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Article: Calcium entry blockers and cardiovascular failure

TitleCalcium entry blockers and cardiovascular failure
Authors
Issue Date1981
Citation
Federation Proceedings, 1981, v. 40 n. 14, p. 2882-2887 How to Cite?
AbstractThe beneficial influence of calcium entry blockers in the treatment of ischemia, both in the heart and in other tissues, can be explained by many effects including 1) relaxation of venous smooth muscle cells, in particular those of the splanchnic veins; 2) a negative inotropic effect on the myocardial cells; 3) negative chronotropic effects on the heart; 4) inhibition of vasospastic episodes in coronary and other large arteries; 5) depression of myogenic activity and responsiveness to vasoconstrictor stimuli in precapillary resistance vessels; 6) inhibition of platelet aggregation; 7) possibly, increases in the deformability of hypoxic red blood cells; 8) protection of endothelial integrity and function; and 9) protection of body cells, in particular myocardial cells, from prolonged exposure to anoxia and from massive entry of Ca2+ during reperfusion. In the case of angina pectoris, the effects on the myocardial cell itself, the decrease in preload and afterload, and the improvement of coronary perfusion combine to allow the patient to perform more work before imbalance is reached between the demands of the myocardial cells and their metabolic supply; the increased work performance favors collateral circulation and withdraws part of the reflex load on the heart that originates from the ischemic myocardium. The calcium entry blockers available vary in their potency to affect the different components of the cardiovascular system.
Persistent Identifierhttp://hdl.handle.net/10722/170651
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:18Z-
dc.date.available2012-10-30T06:10:18Z-
dc.date.issued1981en_US
dc.identifier.citationFederation Proceedings, 1981, v. 40 n. 14, p. 2882-2887en_US
dc.identifier.issn0014-9446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170651-
dc.description.abstractThe beneficial influence of calcium entry blockers in the treatment of ischemia, both in the heart and in other tissues, can be explained by many effects including 1) relaxation of venous smooth muscle cells, in particular those of the splanchnic veins; 2) a negative inotropic effect on the myocardial cells; 3) negative chronotropic effects on the heart; 4) inhibition of vasospastic episodes in coronary and other large arteries; 5) depression of myogenic activity and responsiveness to vasoconstrictor stimuli in precapillary resistance vessels; 6) inhibition of platelet aggregation; 7) possibly, increases in the deformability of hypoxic red blood cells; 8) protection of endothelial integrity and function; and 9) protection of body cells, in particular myocardial cells, from prolonged exposure to anoxia and from massive entry of Ca2+ during reperfusion. In the case of angina pectoris, the effects on the myocardial cell itself, the decrease in preload and afterload, and the improvement of coronary perfusion combine to allow the patient to perform more work before imbalance is reached between the demands of the myocardial cells and their metabolic supply; the increased work performance favors collateral circulation and withdraws part of the reflex load on the heart that originates from the ischemic myocardium. The calcium entry blockers available vary in their potency to affect the different components of the cardiovascular system.en_US
dc.languageengen_US
dc.relation.ispartofFederation Proceedingsen_US
dc.subject.meshAngina Pectoris - Drug Therapyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacology - Therapeutic Useen_US
dc.subject.meshCoronary Circulation - Drug Effectsen_US
dc.subject.meshCoronary Disease - Drug Therapyen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshHeart Rate - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMyocardial Contraction - Drug Effectsen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.titleCalcium entry blockers and cardiovascular failureen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7308499-
dc.identifier.scopuseid_2-s2.0-0019776485en_US
dc.identifier.volume40en_US
dc.identifier.issue14en_US
dc.identifier.spage2882en_US
dc.identifier.epage2887en_US
dc.identifier.isiWOS:A1981MU92400019-
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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