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Article: Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium

TitleHeterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium
Authors
Issue Date1982
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org
Citation
Circulation Research, 1982, v. 51 n. 4, p. 439-447 How to Cite?
AbstractExperiments were designed to determine the contribution of endothelial cells to the heterogeneous behavior of the arterial and venous wall. Rings of canine femoral, pulmonary, saphenous, and splenic arteries and veins, with and without endothelium, were mounted for isometric tension recording in Krebs-Ringer bicarbonate solution. Endothelium-dependent inhibitory responses to acetylcholine, adenosine triphosphate, bovine thrombin, and arachidonic acid were prominent in the arteries. In the veins, only transient endothelium-dependent relaxations to these substances were observed. Removal of the endothelium decreased the augmentation of the response to norepinephrine caused by anoxia in both arteries and veins. In the veins, arachidonic acid and thrombin caused endothelium-dependent increases in tension during contractions evoked by norepinephrine. The endothelium-independent inhibitory effects of isoproterenol and adenosine and the excitatory effects of acetylcholine and ATP were more pronounced in the veins than in the arteries. These experiments demonstrate that in the arterial and venous wall the endothelial cells can contribute to both inhibitory and excitatory responses of the smooth muscle cells of the media. Inhibitory endothelial responses prevail in the arteries, and excitatory ones in the veins.
Persistent Identifierhttp://hdl.handle.net/10722/170669
ISSN
2015 Impact Factor: 11.551
2015 SCImago Journal Rankings: 5.755
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDe Mey, JGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:20Z-
dc.date.available2012-10-30T06:10:20Z-
dc.date.issued1982en_US
dc.identifier.citationCirculation Research, 1982, v. 51 n. 4, p. 439-447en_US
dc.identifier.issn0009-7330en_US
dc.identifier.urihttp://hdl.handle.net/10722/170669-
dc.description.abstractExperiments were designed to determine the contribution of endothelial cells to the heterogeneous behavior of the arterial and venous wall. Rings of canine femoral, pulmonary, saphenous, and splenic arteries and veins, with and without endothelium, were mounted for isometric tension recording in Krebs-Ringer bicarbonate solution. Endothelium-dependent inhibitory responses to acetylcholine, adenosine triphosphate, bovine thrombin, and arachidonic acid were prominent in the arteries. In the veins, only transient endothelium-dependent relaxations to these substances were observed. Removal of the endothelium decreased the augmentation of the response to norepinephrine caused by anoxia in both arteries and veins. In the veins, arachidonic acid and thrombin caused endothelium-dependent increases in tension during contractions evoked by norepinephrine. The endothelium-independent inhibitory effects of isoproterenol and adenosine and the excitatory effects of acetylcholine and ATP were more pronounced in the veins than in the arteries. These experiments demonstrate that in the arterial and venous wall the endothelial cells can contribute to both inhibitory and excitatory responses of the smooth muscle cells of the media. Inhibitory endothelial responses prevail in the arteries, and excitatory ones in the veins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.orgen_US
dc.relation.ispartofCirculation Researchen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAdenosine - Pharmacologyen_US
dc.subject.meshAdenosine Triphosphate - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshArachidonic Acids - Pharmacologyen_US
dc.subject.meshArteries - Drug Effects - Pathology - Physiologyen_US
dc.subject.meshCattleen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshEndothelium - Drug Effects - Pathology - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Pathology - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshThrombin - Pharmacologyen_US
dc.subject.meshVeins - Drug Effects - Pathology - Physiologyen_US
dc.titleHeterogeneous behavior of the canine arterial and venous wall. Importance of the endotheliumen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7127680-
dc.identifier.scopuseid_2-s2.0-0019996073en_US
dc.identifier.volume51en_US
dc.identifier.issue4en_US
dc.identifier.spage439en_US
dc.identifier.epage447en_US
dc.identifier.isiWOS:A1982PN28900004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDe Mey, JG=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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