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- Scopus: eid_2-s2.0-0021178426
- PMID: 6718355
- WOS: WOS:A1984SR99300004
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Article: Cooling augments platelet-induced contraction of peripheral arteries of the dog
Title | Cooling augments platelet-induced contraction of peripheral arteries of the dog |
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Authors | |
Issue Date | 1984 |
Publisher | Society for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/ |
Citation | Proceedings Of The Society For Experimental Biology And Medicine, 1984, v. 176 n. 2, p. 119-122 How to Cite? |
Abstract | The effect of cooling on platelet-induced contractions was studied. Rings of canine saphenous arteries were suspended for isometric tension recording in organ baths filled with aerated physiological salt solution. Norepinephrine, 5-hydroxytryptamine, and autologous aggregating platelets all caused contractions that were augmented by cooling the bath content from 37 to 24°C. These contractions were inhibited, in a concentration-dependent manner, by the serotonergic antagonist ketanserin. The alpha1-adrenergic antagonist, prazosin, in concentrations causing progressive inhibition of contractions evoked by norepinephrine did not affect the response to either 5-hydroxytryptamine or platelets. Aggregating platelets were found to release 5-hydroxytryptamine in sufficient amounts to account for the observed contractions. Pretreatment of platelets with the cyclo-oxygenase inhibitor meclofenamate reduced the amount of thromboxane liberated by aggregating platelets but did not influence evoked contractions. These observations suggest that aggregating platelets cause contraction of the canine saphenous artery by releasing 5-hydroxytryptamine. They demonstrate that cooling markedly augments contractions of peripheral arterial smooth muscle caused by aggregating platelets. |
Persistent Identifier | http://hdl.handle.net/10722/170731 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lindblad, LE | en_US |
dc.contributor.author | Shepherd, JT | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:37Z | - |
dc.date.available | 2012-10-30T06:10:37Z | - |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | Proceedings Of The Society For Experimental Biology And Medicine, 1984, v. 176 n. 2, p. 119-122 | en_US |
dc.identifier.issn | 0037-9727 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170731 | - |
dc.description.abstract | The effect of cooling on platelet-induced contractions was studied. Rings of canine saphenous arteries were suspended for isometric tension recording in organ baths filled with aerated physiological salt solution. Norepinephrine, 5-hydroxytryptamine, and autologous aggregating platelets all caused contractions that were augmented by cooling the bath content from 37 to 24°C. These contractions were inhibited, in a concentration-dependent manner, by the serotonergic antagonist ketanserin. The alpha1-adrenergic antagonist, prazosin, in concentrations causing progressive inhibition of contractions evoked by norepinephrine did not affect the response to either 5-hydroxytryptamine or platelets. Aggregating platelets were found to release 5-hydroxytryptamine in sufficient amounts to account for the observed contractions. Pretreatment of platelets with the cyclo-oxygenase inhibitor meclofenamate reduced the amount of thromboxane liberated by aggregating platelets but did not influence evoked contractions. These observations suggest that aggregating platelets cause contraction of the canine saphenous artery by releasing 5-hydroxytryptamine. They demonstrate that cooling markedly augments contractions of peripheral arterial smooth muscle caused by aggregating platelets. | en_US |
dc.language | eng | en_US |
dc.publisher | Society for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/ | en_US |
dc.relation.ispartof | Proceedings of the Society for Experimental Biology and Medicine | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Physiology | en_US |
dc.subject.mesh | Cold Temperature | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Norepinephrine - Physiology | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Raynaud Disease - Physiopathology | en_US |
dc.subject.mesh | Serotonin - Physiology | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.title | Cooling augments platelet-induced contraction of peripheral arteries of the dog | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 6718355 | - |
dc.identifier.scopus | eid_2-s2.0-0021178426 | en_US |
dc.identifier.volume | 176 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 119 | en_US |
dc.identifier.epage | 122 | en_US |
dc.identifier.isi | WOS:A1984SR99300004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lindblad, LE=19735934700 | en_US |
dc.identifier.scopusauthorid | Shepherd, JT=7401742522 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0037-9727 | - |