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Article: The respiratory epithelium releases a smooth muscle relaxing factor

TitleThe respiratory epithelium releases a smooth muscle relaxing factor
Authors
Issue Date1985
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 1985, v. 87 n. 5 SUPPL., p. 189S-190S How to Cite?
AbstractDysfunction of respiratory epithelial cells may contribute to the pathogenesis of bronchial hyperreactivity in asthma. The aim of this study was to determine whether the respiratory epithelium can modulate directly the responsiveness of bronchial smooth muscle. The results indicate that the respiratory epithelium releases a smooth muscle relaxing factor to inhibit the effects of bronchoconstrictor agonists and to augment the direct inhibitory effects of relaxing stimuli. Moreover, the influence of epithelium removal on the responses to nerve stimulation suggests that this inhibitory factor might be released following activation of the epithelium by these agonists. For example, the delay in the epithelium-dependent inhibitory response during nerve stimulation might represent the diffusion of nerve-released acetylcholine to the epithelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/170790
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176

 

DC FieldValueLanguage
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:52Z-
dc.date.available2012-10-30T06:10:52Z-
dc.date.issued1985en_US
dc.identifier.citationChest, 1985, v. 87 n. 5 SUPPL., p. 189S-190Sen_US
dc.identifier.issn0012-3692en_US
dc.identifier.urihttp://hdl.handle.net/10722/170790-
dc.description.abstractDysfunction of respiratory epithelial cells may contribute to the pathogenesis of bronchial hyperreactivity in asthma. The aim of this study was to determine whether the respiratory epithelium can modulate directly the responsiveness of bronchial smooth muscle. The results indicate that the respiratory epithelium releases a smooth muscle relaxing factor to inhibit the effects of bronchoconstrictor agonists and to augment the direct inhibitory effects of relaxing stimuli. Moreover, the influence of epithelium removal on the responses to nerve stimulation suggests that this inhibitory factor might be released following activation of the epithelium by these agonists. For example, the delay in the epithelium-dependent inhibitory response during nerve stimulation might represent the diffusion of nerve-released acetylcholine to the epithelial cells.en_US
dc.languageengen_US
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_US
dc.relation.ispartofChesten_US
dc.titleThe respiratory epithelium releases a smooth muscle relaxing factoren_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0022254341en_US
dc.identifier.volume87en_US
dc.identifier.issue5 SUPPL.en_US
dc.identifier.spage189Sen_US
dc.identifier.epage190Sen_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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