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- Scopus: eid_2-s2.0-0019312868
- PMID: 7403096
- WOS: WOS:A1980KB07300004
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Article: Calcium efflux in rat tail artery during potassium induced relaxation
Title | Calcium efflux in rat tail artery during potassium induced relaxation |
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Authors | |
Issue Date | 1980 |
Publisher | Society for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/ |
Citation | Proceedings Of The Society For Experimental Biology And Medicine, 1980, v. 164 n. 3, p. 252-256 How to Cite? |
Abstract | The current study investigates the mechanism by which the concentration of activator Ca 2+ is decreased during potassium induced relaxation of vascular smooth muscle. Helically cut strips of rat tail artery were mounted between a fixed base and force transducers; isometric contractions were recorded. The arterial strips relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. The efflux of 45Ca 2+ from the strips was stimulated by norepinephrine during the potassium-free cycle. This increase in efflux was prevented during potassium induced relaxation. D-600, an inhibitor of transmembrane Ca 2+ flux, reduced the magnitude of potassium induced relaxation by 35%. These observations suggest that relaxation in response to potassium is the result of a decrease in membrane permeability to Ca 2+ coupled with an increase in Ca 2+ sequestration at intracellular sites. |
Persistent Identifier | http://hdl.handle.net/10722/170623 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Webb, RC | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Bohr, DF | en_US |
dc.date.accessioned | 2012-10-30T06:10:11Z | - |
dc.date.available | 2012-10-30T06:10:11Z | - |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Proceedings Of The Society For Experimental Biology And Medicine, 1980, v. 164 n. 3, p. 252-256 | en_US |
dc.identifier.issn | 0037-9727 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170623 | - |
dc.description.abstract | The current study investigates the mechanism by which the concentration of activator Ca 2+ is decreased during potassium induced relaxation of vascular smooth muscle. Helically cut strips of rat tail artery were mounted between a fixed base and force transducers; isometric contractions were recorded. The arterial strips relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. The efflux of 45Ca 2+ from the strips was stimulated by norepinephrine during the potassium-free cycle. This increase in efflux was prevented during potassium induced relaxation. D-600, an inhibitor of transmembrane Ca 2+ flux, reduced the magnitude of potassium induced relaxation by 35%. These observations suggest that relaxation in response to potassium is the result of a decrease in membrane permeability to Ca 2+ coupled with an increase in Ca 2+ sequestration at intracellular sites. | en_US |
dc.language | eng | en_US |
dc.publisher | Society for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/ | en_US |
dc.relation.ispartof | Proceedings of the Society for Experimental Biology and Medicine | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arteries - Metabolism | en_US |
dc.subject.mesh | Biological Transport - Drug Effects | en_US |
dc.subject.mesh | Calcium - Metabolism | en_US |
dc.subject.mesh | Gallopamil - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth - Metabolism | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Tail | en_US |
dc.title | Calcium efflux in rat tail artery during potassium induced relaxation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 7403096 | - |
dc.identifier.scopus | eid_2-s2.0-0019312868 | en_US |
dc.identifier.volume | 164 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 252 | en_US |
dc.identifier.epage | 256 | en_US |
dc.identifier.isi | WOS:A1980KB07300004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Webb, RC=6603072737 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Bohr, DF=7004979426 | en_US |
dc.identifier.issnl | 0037-9727 | - |