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- Publisher Website: 10.1161/01.HYP.9.2.157
- Scopus: eid_2-s2.0-0023113462
- PMID: 3818012
- WOS: WOS:A1987G053600007
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Article: Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats
Title | Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats |
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Authors | |
Issue Date | 1987 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 1987, v. 9 n. 2, p. 157-163 How to Cite? |
Abstract | Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood pressure in DS fed a high sodium diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. Acetylcholine, adenosine 5'-diphosphate, and thrombin induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high sodium diet. The relaxations in response to sodium nitroprusside were only slightly, but significantly, depressed in DS fed a high sodium diet. Removal of the endothelium greatly enhanced the response to serotonin and norepinephrine. In rings with, but not without, endothelium taken from rats fed a high sodium diet, the tension developed in response to serotonin and norepinephrine was significantly greater than that in animals fed a low sodium diet. These experiments indicate that (1) endothelium-dependent relaxations to acetylcholine, adenosine 5'-diphosphate, and thrombin are depressed in hypertensive Dahl rats; (2) this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and (3) the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high sodium diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function. |
Persistent Identifier | http://hdl.handle.net/10722/170838 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.827 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Luscher, TF | en_US |
dc.contributor.author | Raij, L | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:03Z | - |
dc.date.available | 2012-10-30T06:11:03Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Hypertension, 1987, v. 9 n. 2, p. 157-163 | en_US |
dc.identifier.issn | 0194-911X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170838 | - |
dc.description.abstract | Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood pressure in DS fed a high sodium diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. Acetylcholine, adenosine 5'-diphosphate, and thrombin induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high sodium diet. The relaxations in response to sodium nitroprusside were only slightly, but significantly, depressed in DS fed a high sodium diet. Removal of the endothelium greatly enhanced the response to serotonin and norepinephrine. In rings with, but not without, endothelium taken from rats fed a high sodium diet, the tension developed in response to serotonin and norepinephrine was significantly greater than that in animals fed a low sodium diet. These experiments indicate that (1) endothelium-dependent relaxations to acetylcholine, adenosine 5'-diphosphate, and thrombin are depressed in hypertensive Dahl rats; (2) this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and (3) the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high sodium diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | en_US |
dc.relation.ispartof | Hypertension | en_US |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Endothelium - Physiopathology | en_US |
dc.subject.mesh | Hypertension - Chemically Induced - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiopathology | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Sodium Chloride - Administration & Dosage | en_US |
dc.subject.mesh | Thrombin - Pharmacology | en_US |
dc.subject.mesh | Vasoconstrictor Agents - Pharmacology | en_US |
dc.title | Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.HYP.9.2.157 | - |
dc.identifier.pmid | 3818012 | - |
dc.identifier.scopus | eid_2-s2.0-0023113462 | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 157 | en_US |
dc.identifier.epage | 163 | en_US |
dc.identifier.isi | WOS:A1987G053600007 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Luscher, TF=18935805600 | en_US |
dc.identifier.scopusauthorid | Raij, L=7006228846 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0194-911X | - |