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Article: Tachyphylaxis to 5-hydroxytryptamine in perfuse kidneys from spontaneously hypertensive and normotensive rats

TitleTachyphylaxis to 5-hydroxytryptamine in perfuse kidneys from spontaneously hypertensive and normotensive rats
Authors
Issue Date1981
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1981, v. 3 n. 2, p. 229-235 How to Cite?
AbstractIsolated perfused kidneys from 4- to 6-month-old spontaneously hypertensive rats (SHR, Japanese strain) exhibit increased 'vascular reactivity' to 5-hydroxytryptamine (5-HT) and a slower rate of development of tachyphylaxis to this substance when compared with kidneys from normotensive Wistar-Kyoto (WKY) rats. We investigated the possibility that the reduced rate of development of tachyphylaxis could be related to an interaction of 5-HT with adrenergic mechanisms or with endogenous 5-HT. Tachyphylaxis was induced by repeated administration of 5-HT to kidneys from SHR and WKY rats. This procedure did not affect vasoconstrictor responses evoked by norepinephrine. The development of tachyphylaxis to 5-HT in kidneys from SHR and WKY rats was not changed by chemical sympathectomy with 6-hydroxydopamine. Treatment of SHR with para-chlorophenylalanine did not affect their blood pressure or the development of tachyphylaxis to 5-HT. These results indicate that delayed tachyphylaxis to 5-HT in kidneys of SHR is not due to an interference with adrenergic mechanisms and does not depend on endogenous 5-HT levels. The phenomenon represents an unusual modification of vascular smooth muscle exposed to chronic high pressure, but it is unlikely that the vasoconstrictor effects of 5-HT contribute to the maintenance of hypertension in the SHR.
Persistent Identifierhttp://hdl.handle.net/10722/170631
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCollis, MGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:13Z-
dc.date.available2012-10-30T06:10:13Z-
dc.date.issued1981en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1981, v. 3 n. 2, p. 229-235en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170631-
dc.description.abstractIsolated perfused kidneys from 4- to 6-month-old spontaneously hypertensive rats (SHR, Japanese strain) exhibit increased 'vascular reactivity' to 5-hydroxytryptamine (5-HT) and a slower rate of development of tachyphylaxis to this substance when compared with kidneys from normotensive Wistar-Kyoto (WKY) rats. We investigated the possibility that the reduced rate of development of tachyphylaxis could be related to an interaction of 5-HT with adrenergic mechanisms or with endogenous 5-HT. Tachyphylaxis was induced by repeated administration of 5-HT to kidneys from SHR and WKY rats. This procedure did not affect vasoconstrictor responses evoked by norepinephrine. The development of tachyphylaxis to 5-HT in kidneys from SHR and WKY rats was not changed by chemical sympathectomy with 6-hydroxydopamine. Treatment of SHR with para-chlorophenylalanine did not affect their blood pressure or the development of tachyphylaxis to 5-HT. These results indicate that delayed tachyphylaxis to 5-HT in kidneys of SHR is not due to an interference with adrenergic mechanisms and does not depend on endogenous 5-HT levels. The phenomenon represents an unusual modification of vascular smooth muscle exposed to chronic high pressure, but it is unlikely that the vasoconstrictor effects of 5-HT contribute to the maintenance of hypertension in the SHR.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshFenclonine - Pharmacologyen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshKidney - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPerfusionen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Drug Effectsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSympathetic Nervous System - Drug Effects - Physiopathologyen_US
dc.subject.meshTachyphylaxisen_US
dc.titleTachyphylaxis to 5-hydroxytryptamine in perfuse kidneys from spontaneously hypertensive and normotensive ratsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198103000-00002-
dc.identifier.pmid6166795-
dc.identifier.scopuseid_2-s2.0-0019427902en_US
dc.identifier.volume3en_US
dc.identifier.issue2en_US
dc.identifier.spage229en_US
dc.identifier.epage235en_US
dc.identifier.isiWOS:A1981LC37500002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCollis, MG=7005797278en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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