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Article: Serotonergic receptor subtypes and vascular reactivity

TitleSerotonergic receptor subtypes and vascular reactivity
Authors
Issue Date1984
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1984, v. 6 SUPPL. 4, p. S564-S574 How to Cite?
AbstractTwo distinct binding sites for serotonin have been identified in brain tissue and labeled 5-HT1 and 5-HT2 binding sites. The receptor mediating contractions of several types of vascular smooth muscle (including the canine basilar artery), aggregation of blood platelets, and contractions of tracheal muscle can be defined as a 5-HT2 serotonergic receptor. The prejunctional inhibitory effect of serotonin on adrenergic neurotransmission is mediated by receptors which have the same affinity for agonists as the 5-HT1 binding sites. The other peripheral actions of serotonin, in particular its vasodilator effects and its excitatory effects on gastrointestinal smooth muscle, do not involve 5-HT2 serotonergic receptors.
Persistent Identifierhttp://hdl.handle.net/10722/170749
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorLeysen, JEen_US
dc.contributor.authorDe Clerck, Fen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:41Z-
dc.date.available2012-10-30T06:10:41Z-
dc.date.issued1984en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1984, v. 6 SUPPL. 4, p. S564-S574en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170749-
dc.description.abstractTwo distinct binding sites for serotonin have been identified in brain tissue and labeled 5-HT1 and 5-HT2 binding sites. The receptor mediating contractions of several types of vascular smooth muscle (including the canine basilar artery), aggregation of blood platelets, and contractions of tracheal muscle can be defined as a 5-HT2 serotonergic receptor. The prejunctional inhibitory effect of serotonin on adrenergic neurotransmission is mediated by receptors which have the same affinity for agonists as the 5-HT1 binding sites. The other peripheral actions of serotonin, in particular its vasodilator effects and its excitatory effects on gastrointestinal smooth muscle, do not involve 5-HT2 serotonergic receptors.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasilar Artery - Drug Effectsen_US
dc.subject.meshBlood Vessels - Drug Effectsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshPlatelet Aggregation - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Serotonin - Drug Effectsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleSerotonergic receptor subtypes and vascular reactivityen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198406004-00003-
dc.identifier.pmid6210424-
dc.identifier.scopuseid_2-s2.0-0021683377en_US
dc.identifier.volume6en_US
dc.identifier.issueSUPPL. 4en_US
dc.identifier.spageS564en_US
dc.identifier.epageS574en_US
dc.identifier.isiWOS:A1984ACE9500003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridLeysen, JE=7103176463en_US
dc.identifier.scopusauthoridDe Clerck, F=7004452566en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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