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Article: Verapamil worsens ethanol-induced gastric ulcers in rats

TitleVerapamil worsens ethanol-induced gastric ulcers in rats
Authors
Issue Date1986
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1986, v. 120 n. 3, p. 355-358 How to Cite?
AbstractThe effect of verapamil on ethanol-induced gastric ulceration was investigated in rats. Orally administered ethanol (0.5 ml), 10, 20 or 40% v/v, dose dependently produced glandular lesions, ranging from petechiae to haemorrhagic ulcers. These lesions were worsened by verapamil (2,4 or 8 mg/kg given intraperitoneally (i.p.) 30 min beforehand) in the 30 min and 2 h ethanol-exposure experiments. However, ethanol ulceration or its aggravation by verapamil was antagonized by calcium gluconate (112 or 224 mg/kg given per os (p.o.) 30 min before ethanol administration) in a dose-related manner. These findings suggest that intracellular calcium depletion in the gastric glandular mucosa may account for ethanol ulceration and the ulcer-aggravating action of verapamil.
Persistent Identifierhttp://hdl.handle.net/10722/170822
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorOgle, CWen_US
dc.date.accessioned2012-10-30T06:11:00Z-
dc.date.available2012-10-30T06:11:00Z-
dc.date.issued1986en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1986, v. 120 n. 3, p. 355-358en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170822-
dc.description.abstractThe effect of verapamil on ethanol-induced gastric ulceration was investigated in rats. Orally administered ethanol (0.5 ml), 10, 20 or 40% v/v, dose dependently produced glandular lesions, ranging from petechiae to haemorrhagic ulcers. These lesions were worsened by verapamil (2,4 or 8 mg/kg given intraperitoneally (i.p.) 30 min beforehand) in the 30 min and 2 h ethanol-exposure experiments. However, ethanol ulceration or its aggravation by verapamil was antagonized by calcium gluconate (112 or 224 mg/kg given per os (p.o.) 30 min before ethanol administration) in a dose-related manner. These findings suggest that intracellular calcium depletion in the gastric glandular mucosa may account for ethanol ulceration and the ulcer-aggravating action of verapamil.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Gluconate - Pharmacologyen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshEthanol - Toxicityen_US
dc.subject.meshFemaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshStomach Ulcer - Chemically Induceden_US
dc.subject.meshVerapamil - Toxicityen_US
dc.titleVerapamil worsens ethanol-induced gastric ulcers in ratsen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(86)90477-2-
dc.identifier.pmid3948924-
dc.identifier.scopuseid_2-s2.0-0022632857en_US
dc.identifier.volume120en_US
dc.identifier.issue3en_US
dc.identifier.spage355en_US
dc.identifier.epage358en_US
dc.identifier.isiWOS:A1986A339200013-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US

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