persistent Identifierhttp://hdl.handle.net/10722/170858
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStuartSmith, Ken_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:08Z-
dc.date.available2012-10-30T06:11:08Z-
dc.date.issued1987en_US
dc.identifier.citationJournal Of Applied Physiology, 1987, v. 63 n. 6, p. 2510-2515en_US
dc.identifier.issn0161-7567en_US
dc.identifier.urihttp://hdl.handle.net/10722/170858-
dc.description.abstractThe effect of removing the airway epithelium on the responses of canine airways of decreasing diameter to contractile and relaxing agonists was explored. Three orders of canine bronchus were studied: second order (lobar bronchus), third order (segmental bronchus), and fourth order (subsegmental bronchus). Paired rings of tissue, with and without epithelium, were placed in organ chambers in physiological salt solution gassed with 95% O2-5% CO2 and maintained at 37°C. For second- and third-order bronchi, epithelium removal caused significant leftward shifts of the concentration-effect curves for 5-hydroxytryptamine, histamine, and acetylcholine. In fourth-order bronchi, there was no significant shift for any of the contractile agonists. Isoproterenol (during contractions evoked by acetylcholine) induced concentration-dependent relaxations that were significantly greater in bronchi with than in those without epithelium. This effect was most prominent in fourth-order bronchi. These results suggest that 1) the canine airway epithelium releases a relaxing factor, 2) in larger airways the major effect is reduction of contractile responses, and 3) in smaller airways the major effect is enhancement of relaxing responses.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchi - Drug Effects - Physiology - Surgeryen_US
dc.subject.meshDogsen_US
dc.subject.meshEpithelium - Physiologyen_US
dc.subject.meshHistamine - Pharmacologyen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.titleHeterogeneity in the effects of epithelium removal in the canine bronchial treeen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3436881-
dc.identifier.scopuseid_2-s2.0-0023553322en_US
dc.identifier.volume63en_US
dc.identifier.issue6en_US
dc.identifier.spage2510en_US
dc.identifier.epage2515en_US
dc.identifier.isiWOS:A1987L459900045-
dc.identifier.scopusauthoridStuartSmith, K=6701396133en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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