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Article: Effect of moderate cooling on adrenergic neuroeffector interaction in canine cutaneous veins

TitleEffect of moderate cooling on adrenergic neuroeffector interaction in canine cutaneous veins
Authors
Issue Date1981
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
Blood Vessels, 1981, v. 18 n. 6, p. 281-295 How to Cite?
AbstractExperiments were performed to investigate the effect of moderate cooling on adrenergic neuroeffector interaction in canine cutaneous veins. Helical strips of dog's saphenous vein, untreated or first incubated with 3H-norepinephrine were mounted for superfusion and isometric tension recording; the overflow of endogenous catecholamines or 3H-norepinephrine and its metabolites, respectively, were measured in the superfusate. In other experiments the monoamine oxidase activity or the catechol-O-methyltransferase (COMT) activity of the saphenous vein wall was determined. Moderate cooling (from 37 to 24°C) decreased the evoked release of endogenous norepinephrine during electrical stimulation of the adrenergic nerve endings in the blood vessel wall. Moderate cooling depressed the overflow of 3H-norepinephrine and its metabolites in unstimulated preparations, during electrical stimulation during superfusion with high K+ solution and during exposure to tyramine. Moderate cooling reduced the activity of monoamine oxidase significantly more than that of COMT. The relative alterations in overflow of norepinephrine and its metabolites caused by a same degree of cooling in basal conditions and during the different forms of increased overflow of adrenergic transmitter suggest that lowering the temperature inhibits the exocytotic process, but at the same time slows down the diffusion of norepinephrine from the junctional cleft to the extracellular space to the extent that during sympathetic nerve stimulation at 24°C the effective junctional concentration of the transmitter may be comparable to that obtained at 37°C. The inhibitory effect of moderate cooling on the extraneuronal metabolism of norepinephrine appears to affect little the effective junctional concentration of the adrenergic transmitter.
Persistent Identifierhttp://hdl.handle.net/10722/170660
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJanssens, WJen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:19Z-
dc.date.available2012-10-30T06:10:19Z-
dc.date.issued1981en_US
dc.identifier.citationBlood Vessels, 1981, v. 18 n. 6, p. 281-295en_US
dc.identifier.issn0303-6847en_US
dc.identifier.urihttp://hdl.handle.net/10722/170660-
dc.description.abstractExperiments were performed to investigate the effect of moderate cooling on adrenergic neuroeffector interaction in canine cutaneous veins. Helical strips of dog's saphenous vein, untreated or first incubated with 3H-norepinephrine were mounted for superfusion and isometric tension recording; the overflow of endogenous catecholamines or 3H-norepinephrine and its metabolites, respectively, were measured in the superfusate. In other experiments the monoamine oxidase activity or the catechol-O-methyltransferase (COMT) activity of the saphenous vein wall was determined. Moderate cooling (from 37 to 24°C) decreased the evoked release of endogenous norepinephrine during electrical stimulation of the adrenergic nerve endings in the blood vessel wall. Moderate cooling depressed the overflow of 3H-norepinephrine and its metabolites in unstimulated preparations, during electrical stimulation during superfusion with high K+ solution and during exposure to tyramine. Moderate cooling reduced the activity of monoamine oxidase significantly more than that of COMT. The relative alterations in overflow of norepinephrine and its metabolites caused by a same degree of cooling in basal conditions and during the different forms of increased overflow of adrenergic transmitter suggest that lowering the temperature inhibits the exocytotic process, but at the same time slows down the diffusion of norepinephrine from the junctional cleft to the extracellular space to the extent that during sympathetic nerve stimulation at 24°C the effective junctional concentration of the transmitter may be comparable to that obtained at 37°C. The inhibitory effect of moderate cooling on the extraneuronal metabolism of norepinephrine appears to affect little the effective junctional concentration of the adrenergic transmitter.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVRen_US
dc.relation.ispartofBlood Vesselsen_US
dc.subject.meshAdrenergic Fibers - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatechol O-Methyltransferase - Metabolismen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMandelic Acids - Metabolismen_US
dc.subject.meshMethoxyhydroxyphenylglycol - Metabolismen_US
dc.subject.meshMonoamine Oxidase - Metabolismen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshNeuroeffector Junction - Physiologyen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshNormetanephrine - Metabolismen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Innervation - Physiologyen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshTemperatureen_US
dc.subject.meshTyramine - Pharmacologyen_US
dc.titleEffect of moderate cooling on adrenergic neuroeffector interaction in canine cutaneous veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7326437-
dc.identifier.scopuseid_2-s2.0-0019841667en_US
dc.identifier.volume18en_US
dc.identifier.issue6en_US
dc.identifier.spage281en_US
dc.identifier.epage295en_US
dc.identifier.isiWOS:A1981NB81200005-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridJanssens, WJ=7006876881en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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