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Article: Na+-K+ exchanges in canine arterial and venous smooth muscle.

TitleNa+-K+ exchanges in canine arterial and venous smooth muscle.
Authors
Issue Date1982
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1982, v. 243 n. 4, p. H551-559 How to Cite?
AbstractThe effect of altering active sodium transport was compared in the denervated canine femoral artery and saphenous vein, which respond differently to a variety of humoral and physical stimuli. Potassium removal and ouabain caused contractions that were larger in the vein than in the artery. Activation of sodium transport, by exposing sodium-loaded preparations to potassium, caused transient ouabain-sensitive relaxations in both blood vessels; depending on the contractile agonist used, this relaxant effect was comparable (BaCl2) in both preparations or was larger (norepinephrine) in the artery than in the vein. In both the artery and the vein, potassium-induced relaxations were larger during contractions evoked by BaCl2 than those caused by norepinephrine. In the vein, contractions caused by acetylcholine were inhibited by potassium to the same extent as those caused by BaCl2. These results 1) are compatible with a contribution of sodium transport mechanism to the control of cell membrane permeability for extracellular calcium in vascular smooth muscle; 2) suggest that active sodium-calcium exchanges are functionally more important in venous than in arterial smooth muscle; and 3) illustrate that the heterogeneous behavior of vascular smooth muscle of different anatomic origins reflects differences in excitation-contraction coupling.
Persistent Identifierhttp://hdl.handle.net/10722/170680
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDe Mey, JGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:25Z-
dc.date.available2012-10-30T06:10:25Z-
dc.date.issued1982en_US
dc.identifier.citationThe American Journal Of Physiology, 1982, v. 243 n. 4, p. H551-559en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170680-
dc.description.abstractThe effect of altering active sodium transport was compared in the denervated canine femoral artery and saphenous vein, which respond differently to a variety of humoral and physical stimuli. Potassium removal and ouabain caused contractions that were larger in the vein than in the artery. Activation of sodium transport, by exposing sodium-loaded preparations to potassium, caused transient ouabain-sensitive relaxations in both blood vessels; depending on the contractile agonist used, this relaxant effect was comparable (BaCl2) in both preparations or was larger (norepinephrine) in the artery than in the vein. In both the artery and the vein, potassium-induced relaxations were larger during contractions evoked by BaCl2 than those caused by norepinephrine. In the vein, contractions caused by acetylcholine were inhibited by potassium to the same extent as those caused by BaCl2. These results 1) are compatible with a contribution of sodium transport mechanism to the control of cell membrane permeability for extracellular calcium in vascular smooth muscle; 2) suggest that active sodium-calcium exchanges are functionally more important in venous than in arterial smooth muscle; and 3) illustrate that the heterogeneous behavior of vascular smooth muscle of different anatomic origins reflects differences in excitation-contraction coupling.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Transport, Activeen_US
dc.subject.meshDogsen_US
dc.subject.meshFemoral Artery - Metabolismen_US
dc.subject.meshHydroxydopamines - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Metabolismen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshOuabain - Pharmacologyen_US
dc.subject.meshOxidopamineen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshPotassium - Metabolismen_US
dc.subject.meshSaphenous Vein - Metabolismen_US
dc.subject.meshSodium - Metabolismen_US
dc.titleNa+-K+ exchanges in canine arterial and venous smooth muscle.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6812438-
dc.identifier.scopuseid_2-s2.0-0020201849en_US
dc.identifier.volume243en_US
dc.identifier.issue4en_US
dc.identifier.spageH551en_US
dc.identifier.epage559en_US
dc.identifier.isiWOS:A1982PL49400034-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDe Mey, JG=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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