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Article: Calcium efflux in rat tail artery during potassium induced relaxation

TitleCalcium efflux in rat tail artery during potassium induced relaxation
Authors
Issue Date1980
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Proceedings Of The Society For Experimental Biology And Medicine, 1980, v. 164 n. 3, p. 252-256 How to Cite?
AbstractThe current study investigates the mechanism by which the concentration of activator Ca 2+ is decreased during potassium induced relaxation of vascular smooth muscle. Helically cut strips of rat tail artery were mounted between a fixed base and force transducers; isometric contractions were recorded. The arterial strips relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. The efflux of 45Ca 2+ from the strips was stimulated by norepinephrine during the potassium-free cycle. This increase in efflux was prevented during potassium induced relaxation. D-600, an inhibitor of transmembrane Ca 2+ flux, reduced the magnitude of potassium induced relaxation by 35%. These observations suggest that relaxation in response to potassium is the result of a decrease in membrane permeability to Ca 2+ coupled with an increase in Ca 2+ sequestration at intracellular sites.
Persistent Identifierhttp://hdl.handle.net/10722/170623
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWebb, RCen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorBohr, DFen_US
dc.date.accessioned2012-10-30T06:10:11Z-
dc.date.available2012-10-30T06:10:11Z-
dc.date.issued1980en_US
dc.identifier.citationProceedings Of The Society For Experimental Biology And Medicine, 1980, v. 164 n. 3, p. 252-256en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/170623-
dc.description.abstractThe current study investigates the mechanism by which the concentration of activator Ca 2+ is decreased during potassium induced relaxation of vascular smooth muscle. Helically cut strips of rat tail artery were mounted between a fixed base and force transducers; isometric contractions were recorded. The arterial strips relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. The efflux of 45Ca 2+ from the strips was stimulated by norepinephrine during the potassium-free cycle. This increase in efflux was prevented during potassium induced relaxation. D-600, an inhibitor of transmembrane Ca 2+ flux, reduced the magnitude of potassium induced relaxation by 35%. These observations suggest that relaxation in response to potassium is the result of a decrease in membrane permeability to Ca 2+ coupled with an increase in Ca 2+ sequestration at intracellular sites.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofProceedings of the Society for Experimental Biology and Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Metabolismen_US
dc.subject.meshBiological Transport - Drug Effectsen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshGallopamil - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Metabolismen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshTailen_US
dc.titleCalcium efflux in rat tail artery during potassium induced relaxationen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7403096-
dc.identifier.scopuseid_2-s2.0-0019312868en_US
dc.identifier.volume164en_US
dc.identifier.issue3en_US
dc.identifier.spage252en_US
dc.identifier.epage256en_US
dc.identifier.isiWOS:A1980KB07300004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWebb, RC=6603072737en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridBohr, DF=7004979426en_US

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