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- Publisher Website: 10.1016/0014-2999(86)90477-2
- Scopus: eid_2-s2.0-0022632857
- PMID: 3948924
- WOS: WOS:A1986A339200013
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Article: Verapamil worsens ethanol-induced gastric ulcers in rats
Title | Verapamil worsens ethanol-induced gastric ulcers in rats |
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Authors | |
Keywords | Calcium Ethanol Gastric ulcers Verapamil |
Issue Date | 1986 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1986, v. 120 n. 3, p. 355-358 How to Cite? |
Abstract | The effect of verapamil on ethanol-induced gastric ulceration was investigated in rats. Orally administered ethanol (0.5 ml), 10, 20 or 40% v/v, dose dependently produced glandular lesions, ranging from petechiae to haemorrhagic ulcers. These lesions were worsened by verapamil (2,4 or 8 mg/kg given intraperitoneally (i.p.) 30 min beforehand) in the 30 min and 2 h ethanol-exposure experiments. However, ethanol ulceration or its aggravation by verapamil was antagonized by calcium gluconate (112 or 224 mg/kg given per os (p.o.) 30 min before ethanol administration) in a dose-related manner. These findings suggest that intracellular calcium depletion in the gastric glandular mucosa may account for ethanol ulceration and the ulcer-aggravating action of verapamil. |
Persistent Identifier | http://hdl.handle.net/10722/170822 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, MWL | en_US |
dc.contributor.author | Cho, CH | en_US |
dc.contributor.author | Ogle, CW | en_US |
dc.date.accessioned | 2012-10-30T06:11:00Z | - |
dc.date.available | 2012-10-30T06:11:00Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1986, v. 120 n. 3, p. 355-358 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170822 | - |
dc.description.abstract | The effect of verapamil on ethanol-induced gastric ulceration was investigated in rats. Orally administered ethanol (0.5 ml), 10, 20 or 40% v/v, dose dependently produced glandular lesions, ranging from petechiae to haemorrhagic ulcers. These lesions were worsened by verapamil (2,4 or 8 mg/kg given intraperitoneally (i.p.) 30 min beforehand) in the 30 min and 2 h ethanol-exposure experiments. However, ethanol ulceration or its aggravation by verapamil was antagonized by calcium gluconate (112 or 224 mg/kg given per os (p.o.) 30 min before ethanol administration) in a dose-related manner. These findings suggest that intracellular calcium depletion in the gastric glandular mucosa may account for ethanol ulceration and the ulcer-aggravating action of verapamil. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Calcium | - |
dc.subject | Ethanol | - |
dc.subject | Gastric ulcers | - |
dc.subject | Verapamil | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcium Gluconate - Pharmacology | en_US |
dc.subject.mesh | Drug Synergism | en_US |
dc.subject.mesh | Ethanol - Toxicity | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Stomach Ulcer - Chemically Induced | en_US |
dc.subject.mesh | Verapamil - Toxicity | en_US |
dc.title | Verapamil worsens ethanol-induced gastric ulcers in rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Koo, MWL:wlkoo@hku.hk | en_US |
dc.identifier.authority | Koo, MWL=rp00233 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-2999(86)90477-2 | - |
dc.identifier.pmid | 3948924 | - |
dc.identifier.scopus | eid_2-s2.0-0022632857 | en_US |
dc.identifier.volume | 120 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 355 | en_US |
dc.identifier.epage | 358 | en_US |
dc.identifier.isi | WOS:A1986A339200013 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Koo, MWL=7004550899 | en_US |
dc.identifier.scopusauthorid | Cho, CH=7403100461 | en_US |
dc.identifier.scopusauthorid | Ogle, CW=7103150233 | en_US |
dc.identifier.issnl | 0014-2999 | - |