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Article: The effect of warming on adrenergic neurotransmission in canine cutaneous vein

TitleThe effect of warming on adrenergic neurotransmission in canine cutaneous vein
Authors
Issue Date1984
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org
Citation
Circulation Research, 1984, v. 54 n. 5, p. 547-553 How to Cite?
AbstractThe effect of warming on adrenergic neurotransmission was examined in canine cutaneous veins. Isometric tension was recorded from rings of saphenous veins of the dog in organ chambers filled with physiological salt solution. During contractions caused by potassium or prostaglandin F(2α), warming from 37 to 41° C caused an augmentation. During contractions caused by stimulation of the adrenergic nerves, and by exogenous norepinephrine, warming caused a relaxation. The relaxation with warming was not altered by the β-adrenergic antagonists, propranolol, or by inhibitors of extraneuronal and neuronal uptake of norepinephrine. During contractions evoked by the α2-adrenergic agonists, α-methyl norepinephrine and B-HT 920, warming caused a relaxation, whereas during contractions due to the α1-adrenergic agonists, cirazoline, methoxamine, ST 587, and phenylephrine, it caused an augmentation. The relaxation caused by warming during norepinephrine-induced contractions was prevented by the preferential α2-antagonists yohimbine and rauwolscine, but not by the preferential α1-antagonist, prazosin. In strips of saphenous vein incubated with [3H]norepinephrine, warming did not affect the release of labeled transmitter evoked by nerve stimulation. These experiments indicate that warming directly enhances contractility of vascular smooth muscle, while depressing the responsiveness of cutaneous vessels to sympathetic nerve activation by a selective inhibitory effect on postjunctional α2-adrenoceptors. Relaxation with warming is greater during nerve stimulation than during administration of exogenous norepinephrine, which may be due to a predominance of postjunctional, α2-adrenoceptors in the neuromuscular junction.
Persistent Identifierhttp://hdl.handle.net/10722/170738
ISSN
2015 Impact Factor: 11.551
2015 SCImago Journal Rankings: 5.755
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCooke, JPen_US
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:39Z-
dc.date.available2012-10-30T06:10:39Z-
dc.date.issued1984en_US
dc.identifier.citationCirculation Research, 1984, v. 54 n. 5, p. 547-553en_US
dc.identifier.issn0009-7330en_US
dc.identifier.urihttp://hdl.handle.net/10722/170738-
dc.description.abstractThe effect of warming on adrenergic neurotransmission was examined in canine cutaneous veins. Isometric tension was recorded from rings of saphenous veins of the dog in organ chambers filled with physiological salt solution. During contractions caused by potassium or prostaglandin F(2α), warming from 37 to 41° C caused an augmentation. During contractions caused by stimulation of the adrenergic nerves, and by exogenous norepinephrine, warming caused a relaxation. The relaxation with warming was not altered by the β-adrenergic antagonists, propranolol, or by inhibitors of extraneuronal and neuronal uptake of norepinephrine. During contractions evoked by the α2-adrenergic agonists, α-methyl norepinephrine and B-HT 920, warming caused a relaxation, whereas during contractions due to the α1-adrenergic agonists, cirazoline, methoxamine, ST 587, and phenylephrine, it caused an augmentation. The relaxation caused by warming during norepinephrine-induced contractions was prevented by the preferential α2-antagonists yohimbine and rauwolscine, but not by the preferential α1-antagonist, prazosin. In strips of saphenous vein incubated with [3H]norepinephrine, warming did not affect the release of labeled transmitter evoked by nerve stimulation. These experiments indicate that warming directly enhances contractility of vascular smooth muscle, while depressing the responsiveness of cutaneous vessels to sympathetic nerve activation by a selective inhibitory effect on postjunctional α2-adrenoceptors. Relaxation with warming is greater during nerve stimulation than during administration of exogenous norepinephrine, which may be due to a predominance of postjunctional, α2-adrenoceptors in the neuromuscular junction.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.orgen_US
dc.relation.ispartofCirculation Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshHot Temperatureen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle Relaxationen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshSaphenous Vein - Metabolismen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshSympathetic Nervous System - Physiologyen_US
dc.subject.meshSynaptic Transmissionen_US
dc.subject.meshTissue Distributionen_US
dc.titleThe effect of warming on adrenergic neurotransmission in canine cutaneous veinen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6327115-
dc.identifier.scopuseid_2-s2.0-0021253321en_US
dc.identifier.volume54en_US
dc.identifier.issue5en_US
dc.identifier.spage547en_US
dc.identifier.epage553en_US
dc.identifier.isiWOS:A1984ST38600007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCooke, JP=7202378672en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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