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Article: Adrenergic pharmacology of human and canine peripheral veins

TitleAdrenergic pharmacology of human and canine peripheral veins
Authors
Issue Date1985
Citation
Federation Proceedings, 1985, v. 44 n. 2, p. 337-340 How to Cite?
AbstractA comparison has been made of the factors concerned with the response of canine and human saphenous veins to adrenergic stimulation. Both vessels have prejunctional muscarinic and β-adrenergic receptors. When activated by appropriate agonists these receptors decrease and increase the output, respectively, of norepinephrine from the nerve endings. Both vessels have postjunctional α1 and α2 adrenoceptors and postjunctional β adrenoceptors. Activation of the former two receptors leads to contraction of the smooth muscle, and of the latter to relaxation. There are, however, qualitative differences. In the human veins the responsiveness of the prejunctional β adrenoceptors exceeds that of the postjunctional, whereas the reverse is true in the dog. As a consequence, in the human vein β-adrenergic agonists augment, and in the canine veins they depress, the contractile response to sympathetic nerve stimulation.
Persistent Identifierhttp://hdl.handle.net/10722/170779
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorShepherd, JTen_US
dc.date.accessioned2012-10-30T06:10:48Z-
dc.date.available2012-10-30T06:10:48Z-
dc.date.issued1985en_US
dc.identifier.citationFederation Proceedings, 1985, v. 44 n. 2, p. 337-340en_US
dc.identifier.issn0014-9446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170779-
dc.description.abstractA comparison has been made of the factors concerned with the response of canine and human saphenous veins to adrenergic stimulation. Both vessels have prejunctional muscarinic and β-adrenergic receptors. When activated by appropriate agonists these receptors decrease and increase the output, respectively, of norepinephrine from the nerve endings. Both vessels have postjunctional α1 and α2 adrenoceptors and postjunctional β adrenoceptors. Activation of the former two receptors leads to contraction of the smooth muscle, and of the latter to relaxation. There are, however, qualitative differences. In the human veins the responsiveness of the prejunctional β adrenoceptors exceeds that of the postjunctional, whereas the reverse is true in the dog. As a consequence, in the human vein β-adrenergic agonists augment, and in the canine veins they depress, the contractile response to sympathetic nerve stimulation.en_US
dc.languageengen_US
dc.relation.ispartofFederation Proceedingsen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAdrenergic Beta-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshReceptors, Muscarinic - Drug Effectsen_US
dc.subject.meshSympathetic Nervous System - Drug Effectsen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVeins - Drug Effects - Innervationen_US
dc.titleAdrenergic pharmacology of human and canine peripheral veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2857141-
dc.identifier.scopuseid_2-s2.0-0021961523en_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.spage337en_US
dc.identifier.epage340en_US
dc.identifier.isiWOS:A1985AEP5100012-
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US

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