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Article: Effect of cold on the blood vessel wall

TitleEffect of cold on the blood vessel wall
Authors
Issue Date1983
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology: Vascular System, 1983, v. 14 n. 1, p. 61-64 How to Cite?
AbstractThe effect of cold has been studied on isolated canine and human blood vessels. These have led to the following conclusions concerning the phenomenon of the hunting reaction seen in human extremities on their exposure to severe cold. On exposure to cold there is a marked increase in the affinity of the postjunctional α-adrenoceptors for norepinephrine. This results in a powerful constriction of the blood vessels and a cessation of blood flow to the distal tissue. As the temperature of the tissues rapidly falls, sympathetic nerve conduction is interrupted and vasodilatation occurs, due to the cessation of norepinephrine release and the depressor action of cold on the contractile machinery. The resultant return of blood flow rewarms the tissue, nerve conduction is reestablished, and this combined with the increased affinity of the α-adrenoceptors for norepinephrine leads to renewed vasoconstriction. Repetition of this cycle could result in the hunting reaction. There appears to be a difference between the cutaneous artery and vein, in that the latter remains constricted at lower temperatures. Preliminary experiments suggest that the response of the human cutaneous vein to cold is qualitatively similar to the dog vein, although some quantitative differences are present.
Persistent Identifierhttp://hdl.handle.net/10722/170705
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShepherd, JTen_US
dc.contributor.authorRusch, NJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:32Z-
dc.date.available2012-10-30T06:10:32Z-
dc.date.issued1983en_US
dc.identifier.citationGeneral Pharmacology: Vascular System, 1983, v. 14 n. 1, p. 61-64en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/170705-
dc.description.abstractThe effect of cold has been studied on isolated canine and human blood vessels. These have led to the following conclusions concerning the phenomenon of the hunting reaction seen in human extremities on their exposure to severe cold. On exposure to cold there is a marked increase in the affinity of the postjunctional α-adrenoceptors for norepinephrine. This results in a powerful constriction of the blood vessels and a cessation of blood flow to the distal tissue. As the temperature of the tissues rapidly falls, sympathetic nerve conduction is interrupted and vasodilatation occurs, due to the cessation of norepinephrine release and the depressor action of cold on the contractile machinery. The resultant return of blood flow rewarms the tissue, nerve conduction is reestablished, and this combined with the increased affinity of the α-adrenoceptors for norepinephrine leads to renewed vasoconstriction. Repetition of this cycle could result in the hunting reaction. There appears to be a difference between the cutaneous artery and vein, in that the latter remains constricted at lower temperatures. Preliminary experiments suggest that the response of the human cutaneous vein to cold is qualitatively similar to the dog vein, although some quantitative differences are present.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacology: Vascular Systemen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Physiologyen_US
dc.subject.meshBlood Vessels - Innervation - Physiologyen_US
dc.subject.meshCattleen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNeurotransmitter Agents - Metabolismen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Physiologyen_US
dc.subject.meshSympathetic Nervous System - Metabolismen_US
dc.subject.meshVeins - Physiologyen_US
dc.titleEffect of cold on the blood vessel wallen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(83)90064-2-
dc.identifier.pmid6131011-
dc.identifier.scopuseid_2-s2.0-0020698299en_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.identifier.spage61en_US
dc.identifier.epage64en_US
dc.identifier.isiWOS:A1983PY16300013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US
dc.identifier.scopusauthoridRusch, NJ=7005728816en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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