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Article: Effect of temperature on the responsiveness of cutaneous veins to the extract of Ruscus aculeatus

TitleEffect of temperature on the responsiveness of cutaneous veins to the extract of Ruscus aculeatus
Authors
Issue Date1984
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology: Vascular System, 1984, v. 15 n. 5, p. 431-434 How to Cite?
AbstractIn canine cutaneous veins cooling augments and warming depresses the responses to sympathetic nerve stimulation. In these veins the extract of Ruscus aculeatus (Ruscus) causes contractions due to α-adrenergic activation. To determine the effects of temperature on the response to Ruscus, rings of canine saphenous veins were studied at 24°, 37° and 41°C. At 37°C, Ruscus caused an increase in isometric tension which was depressed by prazosin and rauwolscine. Cooling inhibited the response to Ruscus, while warming augmented it. Rauwolscine potentiated, and prazosin reversed the effect of cooling on contractions evoked by Ruscus. Prazosin reduced, and rauwolscine augmented the effect of warming. These experiments demonstrate that temperature affects the venoconstriction induced by Ruscus in an opposite fashion as that to sympathetic nerve activation, presumably because the α1-adrenergic component of the response to Ruscus predominates.
Persistent Identifierhttp://hdl.handle.net/10722/170758
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRubanyi, Gen_US
dc.contributor.authorMarcelon, Gen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:43Z-
dc.date.available2012-10-30T06:10:43Z-
dc.date.issued1984en_US
dc.identifier.citationGeneral Pharmacology: Vascular System, 1984, v. 15 n. 5, p. 431-434en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/170758-
dc.description.abstractIn canine cutaneous veins cooling augments and warming depresses the responses to sympathetic nerve stimulation. In these veins the extract of Ruscus aculeatus (Ruscus) causes contractions due to α-adrenergic activation. To determine the effects of temperature on the response to Ruscus, rings of canine saphenous veins were studied at 24°, 37° and 41°C. At 37°C, Ruscus caused an increase in isometric tension which was depressed by prazosin and rauwolscine. Cooling inhibited the response to Ruscus, while warming augmented it. Rauwolscine potentiated, and prazosin reversed the effect of cooling on contractions evoked by Ruscus. Prazosin reduced, and rauwolscine augmented the effect of warming. These experiments demonstrate that temperature affects the venoconstriction induced by Ruscus in an opposite fashion as that to sympathetic nerve activation, presumably because the α1-adrenergic component of the response to Ruscus predominates.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacology: Vascular Systemen_US
dc.subject.meshAdrenergic Alpha-Antagonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshMuscle, Smooth, Vascular - Innervation - Physiologyen_US
dc.subject.meshPlant Extracts - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effects - Physiologyen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshTemperatureen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titleEffect of temperature on the responsiveness of cutaneous veins to the extract of Ruscus aculeatusen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(84)90045-4-
dc.identifier.pmid6150876-
dc.identifier.scopuseid_2-s2.0-0021752067en_US
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.identifier.spage431en_US
dc.identifier.epage434en_US
dc.identifier.isiWOS:A1984TU46200013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRubanyi, G=7005517991en_US
dc.identifier.scopusauthoridMarcelon, G=6603299586en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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