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Article: Lipoxygenase and calcium entry in vascular smooth muscle

TitleLipoxygenase and calcium entry in vascular smooth muscle
Authors
Issue Date1985
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 6, p. S47-S52 How to Cite?
AbstractIn the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine, potassium chloride and partial α-adrenergic activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, end-products of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries.
Persistent Identifierhttp://hdl.handle.net/10722/170789
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorRimele, TJen_US
dc.contributor.authorFlavahan, NAen_US
dc.date.accessioned2012-10-30T06:10:52Z-
dc.date.available2012-10-30T06:10:52Z-
dc.date.issued1985en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 6, p. S47-S52en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170789-
dc.description.abstractIn the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine, potassium chloride and partial α-adrenergic activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, end-products of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshArachidonic Aciden_US
dc.subject.meshArachidonic Acids - Metabolismen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshCatechols - Pharmacologyen_US
dc.subject.meshCyclooxygenase Inhibitorsen_US
dc.subject.meshDogsen_US
dc.subject.meshEpinephrine - Pharmacologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshLipoxygenase Inhibitorsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNordihydroguaiaretic Aciden_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.titleLipoxygenase and calcium entry in vascular smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198500076-00009-
dc.identifier.pmid2414595-
dc.identifier.scopuseid_2-s2.0-0022219720en_US
dc.identifier.volume7en_US
dc.identifier.issueSUPPL. 6en_US
dc.identifier.spageS47en_US
dc.identifier.epageS52en_US
dc.identifier.isiWOS:A1985ANY3200009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridRimele, TJ=7004614618en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US

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