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Article: Effect of reduced calcium on lysophosphatidylcholine-induced cardiac arrhythmias

TitleEffect of reduced calcium on lysophosphatidylcholine-induced cardiac arrhythmias
Authors
Issue Date1985
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHA
Citation
Pharmacology, 1985, v. 31 n. 1, p. 11-16 How to Cite?
AbstractLysophosphatidylcholine (LPC) had recently been shown to accumulate in the ischemic heart and was demonstrated to be arrhythmogenic in perfused hearts. The present study was designed to examine the effects of calcium and verapamil on LPC-induced arrhythmias. Rat hearts were perfused through the aorta with oxygenated Krebs-Henseleit buffer at 37 °C. The occurrence of ventricular fibrillation was dependent on the LPC concentration and perfusion time. In subsequent experiments, each heart was perfused with a buffer containing 20 μM LPC for 3 min and was followed with a 10 min washout period. Ventricular fibrillation occurred in all 8 control experiments. When the Ca2+ concentration was reduced to half, only 3 out of 8 hearts fibrillated. In the presence of 0.2 mg/l of verapamil, 7 out of 9 hearts fibrillated, and the time to fibrillation was not increased significantly by verapamil. These results suggest that calcium may be important in LPC-induced arrhythmias, and this effect is not significantly attenuated by the Ca2+ antagonist, verapamil.
Persistent Identifierhttp://hdl.handle.net/10722/170763
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 0.645
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_US
dc.contributor.authorLederman, CLen_US
dc.date.accessioned2012-10-30T06:10:45Z-
dc.date.available2012-10-30T06:10:45Z-
dc.date.issued1985en_US
dc.identifier.citationPharmacology, 1985, v. 31 n. 1, p. 11-16en_US
dc.identifier.issn0031-7012en_US
dc.identifier.urihttp://hdl.handle.net/10722/170763-
dc.description.abstractLysophosphatidylcholine (LPC) had recently been shown to accumulate in the ischemic heart and was demonstrated to be arrhythmogenic in perfused hearts. The present study was designed to examine the effects of calcium and verapamil on LPC-induced arrhythmias. Rat hearts were perfused through the aorta with oxygenated Krebs-Henseleit buffer at 37 °C. The occurrence of ventricular fibrillation was dependent on the LPC concentration and perfusion time. In subsequent experiments, each heart was perfused with a buffer containing 20 μM LPC for 3 min and was followed with a 10 min washout period. Ventricular fibrillation occurred in all 8 control experiments. When the Ca2+ concentration was reduced to half, only 3 out of 8 hearts fibrillated. In the presence of 0.2 mg/l of verapamil, 7 out of 9 hearts fibrillated, and the time to fibrillation was not increased significantly by verapamil. These results suggest that calcium may be important in LPC-induced arrhythmias, and this effect is not significantly attenuated by the Ca2+ antagonist, verapamil.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHAen_US
dc.relation.ispartofPharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Chemically Induceden_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCell Membrane Permeability - Drug Effectsen_US
dc.subject.meshLysophosphatidylcholines - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshVentricular Fibrillation - Chemically Induceden_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleEffect of reduced calcium on lysophosphatidylcholine-induced cardiac arrhythmiasen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000138092-
dc.identifier.pmid4023041-
dc.identifier.scopuseid_2-s2.0-0021813568en_US
dc.identifier.volume31en_US
dc.identifier.issue1en_US
dc.identifier.spage11en_US
dc.identifier.epage16en_US
dc.identifier.isiWOS:A1985AKX2600002-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridLederman, CL=6701809777en_US

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