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Article: Monovalent ion specificity of the electrogenic sodium pump in vascular smooth muscle

TitleMonovalent ion specificity of the electrogenic sodium pump in vascular smooth muscle
Authors
Issue Date1981
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Proceedings Of The Society For Experimental Biology And Medicine, 1981, v. 166 n. 3, p. 457-461 How to Cite?
AbstractExperiments were performed to determine the monovalent ion specificity of the electrogenic sodium pump in vascular smooth muscle. Helical strips of rat tail artery relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. This relaxation is due to the electrogenic pumping of sodium and potassium which produces membrane hyperpolarization. The magnitude of the relaxation was decreased when the strips were incubated in solutions containing low concentrations of potassium (0.01-5.0 mM) instead of zero potassium. Potassium-induced relaxation was inhibited by ouabain. Helical strips also relaxed in response to rubidium, cesium, and ammonium when these were added instead of potassium to a potassium-free solution. The effectiveness of the monovalent ions in producing relaxation was in the following order: rubidium ≥ potassium > ammonium > cesium. Ouabain inhibited the relaxation responses induced by these latter ions. The results suggest: small changes of the external potassium concentration can modify the amplitude of potassium-induced relaxation, presumably by affecting the intensity of the electrogenic pump; and rubidium, cesium, and ammonium ions can substitute for potassium in producing sodium pump electrogenicity, as evidenced by relaxation after addition of these ions and by inhibition of the relaxation in response to these ions by ouabain.
Persistent Identifierhttp://hdl.handle.net/10722/170639
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWebb, RCen_US
dc.contributor.authorLockette, WEen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorBohr, DFen_US
dc.date.accessioned2012-10-30T06:10:15Z-
dc.date.available2012-10-30T06:10:15Z-
dc.date.issued1981en_US
dc.identifier.citationProceedings Of The Society For Experimental Biology And Medicine, 1981, v. 166 n. 3, p. 457-461en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/170639-
dc.description.abstractExperiments were performed to determine the monovalent ion specificity of the electrogenic sodium pump in vascular smooth muscle. Helical strips of rat tail artery relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. This relaxation is due to the electrogenic pumping of sodium and potassium which produces membrane hyperpolarization. The magnitude of the relaxation was decreased when the strips were incubated in solutions containing low concentrations of potassium (0.01-5.0 mM) instead of zero potassium. Potassium-induced relaxation was inhibited by ouabain. Helical strips also relaxed in response to rubidium, cesium, and ammonium when these were added instead of potassium to a potassium-free solution. The effectiveness of the monovalent ions in producing relaxation was in the following order: rubidium ≥ potassium > ammonium > cesium. Ouabain inhibited the relaxation responses induced by these latter ions. The results suggest: small changes of the external potassium concentration can modify the amplitude of potassium-induced relaxation, presumably by affecting the intensity of the electrogenic pump; and rubidium, cesium, and ammonium ions can substitute for potassium in producing sodium pump electrogenicity, as evidenced by relaxation after addition of these ions and by inhibition of the relaxation in response to these ions by ouabain.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofProceedings of the Society for Experimental Biology and Medicineen_US
dc.subject.meshAmmonia - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Enzymologyen_US
dc.subject.meshCations, Monovalent - Metabolismen_US
dc.subject.meshCesium - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Enzymologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshRubidium - Pharmacologyen_US
dc.subject.meshSodium-Potassium-Exchanging Atpase - Metabolismen_US
dc.subject.meshSubstrate Specificityen_US
dc.titleMonovalent ion specificity of the electrogenic sodium pump in vascular smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6259648-
dc.identifier.scopuseid_2-s2.0-0019450511en_US
dc.identifier.volume166en_US
dc.identifier.issue3en_US
dc.identifier.spage457en_US
dc.identifier.epage461en_US
dc.identifier.isiWOS:A1981LH90000024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWebb, RC=6603072737en_US
dc.identifier.scopusauthoridLockette, WE=7003697162en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridBohr, DF=7004979426en_US

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