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Article: Calcium-entry blockers and vascular smooth muscle

TitleCalcium-entry blockers and vascular smooth muscle
Authors
Issue Date1982
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 1982, v. 65 n. 1 II, p. I-11-I-19 How to Cite?
AbstractCalcium-entry blockers depress the myogenic activity and the responsiveness to vasoconstrictor stimuli of the smooth muscle cells of the precapillary vessels. Thus, they can reduce the afterload of the heart and have antihypertensive properties. Their inhibitory effect on the contractile responses of the vascular smooth muscle cells of large arteries also results in the reduction or the abolition of vasospastic episodes. By inhibiting the constrictor responses of the splanchnic capacitance vessels to the sympathetic nervous outflow, they reduce the preload of the heart. However, different calcium-entry blockers differ in their ability to affect different cardiovascular variables and in the onset and duration of their effect; they also have different degrees of tissue selectivity. This variability must reflect differences in pharmacodynamic and pharmacokinetic properties.
Persistent Identifierhttp://hdl.handle.net/10722/170673
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:22Z-
dc.date.available2012-10-30T06:10:22Z-
dc.date.issued1982en_US
dc.identifier.citationCirculation, 1982, v. 65 n. 1 II, p. I-11-I-19en_US
dc.identifier.issn0009-7322en_US
dc.identifier.urihttp://hdl.handle.net/10722/170673-
dc.description.abstractCalcium-entry blockers depress the myogenic activity and the responsiveness to vasoconstrictor stimuli of the smooth muscle cells of the precapillary vessels. Thus, they can reduce the afterload of the heart and have antihypertensive properties. Their inhibitory effect on the contractile responses of the vascular smooth muscle cells of large arteries also results in the reduction or the abolition of vasospastic episodes. By inhibiting the constrictor responses of the splanchnic capacitance vessels to the sympathetic nervous outflow, they reduce the preload of the heart. However, different calcium-entry blockers differ in their ability to affect different cardiovascular variables and in the onset and duration of their effect; they also have different degrees of tissue selectivity. This variability must reflect differences in pharmacodynamic and pharmacokinetic properties.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_US
dc.relation.ispartofCirculationen_US
dc.subject.meshAngina Pectoris - Physiopathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacology - Therapeutic Useen_US
dc.subject.meshCatecholamines - Physiologyen_US
dc.subject.meshHeart Failure - Drug Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshNorepinephrine - Physiologyen_US
dc.subject.meshPotassium - Physiologyen_US
dc.titleCalcium-entry blockers and vascular smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanHoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanHoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7030518-
dc.identifier.scopuseid_2-s2.0-0020042444en_US
dc.identifier.volume65en_US
dc.identifier.issue1 IIen_US
dc.identifier.spageIen_US
dc.identifier.epage11en_US
dc.identifier.isiWOS:A1982MW84300003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanHoutte, PM=7202304247en_US

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