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Article: Effects of temperature on α adrenoceptors in limb veins: Role of receptor reserve

TitleEffects of temperature on α adrenoceptors in limb veins: Role of receptor reserve
Authors
Issue Date1986
Citation
Federation Proceedings, 1986, v. 45 n. 9, p. 2347-2354 How to Cite?
AbstractIn cutaneous veins of the dog, cooling augments the response to sympathetic nerve stimulation and exogenous norepinephrine (NE). The postjunctional α adrenoceptors in this blood vessel belong to both the α1 and α2 subtypes. Cooling augments α2-adrenergic responses (presumably because of an increased receptor affinity), but depresses α1-adrenergic responses (presumably because of a direct inhibitory effect on the contractile process). When agonists of high efficacy such as NE or phenylephrine are used, an α1 adrenoceptor reserve is present that buffers the response from the inhibitory effect of cooling. This allows the potentiating effect of cold on the α2-adrenergic component of the response to catecholamines to predominate, and the contractile response to exogenous NE and sympathetic nerve stimulation is augmented. By contrast, in deep veins of the limb, cold reduces the contractions evoked by α1- and α2-adrenergic activation. This can be explained best by the absence of a receptor reserve for α1-adrenergic agonists of high efficacy, combined with a reduced density of postjunctional α2 adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/170808
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorFlavahan, NAen_US
dc.date.accessioned2012-10-30T06:10:57Z-
dc.date.available2012-10-30T06:10:57Z-
dc.date.issued1986en_US
dc.identifier.citationFederation Proceedings, 1986, v. 45 n. 9, p. 2347-2354en_US
dc.identifier.issn0014-9446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170808-
dc.description.abstractIn cutaneous veins of the dog, cooling augments the response to sympathetic nerve stimulation and exogenous norepinephrine (NE). The postjunctional α adrenoceptors in this blood vessel belong to both the α1 and α2 subtypes. Cooling augments α2-adrenergic responses (presumably because of an increased receptor affinity), but depresses α1-adrenergic responses (presumably because of a direct inhibitory effect on the contractile process). When agonists of high efficacy such as NE or phenylephrine are used, an α1 adrenoceptor reserve is present that buffers the response from the inhibitory effect of cooling. This allows the potentiating effect of cold on the α2-adrenergic component of the response to catecholamines to predominate, and the contractile response to exogenous NE and sympathetic nerve stimulation is augmented. By contrast, in deep veins of the limb, cold reduces the contractions evoked by α1- and α2-adrenergic activation. This can be explained best by the absence of a receptor reserve for α1-adrenergic agonists of high efficacy, combined with a reduced density of postjunctional α2 adrenoceptors.en_US
dc.languageengen_US
dc.relation.ispartofFederation Proceedingsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDogsen_US
dc.subject.meshExtremities - Blood Supplyen_US
dc.subject.meshFemoral Vein - Innervationen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenoxybenzamine - Pharmacologyen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Analysis - Drug Effects - Physiologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Innervationen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleEffects of temperature on α adrenoceptors in limb veins: Role of receptor reserveen_US
dc.typeArticleen_US
dc.identifier.emailVanHoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanHoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3015688-
dc.identifier.scopuseid_2-s2.0-0022458269en_US
dc.identifier.volume45en_US
dc.identifier.issue9en_US
dc.identifier.spage2347en_US
dc.identifier.epage2354en_US
dc.identifier.isiWOS:A1986D483400012-
dc.identifier.scopusauthoridVanHoutte, PM=7202304247en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US

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