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Article: Role of the endothelium in the function of vascular fibers | Rôle de l'endothélium dans le fonctionnement des fibres vasculaires.

TitleRole of the endothelium in the function of vascular fibers | Rôle de l'endothélium dans le fonctionnement des fibres vasculaires.
Authors
Issue Date1983
Citation
Journal De Pharmacologie, 1983, v. 14 Suppl 3, p. 73-79 How to Cite?
AbstractThe endothelial cells can enzymatically activate (e.g. angiotensin II) or destroy (e.g. bradykinin, norepinephrine, 5-hydroxytryptamine) vasoactive substances present in the blood (fig. 1). They also generate prostacyclin, which in several vascular areas has potent vasodilator properties (fig. 1). In addition, endothelial cells play an obligatory role in the relaxation induced by acetylcholine in isolated arteries (fig. 2). This is also the case for the inhibitory effect of adenosine triphosphate (fig. 3), arachidonic acid, bradykinin, histamine and thrombin. The inhibitory responses generated by the endothelial cells are not all mediated by identical cellular events. Thus, the endothelium-mediated relaxations induced by arachidonic acid are due mainly to the production of prostacyclin, while those induced by acetylcholine, bradykinin and histamine involve a product of lipoxygenase; the mechanism underlying endothelium-mediated responses to adenosine triphosphate and thrombin are unknown (fig. 4). In isolated veins contracted with norepinephrine, thrombin and arachidonic acid cause increases in tension which are abolished by endothelium removal. In several arteries and veins, the absence of endothelium prevents or reduces the occurrence of further contractions caused by anoxia. Thus, the cells of the intima recognize the presence of certain substances in the blood and in turn generate signals which alter the contractile behavior of the smooth muscle cells of the media.
Persistent Identifierhttp://hdl.handle.net/10722/170709
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:32Z-
dc.date.available2012-10-30T06:10:32Z-
dc.date.issued1983en_US
dc.identifier.citationJournal De Pharmacologie, 1983, v. 14 Suppl 3, p. 73-79en_US
dc.identifier.issn0021-793Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170709-
dc.description.abstractThe endothelial cells can enzymatically activate (e.g. angiotensin II) or destroy (e.g. bradykinin, norepinephrine, 5-hydroxytryptamine) vasoactive substances present in the blood (fig. 1). They also generate prostacyclin, which in several vascular areas has potent vasodilator properties (fig. 1). In addition, endothelial cells play an obligatory role in the relaxation induced by acetylcholine in isolated arteries (fig. 2). This is also the case for the inhibitory effect of adenosine triphosphate (fig. 3), arachidonic acid, bradykinin, histamine and thrombin. The inhibitory responses generated by the endothelial cells are not all mediated by identical cellular events. Thus, the endothelium-mediated relaxations induced by arachidonic acid are due mainly to the production of prostacyclin, while those induced by acetylcholine, bradykinin and histamine involve a product of lipoxygenase; the mechanism underlying endothelium-mediated responses to adenosine triphosphate and thrombin are unknown (fig. 4). In isolated veins contracted with norepinephrine, thrombin and arachidonic acid cause increases in tension which are abolished by endothelium removal. In several arteries and veins, the absence of endothelium prevents or reduces the occurrence of further contractions caused by anoxia. Thus, the cells of the intima recognize the presence of certain substances in the blood and in turn generate signals which alter the contractile behavior of the smooth muscle cells of the media.en_US
dc.languageengen_US
dc.relation.ispartofJournal de Pharmacologieen_US
dc.subject.meshAcetylcholine - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiogenic Amines - Physiologyen_US
dc.subject.meshEndothelium - Metabolism - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshVasoconstrictionen_US
dc.subject.meshVasodilationen_US
dc.titleRole of the endothelium in the function of vascular fibers | Rôle de l'endothélium dans le fonctionnement des fibres vasculaires.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6369000-
dc.identifier.scopuseid_2-s2.0-0021009499en_US
dc.identifier.volume14 Suppl 3en_US
dc.identifier.spage73en_US
dc.identifier.epage79en_US
dc.identifier.isiWOS:A1983SK49100004-
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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