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- Publisher Website: 10.1097/00005344-198103000-00002
- Scopus: eid_2-s2.0-0019427902
- PMID: 6166795
- WOS: WOS:A1981LC37500002
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Article: Tachyphylaxis to 5-hydroxytryptamine in perfuse kidneys from spontaneously hypertensive and normotensive rats
Title | Tachyphylaxis to 5-hydroxytryptamine in perfuse kidneys from spontaneously hypertensive and normotensive rats |
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Authors | |
Keywords | 5-Hydroxytryptamine Perfused kidney Spontaneously hypertensive rat Tachyphylaxis |
Issue Date | 1981 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1981, v. 3 n. 2, p. 229-235 How to Cite? |
Abstract | Isolated perfused kidneys from 4- to 6-month-old spontaneously hypertensive rats (SHR, Japanese strain) exhibit increased 'vascular reactivity' to 5-hydroxytryptamine (5-HT) and a slower rate of development of tachyphylaxis to this substance when compared with kidneys from normotensive Wistar-Kyoto (WKY) rats. We investigated the possibility that the reduced rate of development of tachyphylaxis could be related to an interaction of 5-HT with adrenergic mechanisms or with endogenous 5-HT. Tachyphylaxis was induced by repeated administration of 5-HT to kidneys from SHR and WKY rats. This procedure did not affect vasoconstrictor responses evoked by norepinephrine. The development of tachyphylaxis to 5-HT in kidneys from SHR and WKY rats was not changed by chemical sympathectomy with 6-hydroxydopamine. Treatment of SHR with para-chlorophenylalanine did not affect their blood pressure or the development of tachyphylaxis to 5-HT. These results indicate that delayed tachyphylaxis to 5-HT in kidneys of SHR is not due to an interference with adrenergic mechanisms and does not depend on endogenous 5-HT levels. The phenomenon represents an unusual modification of vascular smooth muscle exposed to chronic high pressure, but it is unlikely that the vasoconstrictor effects of 5-HT contribute to the maintenance of hypertension in the SHR. |
Persistent Identifier | http://hdl.handle.net/10722/170631 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Collis, MG | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:13Z | - |
dc.date.available | 2012-10-30T06:10:13Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1981, v. 3 n. 2, p. 229-235 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170631 | - |
dc.description.abstract | Isolated perfused kidneys from 4- to 6-month-old spontaneously hypertensive rats (SHR, Japanese strain) exhibit increased 'vascular reactivity' to 5-hydroxytryptamine (5-HT) and a slower rate of development of tachyphylaxis to this substance when compared with kidneys from normotensive Wistar-Kyoto (WKY) rats. We investigated the possibility that the reduced rate of development of tachyphylaxis could be related to an interaction of 5-HT with adrenergic mechanisms or with endogenous 5-HT. Tachyphylaxis was induced by repeated administration of 5-HT to kidneys from SHR and WKY rats. This procedure did not affect vasoconstrictor responses evoked by norepinephrine. The development of tachyphylaxis to 5-HT in kidneys from SHR and WKY rats was not changed by chemical sympathectomy with 6-hydroxydopamine. Treatment of SHR with para-chlorophenylalanine did not affect their blood pressure or the development of tachyphylaxis to 5-HT. These results indicate that delayed tachyphylaxis to 5-HT in kidneys of SHR is not due to an interference with adrenergic mechanisms and does not depend on endogenous 5-HT levels. The phenomenon represents an unusual modification of vascular smooth muscle exposed to chronic high pressure, but it is unlikely that the vasoconstrictor effects of 5-HT contribute to the maintenance of hypertension in the SHR. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | 5-Hydroxytryptamine | - |
dc.subject | Perfused kidney | - |
dc.subject | Spontaneously hypertensive rat | - |
dc.subject | Tachyphylaxis | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Pressure - Drug Effects | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fenclonine - Pharmacology | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Kidney - Drug Effects | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Perfusion | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Drug Effects | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Sympathetic Nervous System - Drug Effects - Physiopathology | en_US |
dc.subject.mesh | Tachyphylaxis | en_US |
dc.title | Tachyphylaxis to 5-hydroxytryptamine in perfuse kidneys from spontaneously hypertensive and normotensive rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005344-198103000-00002 | - |
dc.identifier.pmid | 6166795 | - |
dc.identifier.scopus | eid_2-s2.0-0019427902 | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 229 | en_US |
dc.identifier.epage | 235 | en_US |
dc.identifier.isi | WOS:A1981LC37500002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Collis, MG=7005797278 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0160-2446 | - |