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- Publisher Website: 10.1161/01.RES.48.6.875
- Scopus: eid_2-s2.0-0019506297
- PMID: 6261986
- WOS: WOS:A1981LR83900013
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Article: Uneven distribution of postjunctional alpha1- and alpha2-like adrenoceptors in canine arterial and venous smooth muscle
Title | Uneven distribution of postjunctional alpha1- and alpha2-like adrenoceptors in canine arterial and venous smooth muscle |
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Authors | |
Issue Date | 1981 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org |
Citation | Circulation Research, 1981, v. 48 n. 6, p. 875-883 How to Cite? |
Abstract | We studied isolated canine arteries and veins to compare the pharmacological properties of their postjunctional alpha-adrenoceptors. Rings of femoral and splenic arteries and of femoral and saphenous veins were mounted for isometric tension recording in organ chambers filled with Krebs-Ringer bicarbonate solution. The four blood vessels contracted when exposed to methoxamine, norepinephrine, phenylephrine, and tramazoline; clonidine failed to induce contraction only in the splenic artery. The relative sensitivity to methoxamine was comparable in the arteries and veins, but that for phenylephrine was larger in the former. The veins, but not the arteries, were more sensitive to clonidine and tramazoline than to phenylephrine or methoxamine. Phentolamine was a competitive antagonist against norepinephrine in the arteries and the veins. Prazosin was a competitive antagonist only in the arteries. The competitive antagonistic properties of yohimbine were more pronounced in the veins than in the arteries. Verapamil depressed to the same extent the contractile responses of saphenous veins to clonidine and norepinephrine, but reduced the contractions caused by methoxamine more than those due to norepinephrine. These results indicate the presence of both alpha1- and alpha2-like adrenoceptors on venous smooth muscle cells, whereas arterial smooth muscle cells contain mainly postjunctional alpha1-adrenoceptors. |
Persistent Identifier | http://hdl.handle.net/10722/170646 |
ISSN | 2023 Impact Factor: 16.5 2023 SCImago Journal Rankings: 4.903 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | De Mey, J | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:17Z | - |
dc.date.available | 2012-10-30T06:10:17Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Circulation Research, 1981, v. 48 n. 6, p. 875-883 | en_US |
dc.identifier.issn | 0009-7330 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170646 | - |
dc.description.abstract | We studied isolated canine arteries and veins to compare the pharmacological properties of their postjunctional alpha-adrenoceptors. Rings of femoral and splenic arteries and of femoral and saphenous veins were mounted for isometric tension recording in organ chambers filled with Krebs-Ringer bicarbonate solution. The four blood vessels contracted when exposed to methoxamine, norepinephrine, phenylephrine, and tramazoline; clonidine failed to induce contraction only in the splenic artery. The relative sensitivity to methoxamine was comparable in the arteries and veins, but that for phenylephrine was larger in the former. The veins, but not the arteries, were more sensitive to clonidine and tramazoline than to phenylephrine or methoxamine. Phentolamine was a competitive antagonist against norepinephrine in the arteries and the veins. Prazosin was a competitive antagonist only in the arteries. The competitive antagonistic properties of yohimbine were more pronounced in the veins than in the arteries. Verapamil depressed to the same extent the contractile responses of saphenous veins to clonidine and norepinephrine, but reduced the contractions caused by methoxamine more than those due to norepinephrine. These results indicate the presence of both alpha1- and alpha2-like adrenoceptors on venous smooth muscle cells, whereas arterial smooth muscle cells contain mainly postjunctional alpha1-adrenoceptors. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org | en_US |
dc.relation.ispartof | Circulation Research | en_US |
dc.subject.mesh | 1-Naphthylamine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Clonidine - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Femoral Artery - Drug Effects | en_US |
dc.subject.mesh | Femoral Vein - Drug Effects | en_US |
dc.subject.mesh | Imidazoles - Pharmacology | en_US |
dc.subject.mesh | Methoxamine - Pharmacology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Phenylephrine - Pharmacology | en_US |
dc.subject.mesh | Receptors, Adrenergic | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha | en_US |
dc.subject.mesh | Saphenous Vein - Drug Effects | en_US |
dc.subject.mesh | Splenic Artery - Drug Effects | en_US |
dc.subject.mesh | Verapamil - Pharmacology | en_US |
dc.title | Uneven distribution of postjunctional alpha1- and alpha2-like adrenoceptors in canine arterial and venous smooth muscle | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.RES.48.6.875 | - |
dc.identifier.pmid | 6261986 | - |
dc.identifier.scopus | eid_2-s2.0-0019506297 | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 875 | en_US |
dc.identifier.epage | 883 | en_US |
dc.identifier.isi | WOS:A1981LR83900013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | De Mey, J=7101918486 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7330 | - |