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Article: The influence of verapamil on the gastric effects of stress in rats

TitleThe influence of verapamil on the gastric effects of stress in rats
Authors
Issue Date1985
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1985, v. 112 n. 3, p. 399-404 How to Cite?
AbstractThe influence of verapamil on stress- or bethanechol-induced gastric effects was investigated in rats. Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall contractions evoked by restraint at 4°C for 1 h. Gastric acid secretion, as well as ulceration in both the forestomach and glandular segment, produced by subcutaneously-injected bethanechol (3.2 mg/kg) were also inhibited. It is concluded that decreased amine release from the mast cells, stomach wall relaxation and reduced gastric acid were responsible for the ulcer-antagonising effects of the calcium-entry blocker. The possible antiulcer actions of verapamil are discussed in the light of present knowledge regarding calcium involvement in the various mechanisms thought to contribute to the pathophysiology of stress ulceration in rat stomachs.
Persistent Identifierhttp://hdl.handle.net/10722/170761
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOgle, CWen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorTong, MCen_US
dc.contributor.authorKoo, MWLen_US
dc.date.accessioned2012-10-30T06:10:44Z-
dc.date.available2012-10-30T06:10:44Z-
dc.date.issued1985en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1985, v. 112 n. 3, p. 399-404en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170761-
dc.description.abstractThe influence of verapamil on stress- or bethanechol-induced gastric effects was investigated in rats. Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall contractions evoked by restraint at 4°C for 1 h. Gastric acid secretion, as well as ulceration in both the forestomach and glandular segment, produced by subcutaneously-injected bethanechol (3.2 mg/kg) were also inhibited. It is concluded that decreased amine release from the mast cells, stomach wall relaxation and reduced gastric acid were responsible for the ulcer-antagonising effects of the calcium-entry blocker. The possible antiulcer actions of verapamil are discussed in the light of present knowledge regarding calcium involvement in the various mechanisms thought to contribute to the pathophysiology of stress ulceration in rat stomachs.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBethanechol Compoundsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Mucosa - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMast Cells - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshStomach Ulcer - Etiology - Prevention & Controlen_US
dc.subject.meshStress, Psychological - Complicationsen_US
dc.subject.meshVerapamil - Therapeutic Useen_US
dc.titleThe influence of verapamil on the gastric effects of stress in ratsen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(85)90787-3-
dc.identifier.pmid4040471-
dc.identifier.scopuseid_2-s2.0-0021796978en_US
dc.identifier.volume112en_US
dc.identifier.issue3en_US
dc.identifier.spage399en_US
dc.identifier.epage404en_US
dc.identifier.isiWOS:A1985ANH6500014-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridTong, MC=24455478600en_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US

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