File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Endothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels

TitleEndothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels
Authors
Issue Date1985
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1985, v. 118 n. 1-2, p. 123-129 How to Cite?
AbstractThe present study was designed to determine whether α2-adrenoceptors mediate endothelium-dependent relaxations in veins and arteries of the pulmonary and systemic vasculature of the dog. Rings of either pulmonary or femoral artery and vein with and without endothelium were suspended for isometric force measurements in a buffered salt solution (37°C; gassed with 95% O2 and 5% CO2). Removal of the endothelium caused a shift to the left of the concentration-response curves to epinephrine, norepinephrine and the selective α2-adrenoceptor agonist UK 14,304, but not of that to the selective α1-adrenoceptor agonist phenylephrine. In the presence of α1- and β-adrenoceptor blockers, norepinephrine and UK 14,304 initiated relaxations of previously contracted rings. These relaxations were inhibited by the α2-adrenoceptor antagonist, rauwolscine, and were absent in rings without endothelium. In the pulmonary artery and femoral vein, the endothelium-dependent responses to UK 14,304 were masked in part by direct α2-adrenergic activation of the vascular smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170793
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMiller, VMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:52Z-
dc.date.available2012-10-30T06:10:52Z-
dc.date.issued1985en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1985, v. 118 n. 1-2, p. 123-129en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170793-
dc.description.abstractThe present study was designed to determine whether α2-adrenoceptors mediate endothelium-dependent relaxations in veins and arteries of the pulmonary and systemic vasculature of the dog. Rings of either pulmonary or femoral artery and vein with and without endothelium were suspended for isometric force measurements in a buffered salt solution (37°C; gassed with 95% O2 and 5% CO2). Removal of the endothelium caused a shift to the left of the concentration-response curves to epinephrine, norepinephrine and the selective α2-adrenoceptor agonist UK 14,304, but not of that to the selective α1-adrenoceptor agonist phenylephrine. In the presence of α1- and β-adrenoceptor blockers, norepinephrine and UK 14,304 initiated relaxations of previously contracted rings. These relaxations were inhibited by the α2-adrenoceptor antagonist, rauwolscine, and were absent in rings without endothelium. In the pulmonary artery and femoral vein, the endothelium-dependent responses to UK 14,304 were masked in part by direct α2-adrenergic activation of the vascular smooth muscle.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntihypertensive Agents - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshIsometric Contraction - Drug Effectsen_US
dc.subject.meshLung - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Metabolismen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshPulmonary Artery - Drug Effectsen_US
dc.subject.meshPulmonary Veins - Drug Effectsen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Metabolismen_US
dc.titleEndothelial α2-adrenoceptors in canine pulmonary and systemic blood vesselsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(85)90670-3-
dc.identifier.pmid3002807-
dc.identifier.scopuseid_2-s2.0-0022342569en_US
dc.identifier.volume118en_US
dc.identifier.issue1-2en_US
dc.identifier.spage123en_US
dc.identifier.epage129en_US
dc.identifier.isiWOS:A1985AXT2900014-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridMiller, VM=7201476816en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats