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Article: Muscarinic and β-adrenergic prejunctional modulation of adrenergic neurotransmission in the blood vessel wall

TitleMuscarinic and β-adrenergic prejunctional modulation of adrenergic neurotransmission in the blood vessel wall
Authors
Issue Date1983
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology: Vascular System, 1983, v. 14 n. 1, p. 35-37 How to Cite?
AbstractMany prejunctional inhibitory and excitatory receptors have been described on adrenergic nerve endings in animal arteries and veins, and studies to date have identified some of these in human blood vessels. The latter include muscarinic receptors in cutaneous veins which when activated by acetylcholine inhibit the evoked release of norepinephrine, and β-adrenoceptors which when stimulated by isoproterenol or epinephrine facilitate it. Animal studies suggest that cholinergic vasodilatation can result from prejunctional inhibition of adrenergic neurotransmission. The human saphenous vein appears to contain more prejunctional β-adrenoceptors than the canine, with a consequential greater enhancement of norepinephrine release when these receptors are activated.
Persistent Identifierhttp://hdl.handle.net/10722/170703
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorShepherd, JTen_US
dc.date.accessioned2012-10-30T06:10:31Z-
dc.date.available2012-10-30T06:10:31Z-
dc.date.issued1983en_US
dc.identifier.citationGeneral Pharmacology: Vascular System, 1983, v. 14 n. 1, p. 35-37en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/170703-
dc.description.abstractMany prejunctional inhibitory and excitatory receptors have been described on adrenergic nerve endings in animal arteries and veins, and studies to date have identified some of these in human blood vessels. The latter include muscarinic receptors in cutaneous veins which when activated by acetylcholine inhibit the evoked release of norepinephrine, and β-adrenoceptors which when stimulated by isoproterenol or epinephrine facilitate it. Animal studies suggest that cholinergic vasodilatation can result from prejunctional inhibition of adrenergic neurotransmission. The human saphenous vein appears to contain more prejunctional β-adrenoceptors than the canine, with a consequential greater enhancement of norepinephrine release when these receptors are activated.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacology: Vascular Systemen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropine - Pharmacologyen_US
dc.subject.meshBlood Vessels - Innervationen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHumansen_US
dc.subject.meshReceptors, Adrenergic - Physiologyen_US
dc.subject.meshReceptors, Adrenergic, Beta - Physiologyen_US
dc.subject.meshReceptors, Cholinergic - Physiologyen_US
dc.subject.meshReceptors, Muscarinic - Physiologyen_US
dc.subject.meshSympathetic Nervous System - Physiologyen_US
dc.subject.meshSynaptic Transmissionen_US
dc.titleMuscarinic and β-adrenergic prejunctional modulation of adrenergic neurotransmission in the blood vessel wallen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(83)90059-9-
dc.identifier.pmid6298057-
dc.identifier.scopuseid_2-s2.0-0020682153en_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.identifier.spage35en_US
dc.identifier.epage37en_US
dc.identifier.isiWOS:A1983PY16300008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US

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