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Article: Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats

TitleEndothelium-dependent vascular responses in normotensive and hypertensive Dahl rats
Authors
Issue Date1987
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 1987, v. 9 n. 2, p. 157-163 How to Cite?
AbstractExperiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood pressure in DS fed a high sodium diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. Acetylcholine, adenosine 5'-diphosphate, and thrombin induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high sodium diet. The relaxations in response to sodium nitroprusside were only slightly, but significantly, depressed in DS fed a high sodium diet. Removal of the endothelium greatly enhanced the response to serotonin and norepinephrine. In rings with, but not without, endothelium taken from rats fed a high sodium diet, the tension developed in response to serotonin and norepinephrine was significantly greater than that in animals fed a low sodium diet. These experiments indicate that (1) endothelium-dependent relaxations to acetylcholine, adenosine 5'-diphosphate, and thrombin are depressed in hypertensive Dahl rats; (2) this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and (3) the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high sodium diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function.
Persistent Identifierhttp://hdl.handle.net/10722/170838
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuscher, TFen_US
dc.contributor.authorRaij, Len_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:03Z-
dc.date.available2012-10-30T06:11:03Z-
dc.date.issued1987en_US
dc.identifier.citationHypertension, 1987, v. 9 n. 2, p. 157-163en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170838-
dc.description.abstractExperiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood pressure in DS fed a high sodium diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. Acetylcholine, adenosine 5'-diphosphate, and thrombin induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high sodium diet. The relaxations in response to sodium nitroprusside were only slightly, but significantly, depressed in DS fed a high sodium diet. Removal of the endothelium greatly enhanced the response to serotonin and norepinephrine. In rings with, but not without, endothelium taken from rats fed a high sodium diet, the tension developed in response to serotonin and norepinephrine was significantly greater than that in animals fed a low sodium diet. These experiments indicate that (1) endothelium-dependent relaxations to acetylcholine, adenosine 5'-diphosphate, and thrombin are depressed in hypertensive Dahl rats; (2) this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and (3) the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high sodium diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAdenosine Diphosphate - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndothelium - Physiopathologyen_US
dc.subject.meshHypertension - Chemically Induced - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiopathologyen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshSodium Chloride - Administration & Dosageen_US
dc.subject.meshThrombin - Pharmacologyen_US
dc.subject.meshVasoconstrictor Agents - Pharmacologyen_US
dc.titleEndothelium-dependent vascular responses in normotensive and hypertensive Dahl ratsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.HYP.9.2.157-
dc.identifier.pmid3818012-
dc.identifier.scopuseid_2-s2.0-0023113462en_US
dc.identifier.volume9en_US
dc.identifier.issue2en_US
dc.identifier.spage157en_US
dc.identifier.epage163en_US
dc.identifier.isiWOS:A1987G053600007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuscher, TF=18935805600en_US
dc.identifier.scopusauthoridRaij, L=7006228846en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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