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Article: Flunarizine and α-adrenergic responses in isolated canine saphenous veins

TitleFlunarizine and α-adrenergic responses in isolated canine saphenous veins
Authors
Issue Date1987
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology: Vascular System, 1987, v. 18 n. 2, p. 193-196 How to Cite?
Abstract1. Experiments were designed to determine how flunarizine affects contractions of cutaneous veins to α-adrenergic activation. 2. Rings of canine saphenous vein were mounted at optimal length for isometric tension recording in organ chambers filled with physiological salt solution. 3. At concentrations higher than those needed to inhibit KCl-induced contractions, flunarizine inhibited the contractile responses evoked by α2-adrenergic agonists (B-HT 920, xylazine), partial (St-587) and full (cirazoline, phenylephrine) α1-adrenergic agonists and the combined α1-/α2-adrenergic agonist, norepinephrine. 4. The inhibitory effect of flunarizine against α2-adrenergic responses was similar to that produced by other calcium-antagonists and results presumably from inhibition of the influx of extracellular calcium. 5. The inhibitory effect of flunarizine against α1-adrenergic responses was greater than expected and appears to result from competitive antagonism of α1-adrenoceptors (pA2 = 5.79). 6. Therefore, flunarizine can decrease adrenergic contractile responses by depressing the influx of extracellular calcium and by blocking postjunctional α1-adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/170840
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDaskalopoulos, DAen_US
dc.contributor.authorRimele, TJen_US
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:04Z-
dc.date.available2012-10-30T06:11:04Z-
dc.date.issued1987en_US
dc.identifier.citationGeneral Pharmacology: Vascular System, 1987, v. 18 n. 2, p. 193-196en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/170840-
dc.description.abstract1. Experiments were designed to determine how flunarizine affects contractions of cutaneous veins to α-adrenergic activation. 2. Rings of canine saphenous vein were mounted at optimal length for isometric tension recording in organ chambers filled with physiological salt solution. 3. At concentrations higher than those needed to inhibit KCl-induced contractions, flunarizine inhibited the contractile responses evoked by α2-adrenergic agonists (B-HT 920, xylazine), partial (St-587) and full (cirazoline, phenylephrine) α1-adrenergic agonists and the combined α1-/α2-adrenergic agonist, norepinephrine. 4. The inhibitory effect of flunarizine against α2-adrenergic responses was similar to that produced by other calcium-antagonists and results presumably from inhibition of the influx of extracellular calcium. 5. The inhibitory effect of flunarizine against α1-adrenergic responses was greater than expected and appears to result from competitive antagonism of α1-adrenoceptors (pA2 = 5.79). 6. Therefore, flunarizine can decrease adrenergic contractile responses by depressing the influx of extracellular calcium and by blocking postjunctional α1-adrenoceptors.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacology: Vascular Systemen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlunarizine - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effects - Physiologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Physiologyen_US
dc.titleFlunarizine and α-adrenergic responses in isolated canine saphenous veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(87)90249-7-
dc.identifier.pmid2883070-
dc.identifier.scopuseid_2-s2.0-0023136806en_US
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.spage193en_US
dc.identifier.epage196en_US
dc.identifier.isiWOS:A1987G614900015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDaskalopoulos, DA=7801377476en_US
dc.identifier.scopusauthoridRimele, TJ=7004614618en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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