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Article: Calcium-entry blockers, vascular smooth muscle and systemic hypertension

TitleCalcium-entry blockers, vascular smooth muscle and systemic hypertension
Authors
Issue Date1985
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 1985, v. 55 n. 3, p. 17B-23B How to Cite?
AbstractAbnormal narrowing of the arterioles, caused by contraction of arteriolar smooth muscle, contributes to the genesis and the maintenance of the increased peripheral resistance observed in hypertension. Activation of the contractile process in vascular smooth muscle requires an increase in cytoplasmic calcium. In most blood vessels, the activator ion enters the cell through specific membrane channels, which can be inhibited by a chemically heterogeneous group of drugs, the calcium-entry blockers. The antihypertensive effect of these agents is probably explained by their inhibitory effect on (1) α-adrenergic activation (the pharmacologic subtype of postjunctional α-adrenoceptor does not necessarily determine the importance of calcium entry); (2) activation by nonadrenergic neurohumoral mediators (for example, serotonin); (3) acceleration of calcium entry by metabolites of arachidonic acid formed by lipoxygenase; and (4) inherent myogenic tone.
Persistent Identifierhttp://hdl.handle.net/10722/170781
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:49Z-
dc.date.available2012-10-30T06:10:49Z-
dc.date.issued1985en_US
dc.identifier.citationAmerican Journal Of Cardiology, 1985, v. 55 n. 3, p. 17B-23Ben_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/170781-
dc.description.abstractAbnormal narrowing of the arterioles, caused by contraction of arteriolar smooth muscle, contributes to the genesis and the maintenance of the increased peripheral resistance observed in hypertension. Activation of the contractile process in vascular smooth muscle requires an increase in cytoplasmic calcium. In most blood vessels, the activator ion enters the cell through specific membrane channels, which can be inhibited by a chemically heterogeneous group of drugs, the calcium-entry blockers. The antihypertensive effect of these agents is probably explained by their inhibitory effect on (1) α-adrenergic activation (the pharmacologic subtype of postjunctional α-adrenoceptor does not necessarily determine the importance of calcium entry); (2) activation by nonadrenergic neurohumoral mediators (for example, serotonin); (3) acceleration of calcium entry by metabolites of arachidonic acid formed by lipoxygenase; and (4) inherent myogenic tone.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonic Acids - Metabolismen_US
dc.subject.meshArterioles - Physiopathologyen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshMuscle Tonus - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiopathologyen_US
dc.subject.meshNorepinephrine - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleCalcium-entry blockers, vascular smooth muscle and systemic hypertensionen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0002-9149(85)90609-5-
dc.identifier.pmid3881910-
dc.identifier.scopuseid_2-s2.0-0021988257en_US
dc.identifier.volume55en_US
dc.identifier.issue3en_US
dc.identifier.spage17Ben_US
dc.identifier.epage23Ben_US
dc.identifier.isiWOS:A1985AAT6600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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