File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0014-2999(85)90670-3
- Scopus: eid_2-s2.0-0022342569
- PMID: 3002807
- WOS: WOS:A1985AXT2900014
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Endothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels
Title | Endothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels |
---|---|
Authors | |
Keywords | Catecholamines Endothelium-dependent responses Epinephrine Femoral artery Fermoral vein Norepinephrine Phenylephrine Pulmonary artery Pulmonary vein Rauwolscine UK 14,304 α-Adrenoceptor |
Issue Date | 1985 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1985, v. 118 n. 1-2, p. 123-129 How to Cite? |
Abstract | The present study was designed to determine whether α2-adrenoceptors mediate endothelium-dependent relaxations in veins and arteries of the pulmonary and systemic vasculature of the dog. Rings of either pulmonary or femoral artery and vein with and without endothelium were suspended for isometric force measurements in a buffered salt solution (37°C; gassed with 95% O2 and 5% CO2). Removal of the endothelium caused a shift to the left of the concentration-response curves to epinephrine, norepinephrine and the selective α2-adrenoceptor agonist UK 14,304, but not of that to the selective α1-adrenoceptor agonist phenylephrine. In the presence of α1- and β-adrenoceptor blockers, norepinephrine and UK 14,304 initiated relaxations of previously contracted rings. These relaxations were inhibited by the α2-adrenoceptor antagonist, rauwolscine, and were absent in rings without endothelium. In the pulmonary artery and femoral vein, the endothelium-dependent responses to UK 14,304 were masked in part by direct α2-adrenergic activation of the vascular smooth muscle. |
Persistent Identifier | http://hdl.handle.net/10722/170793 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Miller, VM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:52Z | - |
dc.date.available | 2012-10-30T06:10:52Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1985, v. 118 n. 1-2, p. 123-129 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170793 | - |
dc.description.abstract | The present study was designed to determine whether α2-adrenoceptors mediate endothelium-dependent relaxations in veins and arteries of the pulmonary and systemic vasculature of the dog. Rings of either pulmonary or femoral artery and vein with and without endothelium were suspended for isometric force measurements in a buffered salt solution (37°C; gassed with 95% O2 and 5% CO2). Removal of the endothelium caused a shift to the left of the concentration-response curves to epinephrine, norepinephrine and the selective α2-adrenoceptor agonist UK 14,304, but not of that to the selective α1-adrenoceptor agonist phenylephrine. In the presence of α1- and β-adrenoceptor blockers, norepinephrine and UK 14,304 initiated relaxations of previously contracted rings. These relaxations were inhibited by the α2-adrenoceptor antagonist, rauwolscine, and were absent in rings without endothelium. In the pulmonary artery and femoral vein, the endothelium-dependent responses to UK 14,304 were masked in part by direct α2-adrenergic activation of the vascular smooth muscle. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Catecholamines | - |
dc.subject | Endothelium-dependent responses | - |
dc.subject | Epinephrine | - |
dc.subject | Femoral artery | - |
dc.subject | Fermoral vein | - |
dc.subject | Norepinephrine | - |
dc.subject | Phenylephrine | - |
dc.subject | Pulmonary artery | - |
dc.subject | Pulmonary vein | - |
dc.subject | Rauwolscine | - |
dc.subject | UK 14,304 | - |
dc.subject | α-Adrenoceptor | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antihypertensive Agents - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium - Metabolism | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Isometric Contraction - Drug Effects | en_US |
dc.subject.mesh | Lung - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Metabolism | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Phenylephrine - Pharmacology | en_US |
dc.subject.mesh | Pulmonary Artery - Drug Effects | en_US |
dc.subject.mesh | Pulmonary Veins - Drug Effects | en_US |
dc.subject.mesh | Quinoxalines - Pharmacology | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Metabolism | en_US |
dc.title | Endothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-2999(85)90670-3 | - |
dc.identifier.pmid | 3002807 | - |
dc.identifier.scopus | eid_2-s2.0-0022342569 | en_US |
dc.identifier.volume | 118 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 123 | en_US |
dc.identifier.epage | 129 | en_US |
dc.identifier.isi | WOS:A1985AXT2900014 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Miller, VM=7201476816 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0014-2999 | - |