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Article: Effect of Ca2+-entry blockade and serotonergic antagonism on contractions of hypoxic isolated canine coronary arteries

TitleEffect of Ca2+-entry blockade and serotonergic antagonism on contractions of hypoxic isolated canine coronary arteries
Authors
Van Nueten, JMVan Beek, JVanhoutte, PM
Issue Date1983
Citation
Archives Internationales De Pharmacodynamie Et De Therapie, 1983, v. 265 n. 1, p. 172-176 How to Cite?
AbstractLidoflazine, flunarizine, and R 51 469 antagonized contractions of isolated canine coronary arteries caused by depolarizing solution or 5-hydroxytryptamine, and the further increase in tension caused by hypoxia during such contractions. The 5-HT2-antagonist ketanserin, but not methysergide, antagonized contractions induced by 5-hydroxytryptamine, but not those by high K+; it reduced further increases in tension caused by hypoxia only during contractions caused by 5-hydroxytryptamine. Augmentation by hypoxia of coronary vasoconstriction appears to be a Ca2+-dependent phenomenon.
Persistent Identifierhttp://hdl.handle.net/10722/170707
ISSN
0003-9780
ISI Accession Number ID
WOS:A1983RM66900021

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorVan Beek, Jen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:32Z-
dc.date.available2012-10-30T06:10:32Z-
dc.date.issued1983en_US
dc.identifier.citationArchives Internationales De Pharmacodynamie Et De Therapie, 1983, v. 265 n. 1, p. 172-176en_US
dc.identifier.issn0003-9780en_US
dc.identifier.urihttp://hdl.handle.net/10722/170707-
dc.description.abstractLidoflazine, flunarizine, and R 51 469 antagonized contractions of isolated canine coronary arteries caused by depolarizing solution or 5-hydroxytryptamine, and the further increase in tension caused by hypoxia during such contractions. The 5-HT2-antagonist ketanserin, but not methysergide, antagonized contractions induced by 5-hydroxytryptamine, but not those by high K+; it reduced further increases in tension caused by hypoxia only during contractions caused by 5-hydroxytryptamine. Augmentation by hypoxia of coronary vasoconstriction appears to be a Ca2+-dependent phenomenon.en_US
dc.languageengen_US
dc.relation.ispartofArchives Internationales de Pharmacodynamie et de Therapieen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshSerotonin Antagonists - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleEffect of Ca2+-entry blockade and serotonergic antagonism on contractions of hypoxic isolated canine coronary arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6651402-
dc.identifier.scopuseid_2-s2.0-0020973791en_US
dc.identifier.volume265en_US
dc.identifier.issue1en_US
dc.identifier.spage172en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:A1983RM66900021-
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridVan Beek, J=7005937094en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0003-9780-

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