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Article: Effect of calcitonin, hydrocortisone, and parathyroid hormone on canine bone blood vessels.

TitleEffect of calcitonin, hydrocortisone, and parathyroid hormone on canine bone blood vessels.
Authors
Issue Date1981
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
The American Journal Of Physiology, 1981, v. 241 n. 1, p. H91-94 How to Cite?
AbstractExperiments were designed to determine whether or not calcitonin, parathormone, and glucocorticoids have direct effects on the vascular smooth muscle cells of bone blood vessels. Tibias of mongrel dogs were isolated. The arteria nutriens was cannulated and perfused at constant flow with aerated Krebs-Ringer solution (37 degrees C). The perfusion pressure was continuously recorded. In unstimulated preparations calcitonin caused dose-dependent increases in perfusion pressure, indicating that it causes constriction of bone blood vessels. Parathormone did not affect basal perfusion; it did not significantly alter vasoconstrictions caused by the injection of norepinephrine indicating that the hormone has no direct effect on the vascular smooth muscle of bone blood vessels. Hydrocortisone, at low concentrations, augmented the constrictions caused by exogenous norepinephrine and periarterial nerve stimulation; at higher concentrations, hydrocortisone caused a dose-dependent inhibition of the response to adrenergic activation. The depressant effect of hydrocortisone was antagonized by propranolol, suggesting that the glucocorticoid facilitates beta-adrenergic relaxation of the vascular smooth muscle cells by catecholamines.
Persistent Identifierhttp://hdl.handle.net/10722/170647
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDriessens, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:17Z-
dc.date.available2012-10-30T06:10:17Z-
dc.date.issued1981en_US
dc.identifier.citationThe American Journal Of Physiology, 1981, v. 241 n. 1, p. H91-94en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170647-
dc.description.abstractExperiments were designed to determine whether or not calcitonin, parathormone, and glucocorticoids have direct effects on the vascular smooth muscle cells of bone blood vessels. Tibias of mongrel dogs were isolated. The arteria nutriens was cannulated and perfused at constant flow with aerated Krebs-Ringer solution (37 degrees C). The perfusion pressure was continuously recorded. In unstimulated preparations calcitonin caused dose-dependent increases in perfusion pressure, indicating that it causes constriction of bone blood vessels. Parathormone did not affect basal perfusion; it did not significantly alter vasoconstrictions caused by the injection of norepinephrine indicating that the hormone has no direct effect on the vascular smooth muscle of bone blood vessels. Hydrocortisone, at low concentrations, augmented the constrictions caused by exogenous norepinephrine and periarterial nerve stimulation; at higher concentrations, hydrocortisone caused a dose-dependent inhibition of the response to adrenergic activation. The depressant effect of hydrocortisone was antagonized by propranolol, suggesting that the glucocorticoid facilitates beta-adrenergic relaxation of the vascular smooth muscle cells by catecholamines.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofThe American journal of physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone And Bones - Blood Supply - Innervationen_US
dc.subject.meshCalcitonin - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshHydrocortisone - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshParathyroid Hormone - Pharmacologyen_US
dc.subject.meshPropranolol - Pharmacologyen_US
dc.subject.meshSalmonen_US
dc.subject.meshSwineen_US
dc.titleEffect of calcitonin, hydrocortisone, and parathyroid hormone on canine bone blood vessels.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7246794en_US
dc.identifier.scopuseid_2-s2.0-0019595524en_US
dc.identifier.volume241en_US
dc.identifier.issue1en_US
dc.identifier.spageH91en_US
dc.identifier.epage94en_US
dc.identifier.isiWOS:A1981LY93800051-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDriessens, M=7004361873en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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