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- Publisher Website: 10.1016/0002-9149(85)90609-5
- Scopus: eid_2-s2.0-0021988257
- PMID: 3881910
- WOS: WOS:A1985AAT6600004
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Article: Calcium-entry blockers, vascular smooth muscle and systemic hypertension
Title | Calcium-entry blockers, vascular smooth muscle and systemic hypertension |
---|---|
Authors | |
Issue Date | 1985 |
Publisher | Excerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/ |
Citation | American Journal Of Cardiology, 1985, v. 55 n. 3, p. 17B-23B How to Cite? |
Abstract | Abnormal narrowing of the arterioles, caused by contraction of arteriolar smooth muscle, contributes to the genesis and the maintenance of the increased peripheral resistance observed in hypertension. Activation of the contractile process in vascular smooth muscle requires an increase in cytoplasmic calcium. In most blood vessels, the activator ion enters the cell through specific membrane channels, which can be inhibited by a chemically heterogeneous group of drugs, the calcium-entry blockers. The antihypertensive effect of these agents is probably explained by their inhibitory effect on (1) α-adrenergic activation (the pharmacologic subtype of postjunctional α-adrenoceptor does not necessarily determine the importance of calcium entry); (2) activation by nonadrenergic neurohumoral mediators (for example, serotonin); (3) acceleration of calcium entry by metabolites of arachidonic acid formed by lipoxygenase; and (4) inherent myogenic tone. |
Persistent Identifier | http://hdl.handle.net/10722/170781 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.950 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:49Z | - |
dc.date.available | 2012-10-30T06:10:49Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | American Journal Of Cardiology, 1985, v. 55 n. 3, p. 17B-23B | en_US |
dc.identifier.issn | 0002-9149 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170781 | - |
dc.description.abstract | Abnormal narrowing of the arterioles, caused by contraction of arteriolar smooth muscle, contributes to the genesis and the maintenance of the increased peripheral resistance observed in hypertension. Activation of the contractile process in vascular smooth muscle requires an increase in cytoplasmic calcium. In most blood vessels, the activator ion enters the cell through specific membrane channels, which can be inhibited by a chemically heterogeneous group of drugs, the calcium-entry blockers. The antihypertensive effect of these agents is probably explained by their inhibitory effect on (1) α-adrenergic activation (the pharmacologic subtype of postjunctional α-adrenoceptor does not necessarily determine the importance of calcium entry); (2) activation by nonadrenergic neurohumoral mediators (for example, serotonin); (3) acceleration of calcium entry by metabolites of arachidonic acid formed by lipoxygenase; and (4) inherent myogenic tone. | en_US |
dc.language | eng | en_US |
dc.publisher | Excerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/ | en_US |
dc.relation.ispartof | American Journal of Cardiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arachidonic Acids - Metabolism | en_US |
dc.subject.mesh | Arterioles - Physiopathology | en_US |
dc.subject.mesh | Calcium - Metabolism | en_US |
dc.subject.mesh | Calcium Channel Blockers - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Muscle Tonus - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiopathology | en_US |
dc.subject.mesh | Norepinephrine - Physiology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Vascular Resistance - Drug Effects | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects | en_US |
dc.title | Calcium-entry blockers, vascular smooth muscle and systemic hypertension | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0002-9149(85)90609-5 | - |
dc.identifier.pmid | 3881910 | - |
dc.identifier.scopus | eid_2-s2.0-0021988257 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 17B | en_US |
dc.identifier.epage | 23B | en_US |
dc.identifier.isi | WOS:A1985AAT6600004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9149 | - |