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Article: Uneven distribution of postjunctional alpha1- and alpha2-like adrenoceptors in canine arterial and venous smooth muscle

TitleUneven distribution of postjunctional alpha1- and alpha2-like adrenoceptors in canine arterial and venous smooth muscle
Authors
Issue Date1981
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org
Citation
Circulation Research, 1981, v. 48 n. 6, p. 875-883 How to Cite?
AbstractWe studied isolated canine arteries and veins to compare the pharmacological properties of their postjunctional alpha-adrenoceptors. Rings of femoral and splenic arteries and of femoral and saphenous veins were mounted for isometric tension recording in organ chambers filled with Krebs-Ringer bicarbonate solution. The four blood vessels contracted when exposed to methoxamine, norepinephrine, phenylephrine, and tramazoline; clonidine failed to induce contraction only in the splenic artery. The relative sensitivity to methoxamine was comparable in the arteries and veins, but that for phenylephrine was larger in the former. The veins, but not the arteries, were more sensitive to clonidine and tramazoline than to phenylephrine or methoxamine. Phentolamine was a competitive antagonist against norepinephrine in the arteries and the veins. Prazosin was a competitive antagonist only in the arteries. The competitive antagonistic properties of yohimbine were more pronounced in the veins than in the arteries. Verapamil depressed to the same extent the contractile responses of saphenous veins to clonidine and norepinephrine, but reduced the contractions caused by methoxamine more than those due to norepinephrine. These results indicate the presence of both alpha1- and alpha2-like adrenoceptors on venous smooth muscle cells, whereas arterial smooth muscle cells contain mainly postjunctional alpha1-adrenoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/170646
ISSN
2015 Impact Factor: 11.551
2015 SCImago Journal Rankings: 5.755
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDe Mey, Jen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:17Z-
dc.date.available2012-10-30T06:10:17Z-
dc.date.issued1981en_US
dc.identifier.citationCirculation Research, 1981, v. 48 n. 6, p. 875-883en_US
dc.identifier.issn0009-7330en_US
dc.identifier.urihttp://hdl.handle.net/10722/170646-
dc.description.abstractWe studied isolated canine arteries and veins to compare the pharmacological properties of their postjunctional alpha-adrenoceptors. Rings of femoral and splenic arteries and of femoral and saphenous veins were mounted for isometric tension recording in organ chambers filled with Krebs-Ringer bicarbonate solution. The four blood vessels contracted when exposed to methoxamine, norepinephrine, phenylephrine, and tramazoline; clonidine failed to induce contraction only in the splenic artery. The relative sensitivity to methoxamine was comparable in the arteries and veins, but that for phenylephrine was larger in the former. The veins, but not the arteries, were more sensitive to clonidine and tramazoline than to phenylephrine or methoxamine. Phentolamine was a competitive antagonist against norepinephrine in the arteries and the veins. Prazosin was a competitive antagonist only in the arteries. The competitive antagonistic properties of yohimbine were more pronounced in the veins than in the arteries. Verapamil depressed to the same extent the contractile responses of saphenous veins to clonidine and norepinephrine, but reduced the contractions caused by methoxamine more than those due to norepinephrine. These results indicate the presence of both alpha1- and alpha2-like adrenoceptors on venous smooth muscle cells, whereas arterial smooth muscle cells contain mainly postjunctional alpha1-adrenoceptors.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.orgen_US
dc.relation.ispartofCirculation Researchen_US
dc.subject.mesh1-Naphthylamine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshClonidine - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshFemoral Artery - Drug Effectsen_US
dc.subject.meshFemoral Vein - Drug Effectsen_US
dc.subject.meshImidazoles - Pharmacologyen_US
dc.subject.meshMethoxamine - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergicen_US
dc.subject.meshReceptors, Adrenergic, Alphaen_US
dc.subject.meshSaphenous Vein - Drug Effectsen_US
dc.subject.meshSplenic Artery - Drug Effectsen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleUneven distribution of postjunctional alpha1- and alpha2-like adrenoceptors in canine arterial and venous smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6261986-
dc.identifier.scopuseid_2-s2.0-0019506297en_US
dc.identifier.volume48en_US
dc.identifier.issue6en_US
dc.identifier.spage875en_US
dc.identifier.epage883en_US
dc.identifier.isiWOS:A1981LR83900013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDe Mey, J=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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